Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats

Maschio, Bianca Hessel; Gentil, Bianca Carvalho; Caetano, Érika Leão Ajala; Rodrigues, Lucas S.; Laurino, Leticia Favara; Spim, Sara Rosicler Vieira; Jozala, Ângela Faustino; Santos, Carolina Alves dos; Grotto, Denise; Gerenutti, Marli

doi:10.1615/intjmedmushrooms.2017024498

Cited by 8 publications

(4 citation statements)

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“…The ginsenosides are not detected in the blood after ginseng and ginsenoside Re treatment due to poor systemic bioavailability of ginsenosides [ 28 ]. Shiitake mushroom, which is rich in β-glucans and vitamin D, also has anti-diabetic activities [ 5 , 38 , 39 ]. β-glucan changes the gut microbiome and may be associated with improving insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Combination of Aronia, Red Ginseng, Shiitake Mushroom and Nattokinase Potentiated Insulin Secretion and Reduced Insulin Resistance with Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic Rats

et al. 2018

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The combination of freeze-dried aronia, red ginseng, ultraviolet-irradiated shiitake mushroom and nattokinase (AGM; 3.4:4.1:2.4:0.1) was examined to evaluate its effects on insulin resistance, insulin secretion and the gut microbiome in a non-obese type 2 diabetic animal model. Pancreatectomized (Px) rats were provided high fat diets supplemented with either (1) 0.5 g AGM (AGM-L), (2) 1 g AGM (AGM-H), (3) 1 g dextrin (control), or (4) 1 g dextrin with 120 mg metformin (positive-control) per kg body weight for 12 weeks. AGM (1 g) contained 6.22 mg cyanidin-3-galactose, 2.5 mg ginsenoside Rg3 and 244 mg β-glucan. Px rats had decreased bone mineral density in the lumbar spine and femur and lean body mass in the hip and leg compared to the normal-control and AGM-L and AGM-H prevented the decrease. Visceral fat mass was lower in the control group than the normal-control group and its decrease was smaller with AGM-L and AGM-H. HOMA-IR was lower in descending order of the control, positive-control, AGM-L, AGM-H and normal-control groups. Glucose tolerance deteriorated in the control group and was improved by AGM-L and AGM-H more than in the positive-control group. Glucose tolerance is associated with insulin resistance and insulin secretion. Insulin tolerance indicated insulin resistance was highly impaired in diabetic rats, but it was improved in the ascending order of the positive-control, AGM-L and AGM-H. Insulin secretion capacity, measured by hyperglycemic clamp, was much lower in the control group than the normal-control group and it was improved in the ascending order of the positive-control, AGM-L and AGM-H. Diabetes modulated the composition of the gut microbiome and AGM prevented the modulation of gut microbiome. In conclusion, AGM improved glucose metabolism by potentiating insulin secretion and reducing insulin resistance in insulin deficient type 2 diabetic rats. The improvement of diabetic status alleviated body composition changes and prevented changes of gut microbiome composition.

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Section: Discussionmentioning

confidence: 99%

Combination of Aronia, Red Ginseng, Shiitake Mushroom and Nattokinase Potentiated Insulin Secretion and Reduced Insulin Resistance with Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic Rats

et al. 2018

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“…Four weeks of CCl4 therapy resulted in a reasonable amount of collagen fibril deposition. 43 Syringic acid and vanillic acid clearly suppressed collagen aggregation and significantly decreased hepatic hydroxyproline content, which is a quantitative marker of fibrosis, according to Azan-stained liver parts. 44 Both of these compounds held hepatocyte viability while inhibiting the activation of cultured hepatic stellate cells, which play a key role in liver fibrogenesis.…”

Section: Hepatoprotective Activity:-mentioning

confidence: 95%

A Review of the Pharmacological Characteristics of Vanillic Acid

Ingole

Kadam²,

Dalu³

et al. 2021

J. Drug Delivery Ther.

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A dihydroxybenzoic acid analog used as a flavoring agent is vanillic acid (4hydroxy-3-methoxybenzoic acid). It's a form of vanillin that has been oxidized. It's also a step in the process of making vanillin from Ferulic Acid. Vanillic acid has seen a lot of press because of its many uses in the cosmetics, fruit, flavorings, cigarettes,alcohols, drinks, and polymer sectors. It's said to have effective antioxidant, anti-inflammatory, and neuroprotective properties. The pharmacological impact on oxidative stress-induced neuro-degeneration, on the other hand, have not been thoroughly examined. The pharmacological properties of vanillic Acid lead to its possible use in the treatment of various diseases. Keywords: Vanillic acid, Pharmacological Potential, wound healing, Antioxidants

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“…Regular consumption of this mushroom can increase immune function, improve the metabolic profile and reduce lipid levels and oxidative stress [14,15]. A previous study from our working group correlated the Lentinus edodes exposure with improvement in severe GDM [16]. Otherwise, we aimed to investigate the safety use of Lentinus edodes as a therapeutic aid in two GDM conditions: (i) exposure to Lentinus edodes from gestational day 1 to 19 (before fetus implantation) and (ii) exposure to Lentinus edodes from gestation day 9 to 19 (after fetus implantation), considering their potentialities as functional food.…”

Section: Introductionmentioning

confidence: 99%

Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus

et al. 2019

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Background: The presence of β-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and Lentinus edodes exposure was performed in diabetes mellitus rat model induced by streptozotocin in pre-clinical tests. Methods: On the 20th day of pregnancy, cesarean sections were performed. Blood was collected for biochemical, hematologic parameters and oxidative stress biomarkers. Placenta and amniotic fluid were collected, and fetuses were analyzed through morphological evaluation. Results: The mushroom did not reduce the severe hyperglycemia of the mother-concept but promoted an increase in maternal insulin levels; reduced the levels of alanine aminotransferase, and aspartate aminotransferase, triglyceride and total cholesterol; protected the animals from post-implantation losses. Liver damage induced by streptozotocin was reversed in experimental groups. Conclusions: Lentinus edodes mushroom has antioxidant properties that can minimize the damage caused by gestational diabetes mellitus.

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Characterization of the Effects of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), on Severe Gestational Diabetes Mellitus in Rats

Cited by 8 publications

References 0 publications

Combination of Aronia, Red Ginseng, Shiitake Mushroom and Nattokinase Potentiated Insulin Secretion and Reduced Insulin Resistance with Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic Rats

Combination of Aronia, Red Ginseng, Shiitake Mushroom and Nattokinase Potentiated Insulin Secretion and Reduced Insulin Resistance with Improving Gut Microbiome Dysbiosis in Insulin Deficient Type 2 Diabetic Rats

A Review of the Pharmacological Characteristics of Vanillic Acid

Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus

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