A compact aperture coupled patch type microstrip‐to‐waveguide transition at V‐band is proposed and fabricated using low‐temperature cofired ceramic process. It uses the aperture coupled microstrip feed and the parasitic patch antenna radiating into the waveguide to improve the insertion loss and the bandwidth. As a result of experiments, low‐transmission loss and high‐return loss are realized at the design frequency of 60 GHz. For a 10‐dB return loss, a relative bandwidth of 13.8% is obtained for a fabricated back‐to‐back transition. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 433–435, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24941

MicroRNA (miR)-21, -17-92 cluster and -155 have been known to play important roles in the development and progression of various cancer types. However, effects of their expression level on the patient's prognosis in diffuse large B cell lymphoma (DLBCL) have not been fully elucidated. Thus, we investigated the association of miR-21, -17-92 cluster and -155 expressions with clinicopathologic features and prognosis in patients with DLBCL. Quantitative real-time reverse transcriptase-polymerase chain reaction analysis was performed to evaluate the expression level of miR-21, -17-92 cluster and -155 in 200 cases of DLBCL, and 11 tonsils as control, using formalin-fixed paraffin-embedded tissues. Role of miR-21 in DLBCL was also analyzed using several DLBCL cell lines. MiR-21, -17-92 cluster and -155 expressions were significantly increased in DLBCL compared with control (p=0.012, p=0.001 and p<0.0001, respectively). MiR-21 up-regulation was more frequently observed with higher stage (p=0.004) and higher International Prognostic Index (IPI) (p=0.043) and miR-17-92 cluster up-regulation was more common with older age (p=0.019) and higher performance status (PS) (p=0.012). Moreover, miR-21 and -17-92 cluster up-regulations were significantly associated with decreased progression free survival (PFS) (p=0.001 and p=0.014, respectively) and overall survival (OS) (p=0.002 and p=0.012, respectively). In the Cox proportional hazard model, overexpression of miR-21 was found to be an independently poor predictor for OS (HR=1.72; p=0.043). Importantly, high miR-21 expression showed stronger prediction for OS in rituximab treated (HR=2.62; p=0.017) and germinal center B-like (HR=11.91; p<0.001) subgroups. MiR-21 expression was inversely correlated with PTEN and FOXO1 expression in DLBCL cell lines. PTEN and FOXO1 expressions were increased by inhibition of miR-21 in SU-DHL4 and SU-DHL5 cell lines. Inhibition of miR-21 suppressed cell proliferation and sensitized these cells to doxorubicin cytotoxicity, which was accompanied by down-regulation of phospho-Akt. In addition, Bim, a transcriptional target of FOXO1, was increased by miR-21 inhibitor at the transcriptional level. Expression and functional activity of MDR1, which is known to be up-regulated by mTOR, were suppressed by miR-21 inhibitor. Together these data suggest that miR-21 might contribute to activation of PI3K/Akt pathway by down-regulating PTEN at an upstream level, and moreover suppress the expression of FOXO1, a tumor suppressive transcription factor at a downstream level, putatively in a direct and indirect manner. In conclusion, up-regulation of miR-21 is considered to play an important oncogenic role in DLBCL and have a strong prognostic implication. Citation Format: Heounjeong Go, Ji-Young Jang, Soo Jeong Nam, Young-Goo Kim, Jin Ho Paik, Tae Min Kim, Dae Seog Heo, Chul-Woo Kim, Yoon Kyung Jeon. MiR-21 has strong prognostic implications and functions as an oncogenic miR by modulating PI3K/Akt pathway at multiple levels in diffuse large B cell lymphoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 1490. doi:10.1158/1538-7445.AM2014-1490

In this paper, the improved power durability test system and method for an reliability analysis of SAW device is proposed and the failure mechanism through failure analysis is analyzed. As a result of the failure analysis using microscope, SEM and EDX, the failure mechanism of the SAW device is electromigration due to joule heating under high current density and high temperature condition. The electromigration makes voids and hillocks in the IDT electrode and the voids and hillocks can lead to short circuit and open circuit faults, respectively, increasing the insertion loss of an SAW filter. The accelerated life testing of the SAW filter for 450MHz CDMA application using the proposed power durability test system and method is carried out. B10 lifetime of the SAW filter using Eyring model and Weibull distribution is estimated as about 98,500 hours.

In this paper, we propose an allocation scheme for variable message packings to increase efficiency of military operation using Link-16 which is well-known for tactical data link by delivering imagery information rapidly. We propose a variable message packing scheme using COC waveform to support variable data rate under some coverage limitation. Variety of message packing makes Link-16 vary transmission rate appropriately for tactical environment. We also propose a allocation scheme to assign message packing to time slot properly.Finally we verify the performance and superiority of proposed ideas by simulations.

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