Buccoadhesive drug delivery system of isosorbide dinitrate: Formulation and evaluation

Doijad, RC; Manvi, F. V.; Rao, V.S.N Malleswara; Ps, Patel

doi:10.4103/0250-474x.31007

Cited by 21 publications

(14 citation statements)

References 2 publications

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“…The films were prepared by the method of solvent casting technique employing 'O' shape ring placed on a glass surface as substrate. [6,7,8] Composition of a single circular cast film of various formulations is given in the Table 1. The calculated quantities of polymers Hydroxy Propyl Methyl Cellulose -15 cps (HPMC) and Poly Vinyl Pyrrolidone (PVP) were dispersed in 10ml of mixture of methanol and dichloromethane in ratio 1:1.…”

Section: Fabrication Of Timolol Maleate Buccal Patchmentioning

confidence: 99%

Development and Characterization of Mucoadhesive Buccal Patch of Timolol Maleate

Sharma¹,

Khan

Singh³

2018

J App Pharm Sci Res

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Introduction:The oral transmucosal Timolol maleate delivery bypasses liver and avoids presystemic elimination in the gastro intestinal tract and liver which enhance the bioavailability as well decreases the adverse effect. Objective: The present investigation highlights the formulation and evaluation of mucoadhesive buccal patch of Timolol maleate because Timolol maleate has biphasic solubility hence relatively permeated through buccal mucosa, which is well supplied with both vascular and lymphatic drainage. Material and Method: The mucoadhesive buccal patches of Timolol maleate were prepared by solvent casting technique using polymers like Hydroxypropylmethyl cellulose-15cps and Polyvinyl pyrrolidone. The formulated films were evaluated for their physiochemical parameters like surface pH, percentage moisture absorption, swelling percentage, thickness, folding endurance and drug content. In vitro permeation and in vitro release studies were performed with pH 6.8 phosphate buffer solution. Result and Discussion: The patches exhibited controlled release for more than 12 h. The in vitro release data were fit to different equations and kinetic models to explain release profiles. The kinetic models used were zero order, first order higuchi's and peppa's. The best mucoadhesive performance and matrix controlled release was exhibited by the formulation CK2 (3 % HPMC and 1 % PVP). Conclusion: Good results were obtained both in physico chemical characteristics and in vitro studies in formulation CK2. Hence the formulations of Timolol maleate bioadhesive buccal patch is a promising one as the controlled drug delivery with improved bioavailability. , Khan AD, Sachdeva M. Development and characterization of mucoadhesive buccal patch of timolol Journal of Applied Pharmaceutical Sciences and Research. 2018; 1(1):8-15. Development and Characterization of Buccal patch 15 batches C, AK2, BK2 and CK2 between log % cumulative drug releases vs. log time. Thimmasetty J, Pandey GS, Babu PR Sathesh. Design and in evaluation of carvedilol buccal mucoadhesive patches.

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Section: Fabrication Of Timolol Maleate Buccal Patchmentioning

confidence: 99%

Development and Characterization of Mucoadhesive Buccal Patch of Timolol Maleate

Sharma¹,

Khan

Singh³

2018

J App Pharm Sci Res

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“…Variation in thickness and weight between different formulations may be due to differences in density, molecular weight, and viscosity of the different polymers (28). Table I point out the small thickness (15-27 μm) and weight values (16-27 mg) of the prepared inserts, which is considered advantageous for nasal application.…”

Section: Drug Content Weight Uniformity and Thickness Of The Insertsmentioning

confidence: 99%

Formulation and In Vitro Evaluation of Salbutamol Sulphate In Situ Gelling Nasal Inserts

et al. 2013

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The aim of this study was to formulate salbutamol sulfate (SS), a model drug, as mucoadhesive in situ gelling inserts having a high potential as nasal drug delivery system bypassing the first-pass metabolism. In situ gelling inserts, each containing 1.4% SS and 2% gel-forming polymer, hydroxypropyl methylcellulose (HPMC), carboxymethylcellulose sodium (CMC Na), sodium alginate (AL), and chitosan (CH) were prepared. The inserts were investigated for their different physicochemical properties. The weight of inserts was 16-27 mg, drug content was 3.9-4.2 mg, thickness ranged between 15 and 28 μm and surface pH was 5-7. Cumulative drug released from the inserts exhibited extended release for more than 10 h following the decreasing order: CH>AL>CMC Na>HPMC. The drug release from CMC Na and AL inserts followed zero-order kinetics while HPMC and CH inserts exhibited non-Fickian diffusion mechanism. The inserts exhibited different water uptake (7-23%) with the smallest values for CH. Differential scanning calorimetry study pointed out possible interaction of SS and oppositely charged anionic polymers (CMC Na and AL). The mucoadhesive in situ gelling inserts exhibited satisfactory mucoadhesive and extended drug release characteristics. The inserts could be used for nasal delivery of SS over about 12 h; bypassing the hepatic first-pass metabolism without potential irritation.

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“…After solvent evaporation a thin layer of the protective backing material is laminated onto the sheet of coated release liner to form a laminate that is die-cut to form patches of the desired size and geometry 19,20,21 .…”

Section: Solvent Castingmentioning

confidence: 99%

Untitled

2013

IJPSR

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Buccal route is an attractive route of administration for systemic drug delivery and it leads direct access to the systemic circulation through the internal jugular vein bypasses drugs from the hepatic first pass metabolism provides high bioavailability. Buccalbioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms for treatment of many diseases. This article aims to review the recent developments in the buccal adhesive drug delivery systems to provide basic principles to the young scientists, which will be useful to circumvent the difficulties associated with the formulation design.

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Buccoadhesive drug delivery system of isosorbide dinitrate: Formulation and evaluation

Cited by 21 publications

References 2 publications

Development and Characterization of Mucoadhesive Buccal Patch of Timolol Maleate

Development and Characterization of Mucoadhesive Buccal Patch of Timolol Maleate

Formulation and In Vitro Evaluation of Salbutamol Sulphate In Situ Gelling Nasal Inserts

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