Extractive reserves (RESEXs) are relevant areas that aim to allow the conservation of environmental resources and sustainable production practices of extractivism, agriculture, and livestock. In this study, we evaluated whether this aim is viable in the context of sustainability and conservation. Data were collected in the Alto Juruá, Rio Ouro Preto, and Rio Cajari RESEXs, via 384 questionnaires to investigate environmental, economic, social, and institutional issues in different communities. Here, we conclude that the failure of RESEXs in relation to conservation and development is correlated with a lack of institutional investment in innovations and technologies; low production from extractivism, agriculture, and livestock; lack of technical support; low production; and difficulties in markets for the commercialization of products.