Graphene oxide (GO)-based theranostic nanohybrid is designed for tumor induced imaging and potential combinational tumor therapy. The anti-tumor drug, Doxorubicin (DOX) is chemically conjugated to the poly(ethylenimine)-co-poly(ethylene glycol) (PEI-PEG) grafted GO via a MMP2-cleavable PLGLAG peptide linkage. The therapeutic efficacy of DOX is chemically locked and its intrinsic fluorescence is quenched by GO under normal physiological condition. Once stimulated by the MMP2 enzyme over-expressed in tumor tissues, the resulting peptide cleavage permits the unloading of DOX for tumor therapy and concurrent fluorescence recovery of DOX for in situ tumor cell imaging. Attractively, this PEI-bearing nanohybrid can mediate efficient DNA transfection and shows great potential for combinational drug/gene therapy. This tumor induced imaging and potential combinational therapy will open a window for tumor treatment by offering a unique theranostic approach through merging the diagnostic capability and pathology-responsive therapeutic function.

A graphene oxide hydrogel (GOH) is fabricated via suspending the graphene oxide (GO) in water without any additional processing steps. At the hydrogel/air interface, a well‐defined hydrogel membrane forms once the solvent is removed by vacuum drying. The microstructure of the resulting GOH film can be tailored by different dehydration approaches, as well as by varying the GO concentration in the hydrogel. This GOH exhibited pH‐responsiveness and good mechanical properties. Meanwhile, the GOH presented good adsorption capacity to the organic dye rhodamine B and anionic chromate Cr2O72−. This GOH may find great potential in many fields, such as wastewater treatment, biodetection, etc.

Neurodegenerative diseases including Alzheimer's, Parkinson's, and type II diabetes are recognized to be related to proteins misfolding into amyloid fibrils and other aggregates with a b-sheet conformation.Herein, self-assembled peptide micro/nanoarchitectures were designed and prepared to mimic those aggregates. A short b-amyloid peptide derivative with a diphenylalanine moiety was synthesized, which could self-assemble into nanofibers via b-sheet conformation in an aqueous solution with a concentration of 1 mg mL À1 at pH about 8. By adjusting the pH to around 6.5, a peptide solution with a concentration of 15 mg mL À1 could change to a supramolecular hydrogel. The influence of selfassembly conditions including peptide concentration, temperature, pressure, and self-assembly time were investigated in detail. It was found that the self-assembled nanofibers could further aggregate into catenulate microfibers in solution as well as layer-by-layer plaques in the hydrogel under particular conditions.

Hydroxyapatite (HA) is the most commonly used orthopedic implant material. In recent years, the emergence of cationic doped hydroxyapatite has revealed more possibilities for the biological application of HA. Conventional...