The North Atlantic and Southern Ocean exhibit enhanced ocean heat uptake (OHU) during recent decades while their future OHU changes are subject to great uncertainty. Here, we show that regional OHU patterns in these two basins are highly dependent on the trajectories of aerosols and greenhouse gases (GHGs) in future scenarios. During the 21st century, North Atlantic and Southern Ocean OHU exhibit similarly positive trends under a business-as-usual scenario but respectively positive and negative trends under a mitigation scenario. The opposite centurial OHU trends in the Southern Ocean can be attributed partially to distinct GHG trajectories under the two scenarios while the common positive centurial OHU trends in the North Atlantic are mainly due to aerosol effects. Under both scenarios, projected decline of anthropogenic aerosols potentially induces a weakening of the Atlantic Meridional Overturning Circulation and a divergence of meridional oceanic heat transport, which leads to enhanced OHU in the subpolar North Atlantic.

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