новые воЗможности хирургичесКого лечения паЦиентоК с первично нереЗеКтабельным раКом ШейКи матКи и.а. Косенко 1 , т.м. литвинова 2 , о.п. матылевич 1 ГУ «Республиканский научно-практический центр онкологии и медицинской радиологии им. Н.Н. Александрова», г. Минск 1 УО «Белорусский государственный медицинский университет», г. Минск 2 223040, Минский р-н, а.г. Лесной, Республика Беларусь.

In the article the contents of different oncogenous strains of human papillomavirus (HPV) have been studied: in 50 patients with non-resectable cervical carcinoma, 26 patients before chemotherapy: systematic (cisplatin and gemcitabin) and local with injection of gemcitabin into uterine arteries. It has been established, that among non-resectable cervical carcinomas HPV-16 is the most prevalent type, whereas the other types are scarcely diagnosed. The application of 2 chemotherapy courses, even if one of them is local with the injection of cytostatic into uterine arteries, does not lead to the eradication of HPV oncogenous strains in the patients with non-resectable cervical carcinoma.

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Background. Malignant tumors management using conventional treatment modalities is associated with poor outcomes. Objective of the study. To assess photodynamic activity of Photolon as monotherapy, as well as in combination with radio- and chemotherapy in an experiment.Material and methods. The research was done on HeLa monolayer culture (human uterine cervix carcinoma), 97 white random-bred rats with Pliss lymphosarcoma and 42 mice (CBA) with uterine cervix cancer-5 (UCC-5). Results. The amplification factor in Photolon photoirradiation was 65.1 in terms of the cytostatic effect and 98.5 in terms of cytotoxic effect. Photodynamic therapy enhances the efficacy of radiotherapy, since it reduced Pliss lymphosarcoma growth rate in rats down to 33.7% and UCC-5 growth rate in mice down to 14.9% of the intact control level (p<0.05). Conclusion. It is advisable to include photodynamic therapy in multimodality treatment.