This article provides a systematic review of studies on the composition of leech saliva secretions, the method of hirudotherapy, and the results of hirudotherapy in complex treatment. The following databases were used to search for the study: Scopus, Web of Science, MedLine, and Global Health. When using known methods of treatment, there is often no stability of results, this is explained by the search for new drugs and methods for treating periodontitis. It is known that the secret of the salivary glands of the medical leech contains more than 100 biologically active substances. The therapeutic effect of hirudotherapy is associated with the mechanical discharge of blood flow and the action of a complex salivary gland secretion of a medical leech. The molecules that exist in leech saliva and are the most studied to date include active substances such as hyaluronidase, hirudin, Kalin, destabilase, bdellins, histamine-like substances, hirustazine, factor XA inhibitor, and collagenase. It is scientifically proven that hirudotherapy leads to a significant improvement in the clinical condition of periodontal tissues, is simple, accessible, and can be recommended for use in the practice of periodontists.

This article provides a systematic review of studies on a new biological treatment method called regenerative endodontic technique. Databases of Scopus, Web of Science, and MedLine were searched for relevant studies. Dental trauma most common occurs in children and the most common cause of the loss of viability of the pulp of permanent teeth with incomplete root development. Treatment of these teeth takes time and technically complex. Thus, a technique was proposed that could use the potential of apical papilla stem cells, leading to the refilling of the root canal with vital tissue through the regenerative endodontic technique. It is necessary to pay due attention to the use of regenerative endodontic techniques, especially in cases where the root development is incomplete. The use of mineral trioxide aggregate is unlikely to improve the condition of the tooth.

No abstract

This article presents a review of studies that have focused on the technology of minimally invasive caries removal, endodontic treatment, and dental restoration. Databases of Scopus, Web of Science, and MedLine were searched for relevant studies. With ongoing comprehensive investigation of various diseases, present-day medicine has changed from using a biomedical model to a biopsychosocial medical model, so increasing attention is being paid to the concept of minimally invasive treatment in dentistry. The concept of minimally invasive technology has given rise to a number of minimally invasive methods for the diagnosis and treatment of oral diseases. Taking into account the psychology, health status, function, and aesthetics of the patient, minimal intervention is required. Children, as a special group of patients, are in the period of the initial formation of their psychological structure. In this regard, the goal of dental treatment of children should not be limited to restoring functions and relieving pain; it is also worth paying attention to their development and physical and mental health. Therefore, in recent years, minimally invasive technology has gradually been used in the diagnosis and treatment of oral diseases in children.