A Novel Approaches on Ocular Drug Delivery System

Ramesh, Yerikala; Kothapalli, Chandrasekhar B.; Reddigari, Jayachandra Reddy Peddappi

doi:10.22270/jddt.v7i6.1512

Cited by 11 publications

(9 citation statements)

References 31 publications

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“… Vitreous Chamber The vitreous chamber is a tiny region in front of the eye that includes a watery, thinjelly-like fluid that is spread between the retina and the lens 13 .…”

Section:  Ciliary Musclementioning

confidence: 99%

In-Situ Ocular Gel Pharmaceutical Delivery System: A Recent Review

Kapila

Dev

Prasad

2021

J. Drug Delivery Ther.

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Ocular Drug Delivery has been a key challenge and attractive field for the pharmaceutical scientist due to peerless anatomy and physiology of eye. Glaucoma, dry eye syndrome, keratitis, endophthalmitis, trachoma, and conjunctivitis are just a few of the conditions that can affect the eye. In order to accomplish efficient ocular treatment within the eye, At the point of action, an appropriate supply of active substances must be given and sustained. Due to fast precorneal medication loss, traditional treatment has a low bioavailability. The bioavailability of a medicine is also influenced by static and dynamic barriers. To address the limitations of traditional treatment, significant efforts are being made to develop innovative medication systems for ocular delivery. When a drop is injected into the eye, it goes through a sol-gel transition and forms a cul-de-sac. The in-situ gel system, which comprises thermally triggered, pH triggered, and ion cross linking systems, is the subject of this review. It includes a step-by-step procedure for preparing the pH-triggered system as well as assessment parameters. Keywords: Conventional dosage form, Anatomy and physiology in eye, In-situ gel.

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“… Vitreous Chamber The vitreous chamber is a tiny region in front of the eye that includes a watery, thinjelly-like fluid that is spread between the retina and the lens 13 .…”

Section:  Ciliary Musclementioning

confidence: 99%

In-Situ Ocular Gel Pharmaceutical Delivery System: A Recent Review

Kapila

Dev

Prasad

2021

J. Drug Delivery Ther.

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“…Common barriers to the systemic delivery of ophthalmic drugs are blood-aqueous barrier and blood-retinal barrier (BRB) for the anterior segment and posterior segments of eye, respectively [14].…”

Section: Systemic Routementioning

confidence: 99%

Ocular Drug Delivery System: Challenges and Approaches

2020

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The ocular drug delivery deviates through a number of anatomical and physiological barriers, which have been a bottleneck for the ophthalmologists. The ocular barriers, static and dynamic, decrease the absorption of the therapeutic agents and the entry of the xenobiotics. Thus, a conventional ocular dosage form has various disadvantages of its use in ocular diseases. Hence, an ideal ocular delivery system has always been aimed, where the bioavailability of a drug is maintained for a longer period of time. The present review aims to focus on the drawbacks of the conventional ocular therapy and the advantages of designing novel delivery systems, with their certain specific advantages in ocular pharmacokinetics and the enhancement of bioavailability. These novel approaches emphasize on the benefits of various ocular drug delivery systems, like eye ointments, gels and use of viscosity enhancers, prodrugs, penetration enhancers, microparticles, liposomes, niosomes, ocular inserts, implants, intravitreal injections, nanoparticles, nanosuspension, microemulsion, dendrimers, in situ gels, iontophoresis and periocular injections. The compiled data presented in this review will act as a good information resource and reference point for further researches in the field of ocular drug delivery aiming non-invasive sustained release of drugs in the anterior and posterior segments of the eye.

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“…The dynamic of this research is evidenced by the number of publications that appear in scientific journals. Table 1 summarises the review papers that have been published in recent years [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Soft Contact Lenses as Drug Delivery Systems: A Review

Rykowska

Nowak

Nowak³

2021

Molecules

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This review describes the role of contact lenses as an innovative drug delivery system in treating eye diseases. Current ophthalmic drug delivery systems are inadequate, particularly eye drops, which allow about 95% of the active substance to be lost through tear drainage. According to the literature, many interdisciplinary studies have been carried out on the ability of contact lenses to increase the penetration of topical therapeutic agents. Contact lenses limit drug loss by releasing the medicine into two layers of tears on either side of the contact lens, eventually extending the time of contact with the ocular surface. Thanks to weighted soft contact lenses, a continuous release of the drug over an extended period is possible. This article reviewed the various techniques to deliver medications through contact lenses, examining their advantages and disadvantages. In addition, the potential of drug delivery systems based on contact lenses has been extensively studied.

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A Novel Approaches on Ocular Drug Delivery System

Cited by 11 publications

References 31 publications

In-Situ Ocular Gel Pharmaceutical Delivery System: A Recent Review

In-Situ Ocular Gel Pharmaceutical Delivery System: A Recent Review

Ocular Drug Delivery System: Challenges and Approaches

Soft Contact Lenses as Drug Delivery Systems: A Review

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