131. The constitution of oroxylin-A, a yellow colouring matter from the root-bark of Oroxylum indicum, vent

Shah, Rahul; Mehta, C. R.; Wheeler, T. S.

doi:10.1039/jr9360000591

Cited by 16 publications

(3 citation statements)

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“…Oroxylin A (Fig. ) is an O ‐methylated flavone extracted from medicinal plants Scutellaria baicalensis and Oroxylum indicum tree which has been reported as a potential anticancer drug. Oroxylin A suppressed cell proliferation and caused apoptosis in colon carcinomas through the suppression of IL‐6/STAT3 pathway, also this pathway was mitigated in oroxylin‐A‐treated animals .…”

Section: Pps Targeting Stat3mentioning

confidence: 99%

STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma

et al. 2016

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Melanoma or malignant melanocytes appear with the low incidence rate, but very high mortality rate worldwide. Epidemiological studies suggest that polyphenolic compounds contribute for prevention or treatment of several cancers particularly melanoma. Such findings motivate to dig out novel therapeutic strategies against melanoma, including research toward the development of new chemotherapeutic and biologic agents that can target the tumor cells by different mechanisms. Recently, it has been found that signal transducer and activator of transcription 3 (STAT3) is activated in many cancer cases surprisingly. Different evidences supply the aspect that STAT3 activation plays a vital role in the metastasis, including proliferation of cells, survival, invasion, migration, and angiogenesis. This significant feature plays a vital role in various cellular processes, such as cell proliferation and survival. Here, we reviewed the mechanisms of the STAT3 pathway regulation and their role in promoting melanoma. Also, we have evaluated the emerging data on polyphenols (PPs) specifically their contribution in melanoma therapies with an emphasis on their regulatory/inhibitory actions in relation to STAT3 pathway and current progress in the development of phytochemical therapeutic techniques. An understanding of targeting STAT3 by PPs brings an opportunity to melanoma therapy. © 2016 BioFactors, 43(3):347-370, 2017.

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Section: Pps Targeting Stat3mentioning

confidence: 99%

STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma

et al. 2016

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“…Oroxylum indicum has been used for centuries as a traditional medicine in Asia for the prevention and treatment of several diseases, such as, respiratory diseases, arthritis, rheumatism, diabetes, and diarrhea ( Dinda et al ., 2015 ), and oroxylin A, a major flavonoid in the stems and root bark of Oroxylum indicum , has been reported to inhibit the growth of lung, breast, colon, glioma, and hepatocarcinoma cells ( Dai et al ., 2013 ; Qiao et al ., 2015 ; Wei et al ., 2015 ; Zou et al ., 2015 ; Wei et al ., 2016 ). In addition, this flavone has also been found in roots of Scutellaria baicalensis , which is also used in traditional medicine ( Shah et al ., 1936 ; Li and Chen, 2005 ; Li et al ., 2011 ). In mouse macrophages treated with lipopolysaccharide, oroxylin A ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Anti-Allergic Effect of Oroxylin A from Oroxylum indicum Using in vivo and in vitro Experiments

Lee

Kang

Park

et al. 2016

Biomol Ther (Seoul)

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Oroxylum indicum has long been used in Asian traditional medicine to prevent and treat respiratory diseases, diabetes, diarrhea and other conditions. Oroxylin A is a flavone that is present in Oroxylum indicum and in Scutellaria baicalensis. Because the root extracts of both plants have been shown to have anti-allergic effects, the authors investigated whether oroxylin A is likely to have beneficial effects on allergic asthma using female Balb/c mice and rat RBL-2H3 mast cells. Antigen-induced degranulation was measured in vitro by measuring β-hexosaminidase activity. A murine ovalbumin-induced allergic asthma model was used to test the in vivo efficacy of oroxylin A. Sensitization and challenge of ovalbumin induced allergic asthma responses, the accumulations of eosinophils and Th2 cytokine levels in bronchoalveolar lavage fluid and lung tissues. Oroxylin A administration decreased numbers of inflammatory cells, especially eosinophils, and reduced the expression and secretion of Th2 cytokines, including IL-4 and IL-13, in lung tissues and bronchoalveolar lavage fluid. Histologic studies showed oroxylin A reduced inflammatory signs and mucin production in lungs. These findings provide evidence that oroxylin A has potential use as an anti-allergic therapeutic.

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“…OA is mainly found in the root-bark O. indicum, S. baicalensis ( radix ), S. lateriflora, Anchietea pyrifolia, and Aster himalaicus, which are used extensively in Ayurveda and TCM [ 40 ]. The crude extract of OA was first isolated from O. indicum using alcohol percolation and distillation [ 52 ]. Later, OA was isolated by acetone extraction followed by crystallization, which gave rise to the yield of only 0.86.…”

Section: Isolation and Purification Of Oamentioning

confidence: 99%

Oroxylin A: A Promising Flavonoid for Prevention and Treatment of Chronic Diseases

et al. 2022

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There have been magnificent advancements in the understanding of molecular mechanisms of chronic diseases over the past several years, but these diseases continue to be a considerable cause of death worldwide. Most of the approved medications available for the prevention and treatment of these diseases target only a single gene/protein/pathway and are known to cause severe side effects and are less effective than they are anticipated. Consequently, the development of finer therapeutics that outshine the existing ones is far-reaching. Natural compounds have enormous applications in curbing several disastrous and fatal diseases. Oroxylin A (OA) is a flavonoid obtained from the plants Oroxylum indicum, Scutellaria baicalensis, and S. lateriflora, which have distinctive pharmacological properties. OA modulates the important signaling pathways, including NF-κB, MAPK, ERK1/2, Wnt/β-catenin, PTEN/PI3K/Akt, and signaling molecules, such as TNF-α, TGF-ꞵ, MMPs, VEGF, interleukins, Bcl-2, caspases, HIF-1α, EMT proteins, Nrf-2, etc., which play a pivotal role in the molecular mechanism of chronic diseases. Overwhelming pieces of evidence expound on the anti-inflammatory, anti-bacterial, anti-viral, and anti-cancer potentials of this flavonoid, which makes it an engrossing compound for research. Numerous preclinical and clinical studies also displayed the promising potential of OA against cancer, cardiovascular diseases, inflammation, neurological disorders, rheumatoid arthritis, osteoarthritis, etc. Therefore, the current review focuses on delineating the role of OA in combating different chronic diseases and highlighting the intrinsic molecular mechanisms of its action.

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131. The constitution of oroxylin-A, a yellow colouring matter from the root-bark of Oroxylum indicum, vent

Cited by 16 publications

References 0 publications

STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma

STAT3 targeting by polyphenols: Novel therapeutic strategy for melanoma

Anti-Allergic Effect of Oroxylin A from Oroxylum indicum Using in vivo and in vitro Experiments

Oroxylin A: A Promising Flavonoid for Prevention and Treatment of Chronic Diseases

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