Ceruloplasmin Its Role and Significance: A Review

Gaware, Vinayak M; Kotade, Kiran B; Dhamak, Kiran B; Somawanshi, Sachin

doi:10.7439/ijbr.v1i4.69

Cited by 23 publications

(23 citation statements)

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“…These differences may be due to small sample size, application of different methods, clinical features, and ethnobiological variations of the patients. Effects of other medical conditions on Cp levels have been shown in such as liver function deteriorations, pregnancy, oral contraceptive use, lymphoma, infections, angina and other disease-states [5,23]. A similar physical disease or conditions have not been present in any of our patients.…”

Section: Discussionmentioning

confidence: 53%

“…It plays an essential role in iron homeostasis through Cp-ferroxidase activity. Unbound ferrous iron ions (Fe+2) are oxidized into ferric iron ions (Fe+3) and thus associates transferrin and delivered in the blood [1,2,4,5]. The oxidase activity of Cp also has a high affinity for Cu defining its status [5].…”

Section: Introductionmentioning

confidence: 99%

“…Unbound ferrous iron ions (Fe+2) are oxidized into ferric iron ions (Fe+3) and thus associates transferrin and delivered in the blood [1,2,4,5]. The oxidase activity of Cp also has a high affinity for Cu defining its status [5]. Therefore, abnormal levels or insufficient functioning of Cp is found to be associated with iron and copper related pathologies [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study

Tunç

Atagün

Başbuğ

et al. 2019

Psychiatry and Clinical Psychopharmacology

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OBJECTIVE: In this study, we aimed to study copper metabolism in schizophrenia, bipolar disorder, major depression compared with healthy control. METHODS: This is a single-centered cross-sectional study. The patients with schizophrenia (n = 36), bipolar disorder (n = 37), major depression (n = 40), and healthy control (n = 32) were included in the study. All participants were initially evaluated by a clinical psychiatrist to confirm the appropriate diagnosis using the Structured Clinical Interview for Diagnostic and Statistical Manuel of Mental Disorders-IV (DSM-IV) Axis I Disorders (SCID-I). Serum copper level, ceruloplasmin mass, and ceruloplasmin-ferroxidase activity were measured. One-way ANOVA and Kruskal-Wallis Tests were performed for statistical analyses. RESULTS: Serum ceruloplasmin-ferroxidase activity (χ 2 = 9.11, p = 0.028) demonstrated a significant statistical difference in all groups compared with the control group. Serum ceruloplasmin-ferroxidase activity of the bipolar disorder group was significantly higher than the healthy control group (p = 0.012), major depression group (p = 0.027), and the schizophrenia group (p = 0.019). Erythrocyte sedimentation rate (ESR) (p = 0.028) and waist circumference (p = 0.005) in bipolar disorder group, and the C-reactive protein (CRP) (p < 0.001) and cholesterol (p = 0.043) in the schizophrenia group were found as the determinants of ceruloplasmin-ferroxidase activity. CONCLUSION: In this study, ceruloplasmin-ferroxidase activity is higher in all groups in comparison to the healthy control. The significantly higher ceruloplasmin-ferroxidase activity was shown in bipolar disorder followed by the major depression and schizophrenia. The ceruloplasmin-ferroxidase activity was correlated with erythrocyte sedimentation rate in the bipolar disorder group and with C-reactive protein in the schizophrenia group. Therefore, the ceruloplasmin-ferroxidase activity may be an encouraging candidate in the neuro-immune modulation and become a reliable clinical tool for demonstrating the strong association of inflammation in these disorders.

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Section: Discussionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study

Tunç

Atagün

Başbuğ

et al. 2019

Psychiatry and Clinical Psychopharmacology

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“…Serum samples were used to investigate the level of CP because it is mainly synthesized by the liver and then secreted into the blood. CP is also the major copper-carrying protein in the blood [21] .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the serum ceruloplasmin level before and after non-surgical periodontal therapy in patients with chronic periodontitis

Mohammed¹,

Youssef²,

Metwally³

et al. 2018

SDS

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Aim: This study aimed to evaluate the serum ceruloplasmin (CP) level after non-surgical periodontal therapy in chronic periodontitis patients.Methods: A prospective controlled study was conducted on 80 subjects. The study populations were divided into 2 groups: group 1 included chronic periodontitis patients (study group, n = 40), and group 2 included periodontally healthy subjects (control group, n = 40). Blood sample and periodontal clinical parameters, including periodontal pocket depth, clinical attachment level and bleeding on probing, were performed at baseline for both groups. All of the patients with chronic periodontitis (study group) received meticulous scaling and root planing twice weekly for 2 weeks. Four weeks after treatment, the second blood sample and reevaluation of clinical periodontal parameters were done. Results:Baseline serum CP level was significantly higher in chronic periodontitis patients (study group) compared to healthy subjects (control group) (P < 0.001). Concerning the chronic periodontitis group, four weeks after non-surgical periodontal therapy, the mean value of serum CP concentration was significantly decreased (P < 0.001). Conclusion:Non-surgical periodontal therapy has a reducing effect on the serum CP level in chronic periodontitis patients.Serum CP level represents a potential biomarker indicator of the chronic periodontitis disease.

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“…The molecular weight of human ceruloplasmin is reported to be 151kDa. [25] Sweeney SC studied alterations in tissue and serum Ceruloplasmin (Cp) concentration associated with inflammation and stated that the amount of ceruloplasmin in man during periodontal disease was increased approximately 15 times at the injured site in gingival tissues. [26] Harshavardhana MB et al evaluated serum ceruloplasmin in aggressive and chronic periodontitis patients and concluded serum ceruloplasmin levels increased in both aggressive and chronic periodontitis patients, but more in aggressive periodontitis patients making it a potential marker for diagnosis of periodontitis.…”

Section: Fibrinogenmentioning

confidence: 99%