This article provides a systematic review of studies on the composition of leech saliva secretions, the method of hirudotherapy, and the results of hirudotherapy in complex treatment. The following databases were used to search for the study: Scopus, Web of Science, MedLine, and Global Health. When using known methods of treatment, there is often no stability of results, this is explained by the search for new drugs and methods for treating periodontitis. It is known that the secret of the salivary glands of the medical leech contains more than 100 biologically active substances. The therapeutic effect of hirudotherapy is associated with the mechanical discharge of blood flow and the action of a complex salivary gland secretion of a medical leech. The molecules that exist in leech saliva and are the most studied to date include active substances such as hyaluronidase, hirudin, Kalin, destabilase, bdellins, histamine-like substances, hirustazine, factor XA inhibitor, and collagenase. It is scientifically proven that hirudotherapy leads to a significant improvement in the clinical condition of periodontal tissues, is simple, accessible, and can be recommended for use in the practice of periodontists.

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The relevance of the study is determined by the need to attract private investment in the field of municipal health care with the aim of improving the system of outpatient urological care.Purpose. To determine the vectors of development, planning, the basic conditions for the implementation of municipalprivate partnership (IMPP) in the system of municipal outpatient urological care.Materials and methods. To achieve this goal, general scientific methods of analysis, synthesis, generalization, interpretation of scientific data, as well as systemic and structural-functional approaches were applied in the work.Results. The article provides the scientific substantiation of the role of municipal-private partnership in the development of municipal outpatient urology. Methodical approaches to the formation of the outpatient center of urology with the mechanisms of the mixed economy, developing business processes involving private investor resources in the reproduction processes and increasing the efficiency of the municipal system of outpatient urological care are outlined.Conclusions. The article defines the vectors of development, planning, the main conditions for the implementation of municipal-private partnershipsin the system of municipal outpatient urological carein order to attract privateinvestments and develop an outpatient urology system.

The main treatment for cervical cancer are surgery, radiation and combined (surgery + radiotherapy), the role of chemotherapy in this localization is studied less fully. In recent years the new possibilities of chemotherapy, including neoadjuvant intraarterial chemotherapy, are explored. Theoretical prerequisites for this are the best drug delivery to the tumor by blood vessels, undamaged due to radiation therapy and surgery. This paper describes a clinical case of a patient with primary inoperable cervical cancer. As an alternative to preoperativ e radiotherapy the patient was proposed neoadjuv ant com bination chemotherapy with the use of regional administration of platinum drugs and systemic administration of drugs of taxan series as a stage of preparation for further surgical treatment. According to the prevalence of the tumor process patient underwent 2 courses of neoadjuv ant chemotherapy by a method of superselective intra-arterial administration of cisplatin and paclitaxel intravenously. According to a comprehensive examination after treatment data for the presence of tumor was absent. During the second stage the patient underwent surgical treatment in the volume of nerve-sparing radical hysterectomy with appendages. The next step, according to the histological form of the tumor, stage of disease, was the radiotherapy in the postoperative period on the pelv ic area and routes of lym ph drainage. The patient underwent external beam radiotherapy to the pelvic area of FD = 20 Gr, intracavitary gamma-therapy and external beam radiation on the area of parametrial and lymphopenia FD = 50 Gr.The patient passed the control examinations every 3 months. According to a comprehensive survey a year after the start of treatment — there is no data for the presence of recurrence and spread of tumor process.

INTRODUCTION. The problem of preventing massive pulmonary thromboembolism and post-thrombotic syndrome in deep vein thrombosis has been studied for a long period. The introduction of new treatments for deep vein thrombosis requires a detailed comparison of their effectiveness.The OBJECTIVE of this work was a comparative analysis of ligation of the superficial femoral vein and regional thrombolytic therapy.MATERIAL AND METHODS. A retrospective multicenter study involving 30 patients with femoproplite thrombosis, who had received catheter-directed thrombolysis or ligation of the superficial femoral vein, was performed. The investigated patients underwent inpatient treatment.RESULTS. The data on the effectiveness of both methods in preventing pulmonary thromboembolism were obtained. When comparing both groups, we revealed a statistically significant difference in the frequency of the development of PTS and the severity of its development in 1 year after treatment. With ligation vein, 73.3 and 6.7% in the thrombolysis group (p=0.0005).CONCLUSION. Regional thrombolysis was an effective treatment for deep vein thrombosis and prevention of PTS.The authors declare no conflict of interest.The authors confirm that they respect the rights of the people participated in the study, including obtaining informed consent when it is necessary, and the rules of treatment of animals when they are used in the study. Author Guidelines contains the detailed information.