Association between Alzheimer's disease and risk of cancer: A retrospective cohort study in Shanghai, China

Ren, Rong; Huang, Qiang; Xu, Gang; Gu, Kai; Dammer, Eric B.; Wang, Chunfang; Xie, Xinyi; Chen, Wen; Shao, Zhiyong; Chen, Shengdi; Wang, Gang

doi:10.1002/alz.12436

Cited by 15 publications

(17 citation statements)

References 55 publications

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“…Interestingly, a pilot study in Shanghai using hospital-based samples reported a similar survival trend of patients with AD compared with that of the general population. Poor cognitive status and comorbid diabetes had a negative impact on the survival of patients with AD,4 and a noteworthy association between AD and specific types of cancer was observed in China 16…”

Section: Data Source and Analysismentioning

confidence: 97%

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The China Alzheimer Report 2022

et al. 2022

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China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated, especially Alzheimer’s disease (AD) and related dementias (ADRD). AD’s incidence rate, morbidity, and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals, families and society. The ‘Healthy China Action’ plan of 2019–2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD. This report describes related epidemiological trends, evaluates the economic burden of the disease, outlines current clinical diagnosis and treatment status and delineates existing available public health resources. More specifically, it examines the public health impact of ADRD, including prevalence, mortality, costs, usage of care, and the overall effect on caregivers and society. In addition, this special report presents technical guidance and supports for the prevention and treatment of AD, provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation.

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Section: Data Source and Analysismentioning

confidence: 97%

“…Poor cognitive status and comorbid diabetes had a negative impact on the survival of patients with AD, 4 and a noteworthy association between AD and specific types of cancer was observed in China. 16 Ranking changes of ADRD in China from 1990 to 2019…”

Section: Epidemiology and Disease Burden Of Adrd In Chinamentioning

confidence: 99%

The China Alzheimer Report 2022

et al. 2022

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“…Moreover, the time course from the early stage to the late stage can be over 10 years 10 . An inverse relationship between AD and cancer has been well‐established; that is, older people with AD had a lower cancer risk, and vice versa, which was reported by several epidemiological studies 11–16 . The representative work by Phillip P. Wolf from the heart center showed a 60% decreased cancer rate (including brain tumors) from AD patients 11 .…”

Section: Introductionmentioning

confidence: 92%

Oligomer‐Aβ42 suppress glioma progression via potentiating phagocytosis of microglia

Lu,

Wang,

et al. 2023

CNS Neurosci Ther

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AimsGlioma is characterized by an immunosuppressed environment and a poor prognosis. The accumulation of Amyloid β (Aβ) leads to an active environment during the early stages of Alzheimer's disease (AD). Aβ is also present in glioma tissues; however, the biological and translational implications of Aβ in glioma are elusive.MethodsImmunohistochemical (IHC) staining, Kaplan–Meier (KM) survival analysis and Cox regression analysis on a cohort of 79 patients from our institution were performed to investigate the association between Aβ and the malignancy of glioma. Subsequently, the potential of oligomer‐Aβ42 (OAβ42) to inhibit glioma growth was investigated in vivo and in vitro. Immunofluorescence staining and phagocytosis assays were performed to evaluate the activation of microglia. Finally, RNA‐seq was utilized to identify the predominant signaling involved in this process and in vitro studies were performed to validate them.ResultsA positive correlation between Aβ and a favorable prognosis was observed in glioma. Furthermore, OAβ42 suppressed glioma growth by enhancing the phagocytic activity of microglia. Insulin‐like growth factor 1 (IGF‐1) secreted by OAβ42‐activated microglia was essential in the engulfment process.ConclusionOur study proved an anti‐glioma effect of Aβ, and microglia could serve as a cellular target for treating glioma with OAβ42.

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“…Until now, many researchers have investigated the association between AD and LC from the perspective of epidemiology [5][6][7][8][9][10][11][12][13] and genomics [14][15][16][17][18] . Some retrospective studies identi ed an inverse association between these two diseases 5-8,10−12 ; however, a prospective cohort study 13 did not support this conclusion.…”

Section: Introductionmentioning

confidence: 99%

Denoising autoencoder-based bulk and single-cell RNA-sequencing data analyses reveal a comorbidity relationship between Alzheimer’s disease and lung cancer

Li,

Tang,

Gao

et al. 2024

Preprint

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Numerous investigators have studied the correlation between Alzheimer’s disease (AD) and lung cancer (LC), yet a precise comprehension of their interconnection remains elusive. Prior studies have demonstrated the efficacy of certain targeted therapies for controlling ferroptosis in treating AD and LC. Moreover, ferroptosis plays a role in immune regulation. Therefore, this study aims to investigate the association between AD and LC in terms of ferroptosis and particularly its relevance to immune function. Firstly, bulk RNA sequencing data of AD and LC patients were employed to construct a denoising autoencoder (DAE) model that extracted a representation of ferroptosis-related genes. The representation scores were then utilized to conduct an in-depth investigation of the relationship between the two diseases. Furthermore, as immune function plays a pivotal role in AD and LC, we assessed the association of immune function between two diseases by isolating immune-related from Single-cell RNA sequencing (scRNA-seq) data and constructing a DAE model. Using a DAE model based on bulk RNA and scRNA-seq data, the comorbidity relationship between AD and LC in the context of ferroptosis was identified. Furthermore, we found that immune cells affected by ferroptosis might play an important role in the pathogenesis of this comorbidity.

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Association between Alzheimer's disease and risk of cancer: A retrospective cohort study in Shanghai, China

Abstract: Ru-Jing Ren, Qiang Huang, and Gang Xu contributed equally to this study.

Cited by 15 publications

References 55 publications

The China Alzheimer Report 2022

The China Alzheimer Report 2022

Oligomer‐Aβ42 suppress glioma progression via potentiating phagocytosis of microglia

Denoising autoencoder-based bulk and single-cell RNA-sequencing data analyses reveal a comorbidity relationship between Alzheimer’s disease and lung cancer

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