Introduction:Dipyrone is widely used in Brazil, which makes it relevant to assess its quality in its various formulations, to ensure the efficacy and safety. Objective: Tests were conducted to verify the quality of dipyrone sodium oral solution 500mg/mL in reference, generic and similar presentations marketed in Gurupi-Tocantins-Brazil. Material and Methods: Lots of five different brands of dipyrone oral solution were evaluated, being the reference drug (Ref), two generic (Gen1 and Gen2) and two similar (Sim1 and Sim2), at a concentration of 500 mg/mL. The analysis of the information printed on the labels and in package leaflet was based on the current resolutions. The physical-chemical tests were conducted in accordance with official pharmacopeia compendium. Results: Some differences in the content and form of the information to users in all samples were found, Sim2 totaled the highest number of mismatches (seven), followed by the Gen1 (five), Sim1 (three), Gen2 (two) and Ref (one). The results of physical-chemical tests remained within the acceptable limits, except the drip test, in which the Ref and Sim2 were outside the specified minimum threshold. Conclusion: The results of the information printed were not satisfactory, presenting differences in the format of the information available.The physical-chemical tests were satisfactory, with the exception of the drip test for Ref and Sim2 drugs.

Research that takes account of popular uses of medicinal plants, also in urban areas, is important records to subsidize health actions more effectively and safely and maintain the local cultural heritage, as advocated by the national policy of medicinal plants. This study aimed to survey the use of medicinal plants by residents of the municipality of Aliança the Tocantins. In 2011, semi-structured interviews were conducted with 70 informants in the urban environment, Aliança of Tocantins. Most claimed to have acquired knowledge about medicinal plants with parents and grandparents, 60% and 25.7%, respectively. 62.9% of the interviewees obtained the plants in their backyard and 30% in the backyard of neighbors or relatives. The families with the highest number of species were Lamiaceae with 4 species (40%), Asteraceae and Malvaceae with 2 species each (20%). There were 82 therapeutic properties about the species mentioned, with a higher number of citations for "other indications" (25.6%), such as pain in general, back pain, malaise, dizziness, among others. The most used form of preparation was tea (81.4%) and the leaf was the most used organ (81.4%). Of the informants, 61.4% prefer to use home remedies instead of industrialized medicines. The informants, even living in the urban environment (82.8%), still know and frequently use the local medicinal flora, this being an indication of strong local cultural appeal and feasibility of encouraging green backyards.

Gestational Diabetes is a condition characterized by hyperglycemia that provides a drop-in insulin performance in its appropriate receptors by hormones secreted by the placenta and fetus. The main fetal comorbidities are macrosomia, growth disorder, and congenital and maternal anomalies in gestational diabetes, preeclampsia, vascular injury, and post-gestational diabetes. This study addressed the possible treatments with medicinal plants in gestational diabetes. Medicinal plants that have the diabetic purpose were researched, however, many pregnant women use and do not know the effects that can happen for the fetus and also for itself, the plants used for this work is not satisfactory for pregnant women with diabetes, but for non-diabetics, some are beneficial for treating this pathology. It becomes necessary for people to know the effects of plants that are used to treat certain types of diseases because most often in great excess can be fatal. All of them presented satisfactory results in a study for diabetes mellitus in non-pregnant patients, but the study presented by Cow's Paw (Bauhinia forficata l.) in pregnant rats with diabetes showed harmful results in embryo implantation and there was no glycemic control, which leads us to investigate further under the use of all plants in the treatment of gestational diabetes.

Os distúrbios hepáticos são doenças ligadas ao fígado. Tendo em vista a gravidade destes distúrbios e as dificuldades em se estabelecer um tratamento para eles, decidiu-se propor um novo modelo de tratamento, utilizando a silimarina, uma planta que vem sendo utilizada desde os tempos antigos na cura de diversas doenças. Diante disso, o objetivo dessa pesquisa foi discutir o real impacto que a silimarina possui nos distúrbios hepáticos. Para isso, esse estudo teve como base uma revisão bibliográfica descritiva, ao qual foi fundamentada em trabalhos científicos já publicados entre os anos de 2018 a 2022 em língua portuguesa e que tratavam especificamente sobre a temática proposta. A coleta de dados se deu em base de banco de dados, tais como Google Acadêmico, Scielo, PubMed e Lilacs, do qual resultaram 21 trabalhos científicos analisados e divulgados no decorrer desse estudo. Nos resultados encontrados, ficou claro observar que a Silimarina contribui para melhorar o intestino e o sistema digestivo em geral; modulando o equilíbrio da microbiota (pelo estímulo a proliferação de lactobacillus e bifidobactérias, o que teria importante efeito papel imunomodulador). Ainda tem ação anti-hepatotóxica, isso significa, ter ativos de proteção ao fígado e por fim, ajuda no tratamento de doenças hepáticas.

According to the World Health Organization (WHO), COVID-19 is a viral disease transmitted from person to person, which has the fastest spread in the world. OBJECTIVE: This project aimed to analyze epidemiological aspects of COVID-19 in the municipality of Gurupi/TO. METHODOLOGY: The research was conducted by consulting the epidemiological bulletin of COVID-19 made available daily by VISAE, from March 16, 2020, to May 15, 2021, where we identified the evolution of positive cases, deaths, and gender identification of this population, and analysis of literature review on the subject. RESULTS: Of the 10,336 positive cases, 5,570 (53.89%) of the cases are female, 194 (7.13%) evolved to deaths, of these 70 (36.08%) were female and 124 (63.92%) were male. FINAL CONSIDERATIONS: From the results, it is visible the reduction in the numbers of positive cases for COVID-19 from April 2021, which can be taken into consideration the measures adopted through the Municipal Decrees, and in part to the beginning of the immunization process. Thus, the continuity of prophylaxis measures is essential for the control of the high chain of transmission in the municipality.