No abstract

Colorectal cancer incidence in the LSS sample during 1950-80 was investigated. A total of 730 incidence cases of colorectal cancer were confirmed from a variety of sources. Sixty-two percent of the cancers were microscopically verified and 12% were ascertained through death certificate only. The risk of colon cancer increased significantly with intestinal dose, but no definite increase of risk was observed for rectal cancer. Relative risk at 1 Sv and excess risk per 10(4) PY-Sv for colon cancer are 1.80 (90% confidence internal 1.37-2.36) and 0.36 (90% confidence interval 0.06-0.77) respectively. City and sex did not significantly modify the dose-response of colon cancer, but the risk decreased with age at the time of bombings (ATB). The relative risk of colon cancer does not vary substantially over time following exposure. A non-linear dose response did not significantly improve the fit. Further, the anatomic location of the tumors indicate that the cecum and ascending, transverse and descending, and sigmoid colon seem equally sensitive to radiation. No difference in the distribution of tumor histological types could be observed by radiation dose.

No abstract

Perforation of the stomach is the most uncommon complication of cancer of the stomach and was found in 9 of 1,620 patients treated over a 23-year period. The 5-year survival rate of 62.8% indicates that aggressive surgical treatment should be applied where possible. In some patients, radical resection is performed as a second procedure after recovery from the acute episode of perforation.

Forty-nine patients with primary carcinoma of the liver were surgically treated at our hospital through 1961. Four cases with minute hepatocellular carcinoma which were subjected to liver resection were investigated.1. Twenty cases of this series underwent liver resection and their resectability was 41.7%. Of these 20 cases, 16 were concomitant with fibrosis or cirrhosis for back ground.Patients with such a cancer show poor prognosis and autopsy were performed on 10 cases.Histological findings showed marked proliferation of connective tissues and invasion of its fiber into the pseudolobules in the residual liver than the resected liver. Of 4 cases with minute hepatocellular carcinoma, 2 were positive serum AFP andHBs-Ag level and 3 were found tumor stain in hepatic arteriogram and low density area in hepatoscintigram.3. On gross specimen with minute cancer, all of them were of the single nodular type with capsule formation which were histologically found invasion of carcinoma. Tumors larger than 3.0cm in size revealed tumor necrosis, tumor thrombus in the portal vein and rupture of the hepatic capusules. Above findings indicated that those cases should be subjected to radical operation such as segmental resection or hepatic lobectomy.