Antioxidant Activities and Melanogenesis Inhibitory Effects of Terminalia chebula in B16/F10 Melanoma Cells

Lee, Hyun Sun; Cho, Hye Jin; Lee, Kwang Won; Park, Sung Sun; Seo, Ho Chan; Suh, Hyung Joo

doi:10.3746/jfn.2010.15.3.213

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…본 로 측정하였다 [25]. 측정결과, 톳 에탄올 추출물은 100 μg/ml 의 농도에서 음성 대조군에 비해 통계적으로 유의하게 mushroom tyrosinase의 활성을 44% 억제하였다 (Fig.…”

Section: 서 론unclassified

Whitening Effect of Hizikia fusiformis Ethanol Extract and Its Fractions

Jeon¹,

Kim²,

Jang³

et al. 2012

Journal of Life Science

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Melanin synthesis is catalyzed by tyrosinase. To investigate the whitening effect of Hizikia fusiformis, fractions from ethanol extract of H. fusiformis were prepared by a systematic fractionation procedure with solvents such as methanol, hexane, butanol, and H2O. The ethanol extract and its fractions were then subjected to evaluate the inhibitory effects on the tyrosinase activity and melanin synthesis in murine B16F10 melanoma cells. The ethanol extract and aqueous fraction exhibited a whitening effect with no cytotoxicity. The ethanol extract showed the highest whitening effect among the samples. The inhibitory effect of 100 μg/ml of ethanol extract was higher than that of 10 μg/ml of arbutin, but it was lower than that of 10 μg/ml of kojic acid. Furthermore, the inhibitory effects of 100 μg/ml of methanol, hexane, butanol, and aqueous fractions were similar to those of 10 μg/ml of arbutin. The antioxidant activities were examined by comparing the results with that of ascorbic acid as a positive control. The ethanol extract and aqueous fraction showed relatively higher DPPH radical-scavenging activities compared with the other samples. Furthermore, 500 μg/ml of ethanol extract and aqueous fraction diminished LPS-induced iNOS expression to 82 and 80%, respectively. These results suggest that ethanol extract and aqueous fraction of H. fusiformis could be used as cosmetic ingredients for whitening and skin protection effects.

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Section: 서 론unclassified

Whitening Effect of Hizikia fusiformis Ethanol Extract and Its Fractions

Jeon¹,

Kim²,

Jang³

et al. 2012

Journal of Life Science

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“…In humans, solar ultraviolet (UV) radiation, oxidative stress, chronic inflammation, and the excessive release of a-melanocytestimulating hormone (a-MSH) can trigger melanin biosynthesis and lead to hyperpigmentation (Jeong et al, 2009;Kim and Yokozawa, 2009;Lee et al, 2010a). Common manifestations of skin hyperpigmentation include freckles, melasma, solar lentigines, age spots, and post-inflammatory hyperpigmentation, all of which can be serious aesthetic concerns.…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents derived from Artocarpus xanthocarpus as inhibitors of melanin biosynthesis

Jin

Lin

et al. 2015

Phytochemistry

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“…활성은 mushroom tyrosinase를 효소원으로 하여 기질인 L-DOPA와의 반응으로 생성된 L-dopaquinone의 흡광도를 측정하였다 [22]. 측정 결과, sample 1~4 모두가 100 μg/mL 의 농도에서는 음성 대조군에 비해 각각 16%, 16%, 27%, 16%의 효소활성을 유의적으로 억제하였고, sample 3의 경우 는 10 μg/mL의 농도에서도 음성 대조군에 비해 16%의 효소 활성을 유의적으로 억제하였다 (Fig.…”

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Purification of Peat Moss Extract Using a Supercritical CO<sub> 2</sub> and Verification of Its Biological Activities

김미향¹,

전명제²,

박미라³

et al. 2011

KSBB Journal

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1) In this study, the canadian peat moss extract was purified by a supercritical CO2 using three different conditions and assessed its biological activities. Peat moss was extracted by acid-alkaline extraction method (sample 1) and purified by a supercritical CO2 at 40℃ under pressure of 100 bar (sample 2), 120 bar (sample 3) or 150 bar (sample 4). We evaluated the antioxidant activities of the samples by 1,1diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging, Fe 2+ / ascorbate (FTC) and 2-thiobarbituric acid (TBA) methods. The antioxidant activities were examined by comparing the results with that of ascorbic acid as a positive control. Sample 3 showed relatively higher DPPH radical-scavenging activities than other samples. The antioxidant activity by FIC method exhibited similar results as the DPPH radicalscavenging activities. On the other hand, sample 2 showed higher antioxidant activity measured by TBA method of all. The whitening effects of the samples were examined using mushroom tyrosinase and B16F10 melanoma cells. Sample 3

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Antioxidant Activities and Melanogenesis Inhibitory Effects of Terminalia chebula in B16/F10 Melanoma Cells

Cited by 4 publications

References 30 publications

Whitening Effect of Hizikia fusiformis Ethanol Extract and Its Fractions

Whitening Effect of Hizikia fusiformis Ethanol Extract and Its Fractions

Chemical constituents derived from Artocarpus xanthocarpus as inhibitors of melanin biosynthesis

Purification of Peat Moss Extract Using a Supercritical CO<sub> 2</sub> and Verification of Its Biological Activities

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