Antioxidant activity of bioactive compound produced by endophytic fungi isolated from endemic plant of South Kalimantan Mangifera casturi Kosterm

Nuraini, Fatia Rizki; Setyaningsih, Ratna; Susilowati, Ari

doi:10.1063/1.5115751

Cited by 15 publications

(13 citation statements)

References 32 publications

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“…Therefore, using EtOAc in this study to extract the antioxidant compounds is the best way to evaluate the antioxidant activities of the endophytic fungal strains. DPPH free radical scavenging assay is the frequently used method in evaluation of antioxidant activities because it is simple, quick, low-cost, considered to be the most accurate method and not affected by metals and enzymes (Gunasekaran et al 2017;Nuraini et al 2019). Figure 1b presented that all fungal crude extracts exhibited significant antioxidant activities as compared to the standard (ascorbic acid) and they tended to increase their activities with increasing concentration.…”

Section: Antioxidant Activitymentioning

confidence: 97%

“…In this context, Chaetomium atrobrunneum has been reported to produce potent antifungal fuscoatroside and chaetoatrosin A (Hwang et al 2000;Kobayashi et al 2005). Moreover, Chaetomium gracile and Chaetomium brasiliense also described as an antibacterial producer (Oh et al 1998;Bai et al 2015). Furthermore, antibiotics Chaetochalsin A and Chaetomin were produced by C. brasiliense and Chaetomium cochliodes respectively (Waksman and Bugie 1944;Oh et al 1998).…”

Section: Antimicrobial Activity Of Endophytic Fungimentioning

confidence: 99%

“…Moreover, Chaetomium gracile and Chaetomium brasiliense also described as an antibacterial producer (Oh et al 1998;Bai et al 2015). Furthermore, antibiotics Chaetochalsin A and Chaetomin were produced by C. brasiliense and Chaetomium cochliodes respectively (Waksman and Bugie 1944;Oh et al 1998).…”

Section: Antimicrobial Activity Of Endophytic Fungimentioning

confidence: 99%

“…1b). Nuraini et al (2019) suggested that the phenolic contents in endophytic fungal cultures extracts were the major antioxidant constituents. In this context, the results showed a strong significant relationship between total phenolics and antioxidant activity (correlation coefficient 'r' = 0Á8674, Fig.…”

Section: Antioxidant Activitymentioning

confidence: 99%

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Fungal endophytes from leaves of Avicennia marina growing in semi‐arid environment as a promising source for bioactive compounds

Khalil

Abdelaziz

Khaleil

et al. 2020

Lett Appl Microbiol

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Significance and Impact of the Study: This work is the first report for isolating, characterizing and identifying the culturable fungi that colonize leaves of Avicennia marina residing in harsh and heavy metal-enriched habitat at Yanbu industrial city in an attempt to evaluate their activity against human pathogenic microbes and antioxidant potential with measuring the toxicity of its crude extracts. A further objective was to assess the preliminary qualitative phytochemical screening of secondary metabolites, total phenolics quantitatively and detecting the bioactive compounds using GC-MS. This study might be offering a novel species with valuable bioactive metabolites, which provide a new source for drug discovery.

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Section: Antioxidant Activitymentioning

confidence: 97%

Section: Antimicrobial Activity Of Endophytic Fungimentioning

confidence: 99%

Section: Antimicrobial Activity Of Endophytic Fungimentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

See 2 more Smart Citations

Fungal endophytes from leaves of Avicennia marina growing in semi‐arid environment as a promising source for bioactive compounds

Khalil

Abdelaziz

Khaleil

et al. 2020

Lett Appl Microbiol

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“…AKF1 and DK7 exhibited antioxidant ability with an IC50 of 142.96μg/mL and 145.01μg/mL respectively. GC-MS analysis confirmed that the most dynamic compound isolated from AKF1 and DK7 was dihydropyran and 4H-Pyran-4-one,5-hydroxy-2-(hydroxymethyl-(CAS) Kojic acid, respectively [104].…”

Section: Antioxidant Compounds Produced By Endophytic Fungimentioning

confidence: 87%

Microorganisms: A Potential Source of Bioactive molecules for Antioxidants and Antimicrobial Applications

Rani¹,

Saini²,

Bast³

et al. 2021

Preprint

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Oxidative stress is an elevated intracellular level of free oxygen radicals that cause lipid peroxidation, protein denaturation, DNA hydroxylation, and apoptosis, ultimately negotiating cells viability. Antioxidants can scavenge such free radicals, thus reducing the oxidative stress and eventually prevent cellular damage. Medicinal plants, fruits, and spices remain the prioritized sources of antioxidants and antimicrobial properties since the time immemorial, but in contrast to plants, microorganisms can be grown at a faster rate under controlled conditions. They are non-toxic, non-carcinogenic, and biodegradable as compared to synthetic antioxidants. Microorganisms including actinomycetes, archaea, bacteria, protozoa, yeast, and fungi are auspicious source of vital bioactive compounds. The list comprises ample of bioactive components from microorganisms. One of them is bacteriocins, which are ribosomally synthesized antimicrobial peptides product of Eurotium sp., Streptomyces parvulus, S. thermophiles, Lactococcus lactis, etc. It has a great potential as next-generation antibiotics targeting the multiple-drug resistant pathogens. Pneumocandins are antifungal lipohexapeptides derived from the fungus Glarea lozoyensis, and inhibit 1,3-β-glucan synthase of the fungal cell wall and act as a precursor for the synthesis of caspofungin. It is widely used against invasive fungal infections and has been recently approved by the FDA. Taxol (paclitaxel), a chemotherapeutic drug derived from the bark of Taxus brevifolia can also be produced by endophytic fungi Taxomyces andreanae and Nodulisporium sylviforme. It is known to inhibit several fungi such as Pythium, Aphanomyces and Phytophthora. Hispidin and its derivate isolated from P. hispidus, reduce inducible nitric oxide synthase (iNOS) expression, obstruct the transcriptional activity of NF-κB, and also decrease the production of reactive oxygen species (ROS) in macrophages. Astaxanthin, known as an “aquatic” carotenoid produced by H. pluvialis, also has excellent ROS quenching activity. This study mainly focuses on fascinating antioxidant and antimicrobial compounds that have been scarcely investigated in microorganisms and discuss the promise and challenges of microorganisms as providers of health benefits.

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Untapped Bioactive Compounds from Endophytic Fungi with Potential Antioxidant Activity

Bhaskar,

Jain,

Srivastava

2024

Fungal Biology

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Antioxidant activity of bioactive compound produced by endophytic fungi isolated from endemic plant of South Kalimantan Mangifera casturi Kosterm

Cited by 15 publications

References 32 publications

Fungal endophytes from leaves of Avicennia marina growing in semi‐arid environment as a promising source for bioactive compounds

Fungal endophytes from leaves of Avicennia marina growing in semi‐arid environment as a promising source for bioactive compounds

Microorganisms: A Potential Source of Bioactive molecules for Antioxidants and Antimicrobial Applications

Untapped Bioactive Compounds from Endophytic Fungi with Potential Antioxidant Activity

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