An analysis of the world experience of military conflicts of the last century and the results of repulsing the full-scale armed aggression of the Russian Federation indicates the need to strengthen the defense capability of the state by improving the methods and mechanisms of comprehensive support. Studies prove that the basis for the provision of the defense capability of the state and the capabilities of the defense forces is the management of defense resources as an integral part of strategic (defense) planning. Consequently, the management of defense re-sources is a priority nationwide measure which involves the components of the Security and De-fense sector of Ukraine (hereinafter referred to as the SDSU), other ministries and executive authorities, the limits of competence of which extend to the issues related to the defense sphere of the country. The article suggests some ways to strengthen the defense potential of the state and increase the efficiency of the Armed Forces of Ukraine through the use of a high-tech in-formation system (IS). A complex and important issue of this management activity is to ensure the coordination of actions of state bodies of the SDSU, achieving the necessary balance be-tween the volume and nature of the tasks assigned to the Ministry of Defense of Ukraine, the Armed Forces of Ukraine and other components of the SDSU, the capabilities of the state for their resource provision, activities and volumes of international military-technical and financial assistance. The Unified Information System for the Management of Defense Resources of the Armed Forces of Ukraine (UIS MDR AFU) can be such an IS, which will increase the efficiency of state and military administration and improve the mechanisms for managing defense re-sources. Under the current conditions, in order to significantly improve the organization and implementation of activities for the management of defense resources, all components of the SDSU must be equipped with the appropriate software and technological tools – the UIS MDR AFU. The formation and use of the prospective UIS MDR AFU should be aimed at solving the problems of defense provision, effective use of the potential of the state, as well as the imple-mentation of measures to strengthen the defense capability of the state in the direction of MDR.