A novel reactive oxygen species-responsive polymeric micelle for near-infrared light-triggered drug release in cancer cells

Chu, Yuehuan; Wu, Xi; Wu, Yundi; Liu, Lixin; Chen, Yongming

doi:10.1016/j.jconrel.2017.03.359

Cited by 3 publications

(2 citation statements)

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“…The second major function of ROS is to induce the structural change of carriers. With such an approach, Chu et al developed ICG-loaded, ROS-responsive polymeric micelles for NIR-triggered drug release. ICG was encapsulated into the micelles self-assembled from poly(ethylene glycol)- b -poly(2-(methylthio)ethyl methacrylate) (PEG- b -PMTEMA).…”

Section: Indirect Photoresponsive Delivery Systemsmentioning

confidence: 99%

“…The second major function of ROS is to induce the structural change of carriers. With such an approach, Chu et al 99 developed ICG-loaded, ROS-responsive polymeric micelles for ROS can also function to weaken the coordination interaction between different components. Li et al 101 designed an ROS-responsive vector composed of tellurium-containing BCP (PEG-PUTe-PEG) loaded with cisplatin (CDDP) and ICG.…”

Section: Indirect Photoresponsive Delivery Systemsmentioning

confidence: 99%

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Photoresponsive Drug/Gene Delivery Systems

et al. 2018

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Light as an external stimulus can be precisely manipulated in terms of irradiation time, site, wavelength, and density. As such, photoresponsive drug/gene delivery systems have been increasingly pursued and utilized for the spatiotemporal control of drug/gene delivery to enhance their therapeutic efficacy and safety. In this review, we summarized the recent research progress on photoresponsive drug/gene delivery, and two major categories of delivery systems were discussed. The first category is the direct responsive systems that experience photoreactions on the vehicle or drug themselves, and different materials as well as chemical structures responsive to UV, visible, and NIR light are summarized. The second category is the indirect responsive systems that require a light-generated mediator signal, such as heat, ROS, hypoxia, and gas molecules, to cascadingly trigger the structural transformation. The future outlook and challenges are also discussed at the end.

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Section: Indirect Photoresponsive Delivery Systemsmentioning

confidence: 99%

Section: Indirect Photoresponsive Delivery Systemsmentioning

confidence: 99%