A surface‐layer representation of the lunar gravitational field has been derived dynamically from the analysis of Doppler observations on both polar and equatorial lunar orbiters. The force model contained 600 discrete masses located on the mean lunar surface between the approximate boundaries of ±60° latitude and ±95° longitude. The derived major mascons were generally in agreement with a model based on polar orbits alone. A technique for combining the discrete mass gravitational field for the front side with a spherical harmonics expansion for the back side is described. Harmonic analysis of the resultant field shows that the higher end of the power spectrum roughly follows the decay rule predicted by W. M. Kaula in Nicolaides et al. [1963].

Recurrent clear cell ovarian carcinoma is a difficult to treat condition and early trial data has suggested a possible role for immune checkpoint inhibitors. Nivolumab is an anti-PD-1 immunotherapy that has been used in this setting. While immune related toxicity of these agents has been well described, the occurrence of immune specific neurotoxicity is thought to be rare. We present a case of severe encephalitis while on PD-1 immunotherapy for a recurrent ovarian clear cell cancer and we believe this to be the first such reported case associated with the use of PD-1 inhibitor monotherapy. In this case, a 64-year-old woman with persistent clear cell ovarian cancer on Nivolumab presented with a severe fever of unknown origin and delirium; initial imaging and diagnostic work-up suggested a neurological etiology, but with no clear source. We concluded that this was a severe case of immune related encephalitis, thought to be brought about by the anti-PD-1 immunotherapy which responded well to systemic corticosteroids and plasmapheresis and the patient able to make a full recovery. We present a summary of the case and its management as well as a review of the literature on the previously reported neurotoxicity's of PD-1 inhibitors.

The magnitudes of 92 surface mass points at designated locations were estimated from the radio tracking data of the Mariner Mars 1971 (M9) orbiter. This result is the first mass point model of a global field. The derived surface mass distribution correlates positively with the visible topography. The Hellas basin contains a mass deficiency, in contrast to some of the lunar basins which contain mass excesses. The Mars gravity field represented by the four parameters of an optimally located mass point (superimposed on an oblate spheroid) has third‐ and fourth‐degree harmonics comparable to those of the Complete model.

No abstract

No abstract