A review on potentiality of medicinal plants as the source of new contraceptive principles

Unny, R.; Chauhan, Akshansha; Joshi, Yogesh; Dobhal, M. P.; Gupta, Radhey S.

doi:10.1078/094471103321659997

Cited by 32 publications

(32 citation statements)

References 163 publications

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“…Esta planta se halla por lo general en los cafetales, dándole sombra a los arbustos, de donde se deriva su nombre. Tiene varios usos en la medicina tradicional, entre ellos el de inhibidor espermático 29 demostró que el extracto metanólico de las vainas de la planta administrado durante 60 días a machos de ratas albinas en dosis de 50, 100 y 200 mg/kg/día, suprime la espermatogénesis y altera la estructura y la actividad tanto de las células de Sertoli como de las células de Leydig en una manera dosis-dependiente 30 . En un estudio más reciente, mediante la evaluación histológica de testículos de ratas a las cuales se les administró por vía oral saponinas aisladas de la corteza de la planta en dosis de 50 mg/kg/día durante 60 días, se observó una vacuolización en los espermatocitos primarios, una reducción de los diámetros de los túbulos seminíferos y un incremento del espacio intertubular en comparación con las ratas control.…”

Section: Albizia Lebbeckunclassified

“…Con estos resultados se concluyó que la planta tenía un efecto negativo en la fertilidad y que éste tal vez se debía a las alteraciones inducidas por las saponinas en las funciones de las células somáticas testiculares 31 . Otra planta colombiana perteneciente al mismo género y con actividad espermicida es la Albizia procera (citado en 29 ).…”

Section: Albizia Lebbeckunclassified

“…En Colombia está aprobado su uso como antinflamatorio y cicatrizante. Posee carotenoides, flavonoides, taninos, saponinas y lactonas terpénicas, entre otras 32 y el aceite esencial obtenido de sus flores es considerado un fungicida eficaz en infecciones vaginales (citado en 32 ) además se le atribuye efecto espermicida (citado en 29 ).…”

Section: Calendula Officinalisunclassified

“…Se le atribuyen propiedades diuréticas y sudoríficas además de ser purgante en dosis elevadas; adicionalmente, se ha observado que presenta actividad espermicida (citado en 29 ).…”

Section: Eupatorium Brevipesunclassified

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Nuevas opciones en anticoncepción: posible uso espermicida de plantas colombianas

et al. 2007

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RESUMEN NUEVAS OPCIONES EN ANTICONCEPCIÓN: POSIBLE USO ESPERMICIDADE PLANTAS COLOMBIANAS En la actualidad existe una creciente preocupación por la salud sexual y reproductiva de los adolescentes, ya que pese a la existencia de diferentes métodos anticonceptivos el número de embarazos no deseados va en aumento. Entre los productos disponibles se encuentran los espermicidas, que son un método totalmente controlado por la mujer y con características ventajosas respecto a los anticonceptivos de uso continuo, pero que tiene como desventaja la provocación de irritaciones en el epitelio vaginal debido a un efecto tensoactivo sobre la membrana celular, lo que podría facilitar la transmisión de infecciones. En la búsqueda de nuevas alternativas, se ha encontrado que una amplia variedad de plantas tiene actividad espermicida, lo que permite pensar en una propuesta interesante para un anticonceptivo de origen vegetal, que constituya una herramienta clave en la prevención de embarazos no deseados e impacte en un grupo poblacional especialmente vulnerable, como lo son las adolescentes y las mujeres jóvenes.Palabras clave: Espermatozoide. Espermicida. Planificación. Anticonceptivos. Extractos vegetales. ABSTRACT COLOMBIAN PLANTS WITH SPERMICIDAL ACTIVITY, NEW OPTIONS IN ANTICONCEPTION:BRIEF REVIEW Currently there exists increasing preoccupation concerning sexual and reproductive health among teenagers; in spite of the availability of different contraceptive methods, the number of undesired pregnancies is steadily increasing. Among the products presently available for birth control, spermicides are a means that can be totally controlled by the woman and are very reliable compared to other contraceptives in common use. However, they cause irritation in the vaginal epithelium due to their tensoactive effect on cellular membranes which might enhance the risk of acquiring sexually transmissible diseases. In searching for new alternatives, it was observed that a wide variety of plants have spermicidal activity. Hence it is interesting to consider potential contraceptives of vegetable origin, as they may constitute a key tool to prevent undesired pregnancies in general, and in particular in vulnerable groups such as teenagers and young women.

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Section: Albizia Lebbeckunclassified

Section: Calendula Officinalisunclassified

“…Se le atribuyen propiedades diuréticas y sudoríficas además de ser purgante en dosis elevadas; adicionalmente, se ha observado que presenta actividad espermicida (citado en 29 ).…”

Section: Eupatorium Brevipesunclassified

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Nuevas opciones en anticoncepción: posible uso espermicida de plantas colombianas

et al. 2007

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“…The plant, however, never reached commercial status in view of the lower sapogenin content compared with the existing commercial source, Dioscorea species. Nevertheless, interest in this potential aspect of the plant continues [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Variability in the Content of 25α- and 25β-Steroidal Sapogenins among Thirty Morphologically Different Sudanese Seed Accessions of Fenugreek

Osman¹,

Elhussein²,

Albalawi³

2014

JLS

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Abstract:Seeds of Fenugreek (Trigonellafoenum-graecum L.), an international spice commodity, are much consumed in Sudan as a food, for flavoring and as a folk-remedy for several ailments, together with local beliefs in nutraceutical benefits. The authors have noted an immense variability in colour and other morphological characters of Fenugreek seeds offered in local Sudanese markets and wondered whether this variability is extended to their chemical composition. Steroidal sapogenins are important chemical constituents of Fenugreek seeds in view of their potential as precursors for the commercial synthesis of steroid drugs and their continually revealed beneficial biological activities. In this study, thirty Sudanese Fenugreek seed accessions collected from different geographical regions in Sudan were analyzed for their 25α-, 25β-and total sapogenin content using a simple and specific infra-red spectroscopic method. The seed accessions exhibited much morphological variability particularly in outer seed coat color and size. Preparative TLC followed by gravimetric analysis showed that steroidal sapogenins, mostly diosgenin and yamogenin, represented more than 70% of the steroids of Fenugreek seeds. Infra-red spectroscopic analysis showed that total 25α-sapogenins (calculated as diosgenin) varied from 0.65% to 1.68%. Total 25β-sapogenin (calculated as yamogenin) varied from 0.38% to 2.03%. The content of total sapogenins (α + β epimeric forms) varied between 1.24% and 3.0% of the oven-dry weight of seeds. β-sapogenins (mostly yamogenin) were dominant over α-sapogenins (diosgenin) in most Sudanese Fenugreek seed accessions.

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Fertility control of rodent pests: a review of the inhibitory effects of plant extracts on ovarian function

Tran

Hinds

2012

Pest Management Science

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Protection of plant extracts to prevent their degradation before uptake in the gastrointestinal tract could enhance short-term efficacy but would not enhance the longevity of their effects. Identification and further testing of the specific chemicals responsible for reproductive effects would be beneficial. The adoption of a standard protocol for treatment and assessment of the inhibitory effects of potential control agents on reproductive function in rodents is essential. Treatment with higher concentrations of extracts in conjunction with other extracts or with other chemosterilants could have potential complementary effects and lead to more rapid and permanent changes in ovarian function. An orally delivered agent(s) that causes major depletion of all follicle types, and particularly of non-regenerating primordial follicles, could be an ideal fertility control product and serve as an additional tool for population control of pest rodents.

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A review on potentiality of medicinal plants as the source of new contraceptive principles

Cited by 32 publications

References 163 publications

Nuevas opciones en anticoncepción: posible uso espermicida de plantas colombianas

Nuevas opciones en anticoncepción: posible uso espermicida de plantas colombianas

Variability in the Content of 25α- and 25β-Steroidal Sapogenins among Thirty Morphologically Different Sudanese Seed Accessions of Fenugreek

Fertility control of rodent pests: a review of the inhibitory effects of plant extracts on ovarian function

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