Introduction: Diarrheal infections associated to multidrug resistant bacteria are a public health problem, particularly in the tropics. Objective: The aim of this study was to describe a Multidrug resistant strain of Escherichia coli (E. coli) isolated from diarrheal stools. Patients and methods: A sample of diarrheal stools from a 30 years old housekeeper patient was analysed at China-Guinea Friendship Hospital of Kipé/Conakry. Parasitological examination by optical microscopy, followed by bacteriological analysis were done. Cultures were carried out on different agar media. Bacterial identification, antibiograms and minimum inhibitory concentrations (MIC) were performed using the Vitek 2 System. Results: The isolated E. coli strain was sensitive only to 4 of 29 antibiotics tested including imipenem, ertapenem, amikacin and nitrofurantoin. Intermediate sensitivity was detected towards minocycline. In contrast, this strain was resistant to piperacillin, cefuroxime, cefuroxime axetil, cefixime, ceftriaxone, cefepime, aztreonam, meropenem, levofloxacin, ofloxacin, tetracycline, tigecycline, chloramphenicol, trimethoprim, ampicillin, amoxicillin/clavulanic acid, ticarcillin, piperacillin/tazobactam, cephalothin, cefotaxime, ceftazidime, gentamicin, tobramycin, nalidixic acid, ciprofloxacin, ofloxacin and trimethoprim/sulfamethoxazole with high MICs. Conclusion: The treatment of this multidrug-resistant Escherichia coli diarrheal infection requires appropriate antibiotic therapy, based on the results of an accurate antibiogram to be performed with rapid means for better patient care.

Introduction: Tuberculosis and HIV are real public health problems in the world and mainly in Africa. The current challenge is to be able to diagnose TB in all PLWHA, hence the interest in evaluating the effectiveness of GeneXpert MTB/RIF in the diagnosis of pulmonary TB. Method: This is a prospective cross-sectional and descriptive study of HIV-positive patients who came for consultation during the survey period which lasted six months, from 1 February to 7 August 2021, at the Ignace Deen National Hospital in Conakry and at the Gamal Abdel Nasser University in Conakry. Data were collected and analysed using Epi-info version 7.0, Pack Office 2013 (Word, Excel and Power point). Results: Out of 402 patients received, we recorded 112 positive cases, i.e. 28% and 290 negative cases, i.e. 72%. Fluorescence microscopy gave 16% and Ziehl-Neelsen microscopy gave 14% with sensitivities of 90%, 47% and 43% respectively. 104 sample patients were sensitive to Rifampicin, i.e. 92.86% against 08 cases of resistance, i.e. 7.14%. The male sex is more represented with 53% against 47% for the female sex. All the communes of Conakry were concerned, but the communes of Matoto and Ratoma were the most represented, respectively 31% and 23%. Patients from outside Conakry had a rate of 21%, the communes of Matam 11% and Dixinn 9%. Patients from the Commune of Kaloum were the least represented with 5%. Almost all socio-professional groups are affected. Commercial agents are the most represented with 31%, followed by workers with 22%, housewives with 15%, drivers with 10%, administrative agents with 9%, pupils/students with 7% and security agents with 6%. Also all age groups are affected by HIV-TB co-infection but with the highest prevalence in the 21 to 40 age group with 56% followed by the 41 to 60 age group with 30%. The age groups least affected are those under 20 and over 60 years of age, respectively 9% and 5%. Conclusion: The present study confirms a significantly higher validity of GeneXpert MTB/RIF than microscopy in the detection of TB and its place in the prediction of multidrug resistance. Its systematic use coupled with microscopy would allow better control of tuberculosis in HIV-infected individuals.

Introduction: Diabetes is a group of metabolic diseases characterized by chronic hyperglycemia resulting from a defect in insulin secretion or insulin action or both associated abnormalities. Objective: Our study aims to contribute in improving of health care of diabetic patients in the Municipality of Ratoma, Conakry, and Republic of Guinea. Methods: This study is a prospective and descriptive cross-sectional study lasting of 4 months, from February 16 to June 16, 2021. Results: The study involved 300 patients whose blood and urine were examined, 17% of the patients were positive, therefore diabetic. Glycosuria was positive on an empty stomach in 87%. Abnormal parameters were found as followed: Urobilinogen with 97%, Blood with 97%, Optical Density with 90%, Nitrite with 84%, pH with 83%, Ketone Bodies with 76%, Bilirubin with 73%, presence of Proteins in 75%, and Leukocytes in 71%. The evolution of diabetes in 20 patients with the HbA1c test, i.e. 32% and the majority of the 20 diabetic patients had HbA1c levels between 4 to 5.60% with 7 patients, i.e. 35% followed by those with rate between < 4% and 6.80% to 7.20% with 5 patients each, i.e. 25% (cumulative 50% of patients); 3 diabetic patients whose hemoglobin were severely affected by glucose had high HbA1c levels between 8.80 and 9.60%, i.e. 10%, and 1 patient with an HbA1c level of 11.40%, i.e. 5%. THBs were low in 20 patients, about 32%. This study found respectively: hyperleukocytosis (10%), hyperneutrophilia (10%), hypermonocytosis (16%), hyperlymphocytosis (13%) among the diabetic patients and alongside, 32 diabetic patients suffered from hypoleukocytosis (19%), hyponeutrophilia (8%), hypolymphocytosis (8%) and 35% from hypomonocytosis. Frustrated anemia were found in 75%, moderate anemia in 20% and severe anemia in 5%, while 25% of diabetic patients suffered from Microcytic anemia and 75% from Normocytic anemia and 15% of diabetic patients suffered also from Hypochromic anemia and 85% of diabetic patients suffered from Normochromic anemia. Female sex was the most represented with 59% against 41% for male sex. All age groups were affected by diabetes, however, age group of 61 to 80 years were the most affected with a prevalence of 38% followed by those of 41 to 60 years and 21 to 40 with respectively 35% and 22%. The least represented age group were less than or equal to 20 years old with 5%. Housewives with 35% were the most affected followed by Commercial Agents, Pupils/Students and Administrative Agents with 22%, 10% and 8% respectively. The Married were the most with a prevalence of 83% against 14% among Singles and only 3% among Widowed. The majority of patients were from the commune of Ratoma, i.e. a prevalence of 81% followed by those from Matoto with 9%. Patients from elsewhere accounted for only 5%. Conclusion: This study revealed that in diabetic patients