Biodistribution of protoporphyrin IX in female genital erosive lichen planus after topical application of hexaminolevulinate

Helgesen, Anne Lise Ording; Gjersvik, Petter; Peng, Qian; Vasovič, Vlada; Pripp, Are Hugo; Jebsen, Peter; Tanbo, Tom; Warloe, Trond

doi:10.1016/j.pdpdt.2014.01.005

Cited by 3 publications

(6 citation statements)

References 16 publications

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“…By monitoring the superficial fluorescence in every patient receiving PDT, we confirmed the induction and bleaching of PpIX in a standardized way (data not shown), as found in other studies . The mechanism of action of PDT in GELP and oral lichen planus is unknown but is thought to be linked to an effect on T lymphocytes …”

Section: Discussionsupporting

confidence: 87%

“…18,29 The mechanism of action of PDT in GELP and oral lichen planus is unknown but is thought to be linked to an effect on T lymphocytes. 26 We have reported the results using a conventional superiority trial design, although the study originally was designed as a noninferiority trial. We were not able to show noninferiority (data not shown).…”

Section: Discussionmentioning

confidence: 99%

“…18 In a microscopic fluorescence photometry study, we demonstrated photoactive protoporphyrin IX (PpIX) in both mucosal epithelium and submucosal tissue with high inflammatory activity in GELP lesions after topical application of HAL gel. 26 Based on these results, we have conducted a randomized controlled trial to assess the feasibility, efficacy and safety of one vulvovaginal HAL-PDT session in women with GELP compared with daily application of topical corticosteroids for 6 weeks.…”

mentioning

confidence: 99%

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Vulvovaginal photodynamic therapy vs. topical corticosteroids in genital erosive lichen planus: a randomized controlled trial

et al. 2015

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Vulvovaginal photodynamic therapy vs. topical corticosteroids in genital erosive lichen planus: a randomized controlled trial

et al. 2015

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“…Use of 5ALA in gynecologic cases now covers a broad spectrum of procedures (54–56) since PpIX was shown to accumulate in endometrial cancer cells by Wyss-Desserich and colleagues at non-toxic doses in 1996 (57). In this study, fluorescence was observed in vitro with best results found at 1 mg/ml incubated for 24 h and excited at 488 nm.…”

Section: Obstetrics and Gynecologymentioning

confidence: 99%

“…Topical absorption of 5ALA is effective in patients with cervical neoplasia (CIN) II and III, as well as with lichen planus (55, 56). A cervical cap with 2–4 mL of 200 mg/ml 5ALA placed for 1.5 h demonstrates that dysplastic cervical tissue consistently has greater fluorescence than normal tissue.…”

Section: Obstetrics and Gynecologymentioning

confidence: 99%

Delta-Aminolevulinic Acid-Mediated Photodiagnoses in Surgical Oncology: A Historical Review of Clinical Trials

et al. 2019

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Fluorescence imaging is an emerging clinical technique for real-time intraoperative visualization of tumors and their boundaries. Though multiple fluorescent contrast agents are available in the basic sciences, few fluorescence agents are available for clinical use. Of the clinical fluorophores, delta aminolevulinic acid (5ALA) is unique for generating visible wavelength tumor-specific fluorescence. In 2017, 5ALA was FDA-approved for glioma surgery in the United States. Additionally, clinical studies suggest this agent may have utility in surgical subspecialties outside of neurosurgery. Data from dermatology, OB/GYN, urology, cardiothoracic surgery, and gastrointestinal surgery show 5ALA is helpful for intraoperative visualization of malignant tissues in multiple organ systems. This review summarizes data from English-language 5ALA clinical trials across surgical subspecialties. Imaging systems, routes of administration, dosing, efficacy, and related side effects are reviewed. We found that modified surgical microscopes and endoscopes are the preferred imaging devices. Systemic dosing across surgical specialties range between 5 and 30 mg/kg bodyweight. Multiple studies discussed potential for skin irritation with sun exposure, however this side effect is infrequently reported. Overall, 5ALA has shown high sensitivity for labeling malignant tissues and providing a means to visualize malignant tissue not apparent with standard operative light sources.

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Photodynamic therapy of oral lichen planus

Hesse

Schmalfuss

2020

Photochem Photobiol Sci

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Biodistribution of protoporphyrin IX in female genital erosive lichen planus after topical application of hexaminolevulinate

Cited by 3 publications

References 16 publications

Vulvovaginal photodynamic therapy vs. topical corticosteroids in genital erosive lichen planus: a randomized controlled trial

Vulvovaginal photodynamic therapy vs. topical corticosteroids in genital erosive lichen planus: a randomized controlled trial

Delta-Aminolevulinic Acid-Mediated Photodiagnoses in Surgical Oncology: A Historical Review of Clinical Trials

Photodynamic therapy of oral lichen planus

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