The aim of the present study was to determine the efficacy of transvaginal color flow imaging as a screening tool for ovarian cancer. Six hundred patients with previous breast carcinoma were screened for ovarian cancer. Screening was performed using transvaginal sonography with color flow imaging. Serum CA 125 levels were measured in patients with abnormal sonographic findings. Eighty-three percent of the ovaries were detected in the premenopausal patients by ultrasonographic scanning and only 26% of the ovaries were detected in the postmenopausal patients. Intraovarian blood vessels were detected in 11% of the premenopausal women. The PI was less than 1 in 80% of these ovaries, but, on repeated examinations, the values of PI increased in all the blood vessels to greater than 1. Intraovarian blood vessels were detected in 1.8% of the normal ovaries observed in the postmenopausal women, but PI was always greater than 1. Eleven women with complex ovarian cysts (not simple) and one woman with enlarged ovaries underwent explorative laparotomy. In three women, primary malignant ovarian tumors were diagnosed and in one woman metastatic ovarian cancer was diagnosed. The specificity of sonography in detecting malignant ovarian tumors was 97.5% and the positive predictive value was 25%. The specificity of color flow imaging in detecting primary malignant ovarian tumors was 99.8% and the positive predictive value was 60%. In selected groups of women, screening for ovarian cancer with transvaginal color flow imaging may be justified.
It has been indicated that a complex of basic therapy for patients with COPD should include initial vaccination with PCV13, followed by administration of a booster dose of PPV23.
1 -Федеральное государственное бюджетное образовательное учреждение высшего образования «Самарский государственный медицинский университет» Министерства здравоохранения Российской Федерации: 443099, Самара, ул. Чапаевская, 89; 2 -Федеральное государственное бюджетное научное учреждение «Научно-исследовательский институт вакцин и сывороток им. И.И.Мечникова»: 105064, Москва, Малый Казенный пер., 5А; 3 -Федеральное государственное автономное образовательное учреждение высшего образования «Первый московский государственный медицинский университет им. И.М.Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский университет): 119991, Москва, ул. Трубецкая, 8, стр. 2 Информация об авторах Протасов Андрей Дмитриевич -к. м. н., доцент кафедры общей и клинической микробиологии, иммунологии и аллергологии, врач аллергологиммунолог Федерального государственного бюджетного образовательного учреждения высшего образования «Самарский государственный медицинский университет» Министерства здравоохранения Российской Федерации; Жестков Александр Викторович -д. м. н., профессор, заведующий кафедрой общей и клинической микробиологии, иммунологии и аллергологии Федерального государственного бюджетного образовательного учреждения высшего образования «Самарский государственный медицинский университет» Министерства здравоохранения Российской Федерации;
The pandemic of the novel coronavirus infection has posed additional challenges for endoscopy services. Endoscopy departments face a high risk of spreading airborne respiratory diseases in their daily work. This is especially true for endoscopic departments and offices that perform bronchoscopic examinations. The world scientific community recognizes the highest epidemiological risk of personnel infection during any interventional manipulations and operations related to the respiratory system, including bronchoscopic interventions.
The objective: development of the best vaccination regimen against pneumococcal infection in patients with chronic obstructive pulmonary disease (COPD) with consideration of changes in microbiological and clinical parameters.Subjects and Methods. 115 patients with COPD were randomized into 4 pneumococcal vaccination groups, they were examined and followed up for 4 years; 112 patients completed the study complying with the protocol. Detail medical history of all subjects was collected. To verify the diagnosis of COPD, all subjects underwent external respiratory function test and bronchodilator test (salbutamol, 400 μg) according to the standard method. The classic microbiological assessment was used in this study. The clinical effectiveness of vaccination was assessed. Statistical processing of the results was performed using StatPlus Pro 6.2.0.0 software (license number 2883).Results. Сonsecutive vaccination with pneumococcal conjugate and polysaccharide vaccines leads to decreased isolation rate of pneuniococcus from the sputum of CODP patients. The frequency of exacerbations, the need for antibiotic chemotherapy and hospitalizations also goes down.
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