Association between methylenetetrahydrofolate reductase gene rs1801131 A/C polymorphism and urinary tumors’ susceptibility

Abstract

Background: The methylenetetrahydrofolate reductase (MTHFR) rs1801131 A/C variant results in a decrease in MTHFR enzymatic activity, which may play an important role in folate metabolism and is also an important source of DNA methylation and DNA synthesis. Several case-control studies have been conducted to assess the association of MTHFR rs1801131 polymorphism with the risk of urinary cancers, yet with conflicting conclusions. To derive a more precise estimation of above relationship, the association between the MTHFR rs1801131 A/C polymorphism and the risk of urinary cancer was performed. Methods: A total of 28 case-control studies was identified. The odds ratios (OR) with 95% confidence intervals (CI) was calculated to assess. Results: On one hand, we found that the MTHFR rs1801131 A/C polymorphism was associated with increased whole urinary cancers' risk (for example CA vs. AA: OR = 1.12. 95%CI = 1.01-1.24). On the other hand, we found that the MTHFR rs1801131 A/C polymorphism might increase bladder cancer risk both in Asian (C-allele vs.

A meta-analysis on the susceptibility to the development of bladder cancer in the presence of DNMT3A, DNMT3B, and MTHFR gene polymorphisms

“…Generally, no statistically significant association was observed between the rs1801131 polymorphism and the risk of developing BC. These results are supported by the work of Shi et al and Xu et al [46], [47]. On the other hand, it is interesting to highlight that the subgroups' analysis related to geographic regions revealed a protective effect of the rs1801131 allele in the North American population.…”

Associations of MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) Polymorphisms with Susceptibility to Bladder Cancer: A Systematic Review and Meta-Analysis

“…It was found that the rs1801133 (677C>T) in exon 4 and rs180113 (1298A>C) in exon 7 of the MTHFR gene resulted in amino acid substitution and a reduction of MTHFR activity ( Liu et al, 2020). To date, several epidemiological studies have evaluated the association of MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) polymorphisms with susceptibility to bladder cancer (You et al, 2013;Xu and Zuo, 2020). However, these associations were still inconclusive.…”