Aliphatic carboxylic acids as new modifiers for separation of 2,4-dinitrophenyl amino acids by micellar liquid chromatography

Boichenko, Alexander P.; Kulikov, A. Yu.; Loginova, Lidia P.; Iwashchenko, Anna L.

doi:10.1016/j.chroma.2007.05.012

Cited by 21 publications

(5 citation statements)

References 33 publications

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“…Phosphoric acid was used for pH adjustments. It is interesting to note that the two acids and the two corresponding alcohols have the same molar volumes ( Table 2) so mobile phases with equal modifier volume fractions have also equal molar concentrations [31]. …”

Section: Experimental Design and Selection Of Experimental Conditionsmentioning

confidence: 99%

“…The effect of alcohols on the properties of micellar solutions has been extensively studied for years due to usefulness of such systems in microemulsion formation [34]. However, only a limited number of works focused on the effects of short and middle chain carboxylic acids on the properties of micellar solutions [31,32,39,40].…”

Section: Additive Effects On Micellar Solutions Of Sdsmentioning

confidence: 99%

“…However, many candidate modifiers for micellar mobile phases have not been fully evaluated yet. Hence, aliphatic carboxylic acids must also be tested as potential modifiers of SDS micellar eluents [31].…”

Section: Introductionmentioning

confidence: 99%

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Aliphatic carboxylic acids and alcohols as efficiency and elution strength enhancers in micellar liquid chromatography

Boichenko

Berthod

2010

Journal of Chromatography A

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Section: Experimental Design and Selection Of Experimental Conditionsmentioning

confidence: 99%

Section: Additive Effects On Micellar Solutions Of Sdsmentioning

confidence: 99%

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Aliphatic carboxylic acids and alcohols as efficiency and elution strength enhancers in micellar liquid chromatography

Boichenko

Berthod

2010

Journal of Chromatography A

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“…8,9 Another important advantage of MLC is the decreasing of silanophilic interactions due to dynamic modification of the stationary phase by adsorption of surfactant monomers. [9][10][11] Recently, Kulikov and Galat 12 have shown that the chromatographic properties of reversed-phase columns are much more similar in the MLC mode than in the RP-HPLC mode. This results in robust separation of analyte mixtures using columns from different manufactures in the MLC mode.…”

Section: Introductionmentioning

confidence: 99%

Optimization of micellar LC conditions for separation of opium alkaloids and their determination in pharmaceutical preparations

2011

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Micellar liquid chromatography (MLC) has been developed for the analysis of opium alkaloids. The composition of micellar mobile phase for the separation of morphine, codeine, papaverine and noscapine have been optimized by a chemometric tool taking into account the efficiency and asymmetry of chromatographic peaks, resolution between each pair of peaks and total time of separation. The optimized mobile phase composition (0.10 M sodium dodecylsulfate (SDS), 5% (v/v) 1butanol; pH 2.5) allows to fully separate alkaloids within 15 min. The proposed MLC method was validated, compared with the RP-HPLC method and successfully applied for the analysis of the pharmaceutical preparation ''Omnopon, solution for injection''.

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“…The growing interest in micellar LC (MLC) has resulted in an exponentially increasing production of analytical applications during the past few years 1–5. MLC presents noticeable advantages over conventional LC in the aspects as far as high solubilization capability, direct injection of physiological fluids and unique separation selectivity are concerned.…”

Section: Introductionmentioning

confidence: 99%

Micellar and aqueous‐organic liquid chromatography using sub‐2 μm packings for fast separation of natural phenolic compounds

Cao

Cheng

2010

J of Separation Science

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The objective of the present work was to investigate the chromatographic behavior of natural phenolic compounds in micellar and aqueous-organic LC using a short column packed with 1.8 microm particles. Firstly, the effect of ACN and SDS on elution strength and selectivity was examined by isocratic submicellar (0-30% ACN/5% 1-butanol/1-6 mM SDS) and micellar (0-30% ACN/5% 1-butanol/40-60 mM SDS) systems. The varied concentrations of two modifiers in the mobile phases revealed different eluting power. Then, the application of organic modifier gradient was discussed in both submicellar and micellar LC using mobile phases of 4 mM SDS/5% 1-butanol or 50 mM SDS/5% 1-butanol containing ACN gradient from 0 to 30%, respectively. For micellar system, the separation was found to be better in gradient than isocratic elution. Additionally, the sensitivity of aqueous-organic LC was examined. The mobile phase was a mixture of ACN and water employing gradient elution at a flow rate of 0.5 mL/min, with analysis time below 9 min. It was found that separation efficiency was significantly better compared with micellar LC. Besides, the aqueous-organic LC has been applied to separation of various phenolic compounds in Yangwei granule or Radix Astragali samples.

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Aliphatic carboxylic acids as new modifiers for separation of 2,4-dinitrophenyl amino acids by micellar liquid chromatography

Cited by 21 publications

References 33 publications

Aliphatic carboxylic acids and alcohols as efficiency and elution strength enhancers in micellar liquid chromatography

Aliphatic carboxylic acids and alcohols as efficiency and elution strength enhancers in micellar liquid chromatography

Optimization of micellar LC conditions for separation of opium alkaloids and their determination in pharmaceutical preparations

Micellar and aqueous‐organic liquid chromatography using sub‐2 μm packings for fast separation of natural phenolic compounds

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