Antidiabetic Activity Test Using Amla Fruit (Phyllanthus Emblica L) Extract in Alloxan-Induced Balb/C Mice

Cahyaningrum, Putu Lakustini; Yuliari, Sang Ayu Made; Suta, Ida Bagus Putra

doi:10.20473/jvhs.v3.i2.2019.53-58

Cited by 7 publications

(5 citation statements)

References 4 publications

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“…The process of taking blood was carried out on the tail of each mouse to check blood glucose levels. After that, mice with blood glucose levels above 200 mg/dl were used in this study because mice were considered to have hyperglycemia [10].…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of the Extract of Celery (Apium Graveolens L) Against Calculations Glucose In Vivo as Antidiabetic Alternatives

Halid¹,

Mentari²,

Navisa³

et al. 2022

Proceedings of the First International Conference on Medical Technology (ICoMTech 2021)

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Diabetes Mellitus is a group of disorders characterized by increased blood glucose levels (hyperglycemia) and there may be a decrease in the ability to respond to insulin as well as a decrease in insulin formation by the pancreas. Celery plant is an herbal medicine with antidiabetic activity which is widely used because of its nature which is more suitable for the human body. The content found in celery leaves is flavonoids, terpenoids, alkaloids, and steroids. This study aims to determine whether celery leaf extract (Apium Graveolens L) can reduce blood glucose levels in male mice (Mus Musculus L) to determine the concentration of blood sugar levels which can reduce blood glucose levels in male mice (Mus Musculus L) and to analyzed the effect of celery leaf extract (Apium Graveolens L) on blood glucose levels in male mice (Mus Musculus L). The research method used was true experiment with pre test approach and post test only control group design. The results of the research on celery leaf extract (Apium Graveolens L) were proven to be able to reduce blood glucose levels in male mice (Mus Musculus L), which was the most effective in the P3 group with a dose of 177 mg/kgBW.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of the Extract of Celery (Apium Graveolens L) Against Calculations Glucose In Vivo as Antidiabetic Alternatives

Halid¹,

Mentari²,

Navisa³

et al. 2022

Proceedings of the First International Conference on Medical Technology (ICoMTech 2021)

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show abstract

“…Several studies reported that alloxan increased the concentration of cytosolic free calcium in pancreatic β cells as a result of several processes, including increased influx of calcium from the extracellular fluid, intracellular mobilization, and reduced calcium loss in the cytoplasm. The ability of alloxan to cause diabetes also depends on the induction pathway, dose, compounds, experimental animals and nutritional status (Cahyaningrum et al, 2019).…”

Section: Antidiabetic Test Using Aloksan Induction Methodsmentioning

confidence: 99%

The Effectiveness of Ethyl Acetate Extract of Sungkai Leaves (Peronema Canescens Jack.) Against Blood Glucose Levels in Alloxan-Induced Male Mice

Naldi¹,

Darwin²,

Zulfikri

2022

JAMRMHSS

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This research aims to test antidiabetic using alloxan induction on mice test animals. The type of research used is experimental, which includes sampling, sample determination. Extract preparation with ethyl acetate solvent, extract characteristics test and simplicia, extract and simplicia screening test. Antidiabetic testing was carried out using male mice as test animals. Screening tests for the presence of alkaloids, flavonoids, tannins, saponins, steroids, and glycosides for the anti-diabetic test of Sungkai leaves were carried out using alloxan induction in mice. With initial KGD 90-120 mg/dl. Extract concentrations were 100 mg/kg, 200 mg/kg and 300 mg/kg with negative control CMC Na 0.5% and metformin positive control 65 mg/kg. The most effective decrease in mice blood glucose on days 3, 7, 10 and 14 was at an extract concentration of 300 mg/kg bw with a decrease of 114 mg/dl. Based on the results of the ANOVA statistic Fcount 208.813> Ftable 2.87 so H0 is rejected, there is a significant decrease in blood sugar in mice. The results of the anti-diabetic test of the ethyl acetate extract of Sungkai leaves at a dose of 300 mg/kg body weight had an anti-diabetic effect on male mice after alloxan induced on the 14th day with an average of 114 being the most effective in reducing the male mice's KGD.

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“…Antioksidan alami dapat diperoleh dari tanaman malaka yang memiliki nama botani Phyllanthus emblica L. Kandungan flavonoid pada buah malaka dijadikan sebagai sumber antioksidan alami yang mampu mencegah penyakit yang umum muncul diusia tua yang diakibatkan penurunan fungsi sel dan efektif meningkatkan imunitas tubuh (Cahyaningrum et al, 2019;Gul et al, 2022;Huang et al, 2023;Kumar et al, 2022). Keseluruhan bagian tumbuhan malaka ini seperti biji, akar, ranting, bunga, daun dan buah diolah secara tradisional di negara India sebagai pengobatan yang kaya akan khasiat (Ahmad et al, 2021;Saini et al, 2022).…”

Section: Pendahuluanunclassified

FORMULASI DAN UJI ANTIOKSIDAN SEDIAAN FACE MIST DARI EKSTRAK ETANOL BUAH MALAKA (Phyllanthus emblica L.) SEBAGAI PELEMBAB WAJAH

Febriani,

Axyvia,

Salman

2024

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Antioksidan sebagai penangkal radikal bebas sangat diperlukan oleh tubuh. Sumber antioksidan bisa diperoleh secara alami dan mudah dijumpai di sekitar kita. Salah satu sumber antioksidan alami adalah buah malaka (Phyllanthus emblica L.) karena mengandung flavonoid. Buah malaka diformulasikan pada sediaan face mist karena mudah dibawa dan mudah diserap pada kulit. Penelitian ini menggunakan metode eksperimental dimana buah malak diaplikasikan sebagai zat aktif pada sediaan face mist. Adapun uji yang dilakukan terhadap sediaan face mist yaitu uji mutu fisik sediaan, kelembaban dan nilai aktivitas antioksidan. Hasil mutu fisik sediaan menunjukkan keberhasilan karena telah memenuhi persyaratan. Sediaan face mist stabil dalam suhu yang diaplikasikan, pH yang diperoleh sesuai dengan pH kulit yaitu 5,1 – 5,6 dan tidak menimbulkan efek kemerahan pada kulit. Viskositas, daya sebar dan waktu kering sediaan face mist sebesar 4.00 – 8.00 mPa.s, 5 – 7 cm dan 3:05 – 4:02 menit. Persen kelembaban tertinggi dimiliki oleh Formulasi 3 yaitu sebesar 25,01% dan nilai aktivitas antioksidan tertinggi dimiliki oleh Formulasi 2 yaitu sebesar 18,84 μg/mL.

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Antidiabetic Activity Test Using Amla Fruit (Phyllanthus Emblica L) Extract in Alloxan-Induced Balb/C Mice

Cited by 7 publications

References 4 publications

Effectiveness of the Extract of Celery (Apium Graveolens L) Against Calculations Glucose In Vivo as Antidiabetic Alternatives

Effectiveness of the Extract of Celery (Apium Graveolens L) Against Calculations Glucose In Vivo as Antidiabetic Alternatives

The Effectiveness of Ethyl Acetate Extract of Sungkai Leaves (Peronema Canescens Jack.) Against Blood Glucose Levels in Alloxan-Induced Male Mice

FORMULASI DAN UJI ANTIOKSIDAN SEDIAAN FACE MIST DARI EKSTRAK ETANOL BUAH MALAKA (Phyllanthus emblica L.) SEBAGAI PELEMBAB WAJAH

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