2012
DOI: 10.4012/dmj.2011-182
|View full text |Cite
|
Sign up to set email alerts
|

3-dimensional composite scaffolds consisting of apatite-PLGA-atelocollagen for bone tissue engineering

Abstract: We fabricated 3-dimensional scaffolds consisting of biodegradable poly(D, L-lactide-co-glycolic acid)(PLGA)(75/25) with hydroxyapatite particles containing atelocollagen (aAC). The aim of this study was to evaluate this new type of scaffold in regard to its basic properties and biocompatibility. Characterization of the obtained scaffolds was performed to know the porosity, shrinkage, diametral tensile strength, and biocompatibility. Composite scaffolds made of PLGA with hydroxyapatite particles containing atel… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
12
0

Year Published

2013
2013
2020
2020

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 15 publications
(12 citation statements)
references
References 23 publications
0
12
0
Order By: Relevance
“…Considering the strength of titanium, we used a PCL/PLGA/TCP blend, in which the role of the PLGA was to enhance membrane stiffness [17,18]. However, the acidic products generated during the degradation of PLGA have been reported to cause rapid swelling and inflammatory response in vivo, and PLGA, including membranes, have been reported to fail structurally because of their rapid degradation rates and inflammatory response [27,28,29,30,31]. Therefore, we decided to exclude PLGA, and focused on PCL/β-TCP membranes for GBR.…”
Section: Discussionmentioning
confidence: 99%
“…Considering the strength of titanium, we used a PCL/PLGA/TCP blend, in which the role of the PLGA was to enhance membrane stiffness [17,18]. However, the acidic products generated during the degradation of PLGA have been reported to cause rapid swelling and inflammatory response in vivo, and PLGA, including membranes, have been reported to fail structurally because of their rapid degradation rates and inflammatory response [27,28,29,30,31]. Therefore, we decided to exclude PLGA, and focused on PCL/β-TCP membranes for GBR.…”
Section: Discussionmentioning
confidence: 99%
“…Ciapetti et al described that the dissolution of HAp granules in PCL/HAp composite scaffold released Ca/P ion, influenced cells in the immediate vicinity, induced the redeposition of calcium phosphate, enhanced bone formation, and, moreover, corrected the release of acid from the polymer [203]. Takechi et al, using solvent casting/particulate leaching method, fabricated highly porous 3-dimensional scaffolds (PL-aAC) consisting of biodegradable poly(D,L-lactide-co-glycolic acid) (PLGA) with hydroxyapatite particles containing atelocollagen (aAC) [212]. According to results of examination of its basic properties and biocompatibility both in vitro and in vivo , PL-aAC scaffolds showed a greater strength and stability than PLGA scaffolds, and superior performance in terms of cell attachment and proliferation as compared with PLGA.…”
Section: Scaffolds For Cellular Bone Tissue Engineering (Bone Tissmentioning
confidence: 99%
“…These biomaterials must not only fill the space previously occupied by bone tissue, but also promote a specific biologic response (4). Membranes prevent proliferation of non-osteogenic cells in the defect, whereas scaffolds are used to provide support for slower bone cells to form a quality substitute tissue (4).…”
Section: Introductionmentioning
confidence: 99%
“…Collagen is one of the most used biomaterials for this purpose, due to its biocompatibility and bioactivity (4). The collagen matrix stimulates cellular migration, proliferation and infiltration, considered important properties for regenerative process (5).…”
Section: Introductionmentioning
confidence: 99%