Introduction: Creation of modern information systems for supervision of the state of health of the population is impossible without effective monitoring of the state of individual health, the implementation of a comprehensive assessment of risk factors and the development of recommendations for the preservation of the health of individuals. The aim: Determination of the peculiarities of the interaction between the indicators of the psychophysiological adaptation of students during the асademic year and throughout the period of stay in a higher medical education institution in the context of providing effective monitoring of the individual health of young women and young men. Materials and methods: A set of psychophysiological functions of the organism of the students was investigated by instrumental techniques and computer diagnostic complex “Effecton Studio”, applying of standardized t questionnaires the characteristics of the person were determined, and the prognostic evaluation of the obtained data was carried out with factor analysis procedures. Results: It was determined that the following factors should be noted as the main factor formations during the analysis of the physiologically-determined correlates of processes psychophysiological adaptation: peculiarities of dynamic performance, balance of nervous processes and mobility of nerve processes, and mentally-determined correlates of processes psychophysiological adaptation: peculiarities of temperament and anxiety, character properties, level of subjective control of personality, aggressive manifestations of personality and emotional burnout. Conclusions: In the study were determined the most peculiarities of the interaction of the indicators of psychophysiological adaptation of modern students in the context of providing efficient monitoring of individual health.

The aim: To find out typical pathomorphological differences in placenta of women with early and late preeclampsia. Materials and methods: Investigation includes 40 placentas from deliveries in women with preeclampsia (main group) and 40 placentas from physiological delivery in somatically healthy women, who had no complications during pregnancy (control group). Placentas in the main group were devided into two sub-groups (20 in each) – with early and late preeclampsia. Specialties of the blood vessels in normal pregnancy were investigated, and their structural transformation with the developement of preeclampsia, according to the appearence of perinatal pathology. Morphometrical data of the blood stream was investigated with the help of eyepiece and program Image Tools 3,6. Results: Significant decrease of weight (p<0,05), square and volume of placenta was common to early preeclampsia, comparing to the same characteristics in late Preeclampsia (PE). Specific gravity of villi without vessels, hardened blood vessels, hardened villi and fibrinoid altered vessels was increased statistically significantly (p<0,05) in placenta of women with early PE, comparing to women with late PE. The number of effective blood vessels crossings was determined mostly in late PE, comparing to the early form (p<0,05). Found out significant defferences (p<0,05) in changes of hystovasoarchitecture of placenta in early preeclampsia, according to the number of immature villi and villi with no signs of compensatory angiomatosis. Conclusions: Increased number of hypoplasia of placenta, breach of effective placental blood stream and significant decrease of compensatory and adaptive changes in placenta are more common to early PE, comparing to late PE.

Hypertensive disorders of pregnancy are a leading cause of maternal morbidity and mortality worldwide, accounting for more than 70,000 maternal deaths each year. Of all maternal deaths, 10–15% are directly associated with preeclampsia (PE) and eclampsia. The new version of the Ukrainian National Clinical Guideline and Clinical Protocol «Hypertensive disorders during pregnancy, childbirth and the postpartum period» 2022 presents a synthesis of the scientific evidence that is relevant to the concerning severe PE treatment strategies. It was presented the new algorithm of clinical management for severe pre-eclampsia «CALM DOWN» that implemented to the new Ukrainian clinical protocol of primary, secondary (specialized) and tertiary (highly specialized) medical care. CALM DOWN is the special mnemonic that means «step by step strategy» for the medical teamwork. Conclusions. The algorithm «CALM DOWN» have been proposed for the optimal timing of severe PE, offers to systematize the participation of each member of the team in the provision of emergency care and should be implemented in clinical practice based on the peculiarities of the specifics of work, resources, functioning and localization of the maternity facilities when forming personal route of the patient.

Research aim was to identify differences in anthropometric, somatotypological and components of body weight between the respective groups of healthy teenager girls and patients with primary dysmenorrhea. Identifying such relationships will identify risk groups for primary dysmenorrhea and prevent its occurrence in adolescent girls.Materials and methods. All materials presented in the article are part of the dissertation “Prognosis, diagnosis and prevention of primary dysmenorrhea in patients of pubertal age with different somatotypes.” Authors analyzed the indicators of 270 teenager girls, among which 200 persons were almost healthy and 70 patients with primary dysmenorrhea. For examination were used questionnaire-anamnestic method, measurement of anthropometric, somatotypological, components of body weight, ultrasound examination of the pelvic organs in two cycle phases and hormonal profile examination in the follicular and luteal phase of the menstrual cycle and statistical research methods. Results. Comparing anthropometric, somatotypological and components of body weight between the relevant (general or somatotype) groups of healthy girls and patients with primary dysmenorrhea, between the general group with primary dysmenorrhea and girls with primary dysmenorrhea of different somatotypes, as well as between patients with primary dysmenorrhea different somatotypes found significant differences (p <0.05) or tendencies of differences (p = 0.05) among total body size, body circumference, torso diameter, width of the distal epiphyses of the long tubular bones of the extremities, thickness of skin and fat folds, somatotype components, indicators of body weight composition.Conclusions. Medicine of the future will be preventive, aimed to identify predictors of pathology, factors influencing the development of nosology, and individual characteristics of teenage girls, which may lead to etiological and pathogenic impulse of clinical progression of primary dysmenorrhea. Therefore, the identification of prognostic markers of primary dysmenorrhea and formation of risk groups can improve not only life quality of a particular girl, but also the reproductive potential of nation.

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