Can Zn Be a Critical Element in COVID-19 Treatment?

Rahman, Mohammad Tariqur; Idid, Syed Zahir Idid Syed Osman

doi:10.1007/s12011-020-02194-9

Cited by 138 publications

(148 citation statements)

References 95 publications

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“…Zinc is one of the micronutrients that could be consumed to reduce the intensity of SARS-CoV-2 infection and perhaps lessen the respiratory tract infection through the antiviral actions [7]. Zinc de ciency can contribute to defective cell-mediated immunity and to increased susceptibility to various infections, including pneumonia [31]. Several lines of evidence suggest a link between zinc and COVID-19, including the observation that chloroquine, a drug being repurposed for COVID-19, is a known zinc ionophore [32].…”

Section: Discussionmentioning

confidence: 99%

Associations of blood essential and toxic metal(loid)s with both disease severity and mortality in patients with COVID-19: a retrospective study

Zeng

Yang

Yuan

et al. 2020

Preprint

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Background The variations and dynamics of blood essential and toxic metal(loid)s in patients with COVID-19 still remains unclear.Methods A retrospective study was performed in a cohort of confirmed COVID-19 patients for their whole blood levels of essential and/or toxic metal(loid)s including magnesium, calcium, chromium, manganese, iron, copper, zinc, arsenic, cadmium, mercury, thallium and lead according to the disease severity and outcome.Results Compared to the non-severe COVID-19 patients, Whole blood calcium, chromium and copper were higher in the severe patients, while magnesium, manganese, iron, zinc, arsenic, thallium and lead were lower. These differences were further found to be consistently existed across the clinical course since the disease onset by longitudinal analysis. Moreover, among the severe patients, chromium and cadmium were higher in the deceased group compared to the recovered group, while arsenic were found to be lower. Whole blood iron, arsenic, and age and sex were determined to be independently factors associated with the disease severity, while chromium, cadmium and the co-morbidity of cardiovascular disease were determined to be independently factors associated with the mortality.Conclusions These results suggest variations of whole blood metal(loid)s as associated factors correlated with the disease severity and mortality for COVID-19.

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Section: Discussionmentioning

confidence: 99%

Associations of blood essential and toxic metal(loid)s with both disease severity and mortality in patients with COVID-19: a retrospective study

Zeng

Yang

Yuan

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Proliferation and function of NK cells, macrophages, neutrophils, T and B cells, and also the production of cytokines can be controlled by zinc [10]. Also, zinc can protect cells from the effect of reactive oxygen species [11]. Zinc is involved in the controls of common cold due to its inhibitory mechanism in viral replication [12] and attachment to the nasopharyngeal mucous, and there is any evidence that it decreases the duration of common cold about 1.65 days.…”

Section: Zincmentioning

confidence: 99%

“…Pyrithione also is a zinc ionophore, so using zinc with a low amount of pyrithione inhibits the SARS coronavirus replication [6]. Some antiviral drugs can be more efficient by using zinc, and their abdominal discomfort will decrease [11]. Using a combination of CQ, zinc, and azithromycin as eye drops or spray/aerosol for eyelids and the ocular surface can prevent binding of SARS-CoV-2 to the eyes as one of the major pathways of importing the virus into the body [21].…”

Section: Zincmentioning

confidence: 99%

A Review on the Serum Electrolytes and Trace Elements Role in the Pathophysiology of COVID-19

Taheri

Bahrami

Habibi

et al. 2020

Biol Trace Elem Res

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All the world is involved in the COVID-19 disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus is a positive-sense RNA and has an envelope. There is no specific drug for this disease and treatment methods are limited. Malnutrition and electrolyte imbalance can make dysfunction in the immune system and impairment of the immune system causes increasing the risk of infection. Understanding the aspects of biological features of the virus will help the development of diagnostic tests, pharmacological therapies, and vaccines. Here, we review and discuss increasing and decreasing some trace elements and imbalance of serum and plasma electrolytes involving in COVID-19.

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“…• Zinc has the ability to enhance innate and adaptive immunity in the course of viral infection [40].…”

Section: Q21: What Is the Role Of Zinc In Covid-19?mentioning

confidence: 99%

A Simplified Approach to Covid-19 Disease in Adult Patients for General Practitioners

Yahia¹

2020

Int J Respir Pulm Med

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The pandemic of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a challenge to all doctors worldwide for detection of disease, differentiating it from those with similar presenting symptoms. The initial evaluation of the patient with suspected Covid-19 disease is usually performed by general practitioners; who, unfortunately; as their knowledge about the on growing changing faces of this pandemic disease presenting symptoms and evolving new information are not continually updated, miss the diagnosis of some cases, with fatal consequences to these cases. This simplified review is intended to provide those doctors basic, quick but essential information that will enable them to better at detecting and diagnosing cases. The current medical literature that is applicable to this simplified review was identified by a computerized search in WHO and the CDC, websites and in most of the reputed English language printed medical journals and was evaluated using standardized methods till the time of publication.

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Can Zn Be a Critical Element in COVID-19 Treatment?

Cited by 138 publications

References 95 publications

Associations of blood essential and toxic metal(loid)s with both disease severity and mortality in patients with COVID-19: a retrospective study

Associations of blood essential and toxic metal(loid)s with both disease severity and mortality in patients with COVID-19: a retrospective study

A Review on the Serum Electrolytes and Trace Elements Role in the Pathophysiology of COVID-19

A Simplified Approach to Covid-19 Disease in Adult Patients for General Practitioners

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