With the development of integrated circuits, the power consumption becomes a key problem in the design of integrated circuits. Reducing the operating voltage is an effective way to reduce power consumption. But the chip working voltage is reduced, brings more challenges to the chip design, which is mainly composed of process, voltage and temperature (PVT) variation instability on the performance of chips. According to the problem of clock tree network structure under low voltage, this paper puts forward a method of resistance process, voltage and temperature (PVT) variation clock tree design under low voltage, enhancing the stability of the chip, and ensuring the effectiveness of low voltage design.