A novel biosensor based on boronic acid functionalized metal-organic frameworks for the determination of hydrogen peroxide released from living cells

Dai, Hongxia; Lü, Wenhui; Zuo, Xianwei; Zhu, Qian; Pan, Congjie; Niu, Xiaoying; Liu, Juanjuan; Chen, Hongli; Chen, Xingguo

doi:10.1016/j.bios.2017.04.021

Cited by 111 publications

(46 citation statements)

References 44 publications

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“…It can specifically accumulate in tumor tissues and has intense absorptions in the phototherapeutic wavelength window (650–900 nm) for better tissue penetration depth as well as high ROSs generation efficiency. 179–181 In order to achieve excellent photodynamic treatment and target imaging of tumor cells, many PDT agents including semiconductor QDs, 182 fullerene C 60 , 183 metal NPs, 184 and TiO 2 185 have been combined with lanthanide-doped NPs for constructing the image-guided tumor-targeting therapeutic agents. 186 A new type of “nanodumbbell” NIR NaYF 4 @lipid@polymersome nanoparticle with RE NPs core and hydrophilic polymersome lipid shell was designed in Wang’s group.…”

Section: Tumor Therapymentioning

confidence: 99%

Application of rare earth-doped nanoparticles in biological imaging and tumor treatment

et al. 2020

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Rare earth-doped nanoparticles have been widely used in disease diagnosis, drug delivery, tumor therapy, and bioimaging. Among various bioimaging methods, the fluorescence imaging technology based on the rare earth-doped nanoparticles can visually display the cell activity and lesion evolution in living animals, which is a powerful tool in biological technology and has being widely applied in medical and biological fields. Especially in the band of near infrared (700–1700 nm), the emissions show the characteristics of deep penetration due to low absorption, low photon scattering, and low autofluorescence interference. Furthermore, the rare earth-doped nanoparticles can be endowed with the water solubility, biocompatibility, drug-loading ability, and the targeting ability for different tumors by surface functionalization. This confirms its potential in the cancer diagnosis and treatment. In this review, we summarized the recent progress in the application of rare earth-doped nanoparticles in the field of bioimaging and tumor treatment. The luminescent mechanism, properties, and structure design were also discussed.

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Section: Tumor Therapymentioning

confidence: 99%

Application of rare earth-doped nanoparticles in biological imaging and tumor treatment

et al. 2020

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“…[54][55][56] They have also been widely applied in diverse biomedical fields, for example, drug/gene/protein loading, [57][58][59] tumor therapies, [60,61] bacterial disinfection, [62] ROS scavenging and tissue regeneration, [63,64] and biosensors. [65] In particular, the MOF-engineered Enz-Cats facilitate accurate discernment and characterization of catalytic sites at the molecular/atomic scale, which contributes to clarifying the catalytic mechanisms that afford great perception into the construction of superior Enz-Cats in various physiological environments. [66] This progress report highlights and comments on recent advances in designing MOF-engineered Enz-Cats, including the preparation methods, composite construction, structural characterizations, and biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Metal–Organic‐Framework‐Engineered Enzyme‐Mimetic Catalysts

et al. 2020

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high sensitivity to surroundings, and difficulties in recycling and reuse, limit their further applications. Thus, this situation has promoted the rapid exploration and development of various artificial enzyme mimics, including fullerenes, porphyrins, biomolecules, metal complexes, polymers, and functional nanomaterials. [3-6] Among these enzyme-mimetic catalysts (Enz-Cats, also defined as nanozymes in some systems), [4,5,7,8] alkaline metals, transition metals, and lanthanoid components [9-11] have been devoted to extending their applications in the fields of disease diagnosis, [12,13] wound disinfection, [14] and tumor treatments. [15-17] In particular, synthesizing metal-based nanomaterials to engineer Enz-Cats by precisely modulating their catalytic metal centers, sizes, structures, porosities, and compositions has been a long-standing objective, which provides tremendous opportunities to explore highly efficient Enz-Cats and reveal the essential catalytic mechanisms. [18-21] Although some developed Enz-Cats have exhibited efficient in vitro activities, the catalytic performances and selectivity in diverse physiological environments are still vital considerations during the exploration of their further application in biomedical areas. [22-24] Furthermore, the inherent physicochemical characteristics of these Enz-Cats may yield multiple catalytic reactions, such as generating or scavenging reactive oxygen species (ROS) under internal microenvironments Nanomaterial-based enzyme-mimetic catalysts (Enz-Cats) have received considerable attention because of their optimized and enhanced catalytic performances and selectivities in diverse physiological environments compared with natural enzymes. Recently, owing to their molecular/atomic-level catalytic centers, high porosity, large surface area, high loading capacity, and homogeneous structure, metal-organic frameworks (MOFs) have emerged as one of the most promising materials in engineering Enz-Cats. Here, the recent advances in the design of MOF-engineered Enz-Cats, including their preparation methods, composite constructions, structural characterizations, and biomedical applications, are highlighted and commented upon. In particular, the performance, selectivities, essential mechanisms, and potential structure-property relations of these MOF-engineered Enz-Cats in accelerating catalytic reactions are discussed. Some potential biomedical applications of these MOF-engineered Enz-Cats are also breifly proposed. These applications include, for example, tumor therapies, bacterial disinfection, tissue regeneration, and biosensors. Finally, the future opportunities and challenges in emerging research frontiers are thoroughly discussed. Thereby, potential pathways and perspectives for designing future state-of-the-art Enz-Cats in biomedical sciences are offered.

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“…During the past decade, various analytical methods, including spectrophotometry [12,13], fluorescence analysis [14,15], and electrochemical sensors [16,17], have been developed for detection of H 2 O 2 . Among them, electrochemical sensors received significant attention due to many practical advantages, including high sensitivity, rapid response time, portability, low cost, and ease of operation [17][18][19]. In particular, an amperometric sensor can be very useful in biological applications because of its ability to provide reliable responses in real time, even in complex biological systems.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of H2O2 Released from Prostate Cancer Cells Using Pt Nanoparticle-Decorated rGO–CNT Nanocomposite-Modified Screen-Printed Carbon Electrodes

Lee

Kim

et al. 2020

Chemosensors

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In this study, we fabricated platinum nanoparticles (PtNP)-decorated, porous reduced graphene oxide (rGO)–carbon nanotube (CNT) nanocomposites on a PtNP-deposited screen-printed carbon electrode (PtNP/rGO–CNT/PtNP/SPCE) for detection of hydrogen peroxide (H2O2), which is released from prostate cancer cells LNCaP. The PtNP/rGO–CNT/PtNP/SPCE was fabricated by a simple electrochemical deposition and co-reduction method. In addition, the amperometric response of the PtNP/rGO–CNT/PtNP/SPCE electrode was evaluated through consecutive additions of H2O2 at an applied potential of 0.2 V (vs. Ag pseudo-reference electrode). As a result, the prepared PtNP/rGO–CNT/PtNP/SPCE showed good electrocatalytic activity toward H2O2 compared to bare SPCE, rGO–CNT/SPCE, PtNP/SPCE, and rGO–CNT/PtNP/SPCE. In addition, the PtNP/rGO–CNT/PtNP/SPCE electrode exhibited a sensitivity of 206 μA mM−1·cm−2 to H2O2 in a linear range of 25 to 1000 μM (R2 = 0.99). Moreover, the PtNP/rGO–CNT/PtNP/SPCE electrode was less sensitive to common interfering substances, such as ascorbic acid, uric acid, and glucose than H2O2. Finally, real-time monitoring of H2O2 released from LNCaP cells was successfully performed by this electrode. Therefore, we expect that the PtNP/rGO–CNT/PtNP/SPCE can be utilized as a promising electrochemical sensor for practical nonenzymatic detection of H2O2 in live cells or clinical analysis.

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A novel biosensor based on boronic acid functionalized metal-organic frameworks for the determination of hydrogen peroxide released from living cells

Cited by 111 publications

References 44 publications

Application of rare earth-doped nanoparticles in biological imaging and tumor treatment

Application of rare earth-doped nanoparticles in biological imaging and tumor treatment

Metal–Organic‐Framework‐Engineered Enzyme‐Mimetic Catalysts

Electrochemical Detection of H2O2 Released from Prostate Cancer Cells Using Pt Nanoparticle-Decorated rGO–CNT Nanocomposite-Modified Screen-Printed Carbon Electrodes

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