Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran. III. Antiviral activity

Mayer, Alejandro M. S.; Díaz, Alcira Ofélia; Pesce, Analia; Criscuolo, Marcelo; Groisman, Jose F.; Lederkremer, Rosa M. de

doi:10.1007/978-94-009-4057-4_73

Cited by 5 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SPs extracts of Mexican Macrocystis pyrifera showed a significant antiviral effect but were not selected for subsequent assays because of their IC 50 value ( Table 1 ). Previous studies with crude dialyzed extracts of Macrocystis pyrifera have shown antiviral effects against VSV, with the fucoidan being responsible for these results [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effects of Sulfated Polysaccharides from Mexican Seaweeds against Measles Virus

Morán-Santibañez

Cruz‐Suárez

Ricque‐Marie

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

Sulfated polysaccharides (SPs) extracted from five seaweed samples collected or cultivated in Mexico (Macrocystis pyrifera, Eisenia arborea, Pelvetia compressa, Ulva intestinalis, and Solieria filiformis) were tested in this study in order to evaluate their effect on measles virus in vitro. All polysaccharides showed antiviral activity (as measured by the reduction of syncytia formation) and low cytotoxicity (MTT assay) at inhibitory concentrations. SPs from Eisenia arborea and Solieria filiformis showed the highest antiviral activities (confirmed by qPCR) and were selected to determine their combined effect. Their synergistic effect was observed at low concentrations (0.0274 μg/mL and 0.011 μg/mL of E. arborea and S. filiformis SPs, resp.), which exhibited by far a higher inhibitory effect (96% syncytia reduction) in comparison to the individual SP effects (50% inhibition with 0.275 μg/mL and 0.985 μg/mL of E. arborea and S. filiformis, resp.). Time of addition experiments and viral penetration assays suggest that best activities of these SPs occur at different stages of infection. The synergistic effect would allow reducing the treatment dose and toxicity and minimizing or delaying the induction of antiviral resistance; sulfated polysaccharides of the tested seaweed species thus appear as promising candidates for the development of natural antiviral agents.

show abstract

Section: Discussionmentioning

confidence: 99%

Synergistic Effects of Sulfated Polysaccharides from Mexican Seaweeds against Measles Virus

Morán-Santibañez

Cruz‐Suárez

Ricque‐Marie

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…As can be seen in Figure 5, the antiviral properties of alginate against HIV-1 60,76,77 and HSV-1 51−53,61,67−69 are the most frequently studied, followed by HCV, 60,61 HSV-2, 50,68 TMV, 63,75 PV-1, 61,67 and MNV and HAV. 54,59 Alginate-based materials have also been tested against HBV, 60 SINV, 61 RAV, 46 PVX, 48 IFV, 62 VSV, 49 HTLV-1, 60 RV, 47 T4, 72 and HIV-1(VSV). 60 Of these 32 studies, 25 showed viral inhibition, which suggest that alginate-based materials have significant potential as alternative antiviral agents.…”

Section: Alginate-based Materials Against Virusesmentioning

confidence: 99%

“…Thus, a strong antiviral effect of SA at a concentration of 1 μg/μL –1 against PVX was demonstrated. However, a few studies of SA have reported no antiviral activity, as sodium alginate and mannuronic-acid-rich alginate did not show any inhibition effect against vesicular stomatitis virus (VSV) or against herpes simplex virus type 2 (HSV-2), respectively. Alginate hydrogels have also been shown to possess antiviral capacity against herpes simplex virus type 1 (HSV-1) when used as a sulfated compound was dependent on the sulfate contents of the polysaccharides and the chemical properties of the sulfated alginate .…”

Section: Alginate-based Materials With Antiviral Propertiesmentioning

confidence: 99%

Antiviral Properties of Alginate-Based Biomaterials: Promising Antiviral Agents against SARS-CoV-2

Serrano‐Aroca

Ferrandis-Montesinos

Wang

2021

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

The COVID-19 pandemic has made it essential to explore alternative antiviral materials. Alginate is a biodegradable, renewable, biocompatible, water-soluble and antiviral biopolymer with many potential biomedical applications. In this regard, this review shows 17 types of viruses that have been tested in contact with alginate and its related biomaterials. Most of these studies show that alginate-based materials possess little or no toxicity and are able to inhibit a wide variety of viruses affecting different organisms: in humans by the human immunodeficiency virus type 1, the hepatitis A, B, and C viruses, Sindbis virus, herpes simplex virus type 1 and 2, poliovirus type 1, rabies virus, rubella virus, and the influenza virus; in mice by the murine norovirus; in bacteria by the T4 coliphage, and in plants by the tobacco mosaic virus and the potato virus X. Many of these are enveloped positive-sense single-stranded RNA viruses, like SARS-CoV-2, which render alginate-based materials highly promising in the COVID-19 pandemic.

show abstract

“…In addition, by interfering with cell–cell recognition in mammalian systems, they display a variety of biological activities. They inhibit the acrosomal reaction in human spermatozoa (Mahony et al, 1991 , 1993 ) and block infections by such viruses as the human immunodeficiency virus (Béress et al, 1993 ; Hoshino et al, 1998 ), the vesicular stomatitis virus (Mayer et al, 1987 ), and the herpes simplex virus (Hoshino et al, 1998 ), as well as by other microbes, such as Plasmodium knowlesi (Dalton et al, 1991 ). Sulfated fucans are potent inhibitors of smooth muscle cell growth, both in vitro and in vivo (McCaffrey et al, 1992 ; Logeart et al, 1997 ), and they display antiproliferative activity in various cancer types, including a non–small–cell bronchopulmonary carcinoma line (Riou et al, 1996 ) and Erhlich carcinoma (Zhuang et al, 1995 ).…”

Section: Introductionmentioning

confidence: 99%

Isolation and Culture of a Marine Bacterium Degrading the Sulfated Fucans from Marine Brown Algae

et al. 2006

View full text Add to dashboard Cite

Fucoidans are matrix polysaccharides from marine brown algae, consisting of an α-l-fucose backbone substituted by sulfate-ester groups and masked with ramifications containing other monosaccharide residues. In spite of their interest as biologically active compounds in a number of homologous and heterologous systems, no convenient sources with fucanase activity are available yet for the degradation of the fucalean algae. We here report on the isolation, characterization, and culture conditions of a bacterial strain capable of degrading various brown algal fucoidans. This bacterium, a member of the family Flavobacteriaceae, was shown to secrete fucoidan endo-hydrolase activity. An extracellular enzyme preparation was used to degrade the fucoidan from the brown alga Pelvetia canaliculata. End products included a tetrasaccharide and a hexasaccharide made of the repetition of disaccharidic units consisting of α-1→3-l-fucopyranose-2-sulfate-α-1→4-l-fucopyranose-2,3-disulfate, with the 3-linked residues at the nonreducing end.

show abstract

Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran. III. Antiviral activity

Cited by 5 publications

References 9 publications

Synergistic Effects of Sulfated Polysaccharides from Mexican Seaweeds against Measles Virus

Synergistic Effects of Sulfated Polysaccharides from Mexican Seaweeds against Measles Virus

Antiviral Properties of Alginate-Based Biomaterials: Promising Antiviral Agents against SARS-CoV-2

Isolation and Culture of a Marine Bacterium Degrading the Sulfated Fucans from Marine Brown Algae

Contact Info

Product

Resources

About