Automated on-line column-switching HPLC–MS/MS method for the quantification of triclocarban and its oxidative metabolites in human urine and serum

Urinary Concentrations of the Antibacterial Agent Triclocarban in United States Residents: 2013–2014 National Health and Nutrition Examination Survey

“…Of interest, the detection frequency and concentration ranges are comparable to results from previous studies in which triclocarban was detected in 28% ( N = 50) and 35% ( N = 158) of American adults with median urinary concentrations <0.1 μ g/L. 21,28 However, triclocarban was detected (LOD = 0.021 μ g/L) in 86.7% of 181 urine samples collected in 2007–2009 from pregnant women in New York City, with a median concentration of 0.21 μ g/L. 29 Outside the United States, triclocarban was rarely detected among Canadian women, potentially due to the use of a method with relatively low sensitivity (LOD = 1.1 μ g/L) to quantify triclocarban.…”

Maternal and infant exposure to environmental phenols as measured in multiple biological matrices

“…Triclocarban was rarely detected in any of the biospecimens tested in our study (4% of maternal urines), which may reflect limited use of this substance in Canada as well as a less sensitive method for measuring TCC (LOD in urine: 1.1 μg/L; whereas the CDC method had a LOD of 0.1 ng/mL and detected TCC in 35% of urines (Zhou et al, 2012)). An analysis of 100 urine samples in Greece for TCC (LOQ was 0.5 ng/mL) found only 4% with detectable concentrations (Asimakopoulos et al, 2014).…”

Rapid determination of X-ray contrast agent iomeprol in human plasma by on-line solid-phase extraction coupled with phase optimized liquid chromatography

“…In order to increase the efficiency, use of a fully automated analytical method could serve as an alternative by coupling a pre-column packed with a solid-phase extraction (SPE) sorbent to a LC column via the column switching technique. The automation of this sample clean-up avoids manual sample handling and increases the method precision, accuracy and sensitivity and allows for high throughput and low costs measurements [11][12][13]. However, few studies regarding the use of on-line SPE to extract non-ionic, iodinated X-ray contrast media agents (including IOM) from biological fluids have been reported.…”

“…The combination of the fast flow and large particle size provides the desired chromatographic behavior (turbulent flow behavior) that allows for the rapid passage of large biomolecules (MW cut off greater than 70 kDa) of the biological sample with the simultaneous retention of the small-molecule analyte(s) of interest [11,13]. In comparison with typical RAM-ADS sorbents, the relatively new Oasis HLB material with hydrophilic and lipophilic balance characteristics can be useful with compounds with a wide polarity range, and it is more stable over a wide pH range (pH range of 1-14) [8,18,19].…”