Clinical Trials of Silver Diamine Fluoride in Arresting Caries among Children

Gao, Sherry Shiqian; Zhao, Irene Shuping; Hiraishi, Noriko; Duangthip, Duangporn; Mei, May Lei; Lo, Edward Chin Man

doi:10.1177/2380084416661474

Cited by 214 publications

(254 citation statements)

References 20 publications

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“…And finally, there is a clear need for the continued evolution of well-designed, randomized, clinical trials to produce studies with a low risk of bias during the planning, execution, and reporting of results. Standardization in the presentation of data between studies, 18,51 whether they focus on arrest or prevention, is imperative to be able to combine and translate the data into strong clinical guidelines. As indicated, clinicians need to know how to manage arrested lesions for longer periods, which is important for very young children and imperative for permanent teeth.…”

Section: Current Evidence On the Efficacy Of Silver Diamine Fluoride mentioning

confidence: 99%

Evidence-Based Dentistry Update on Silver Diamine Fluoride

Crystal

Niederman

2019

Dental Clinics of North America

153

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Section: Current Evidence On the Efficacy Of Silver Diamine Fluoride mentioning

confidence: 99%

Evidence-Based Dentistry Update on Silver Diamine Fluoride

Crystal

Niederman

2019

Dental Clinics of North America

153

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“…A randomised, controlled trial concluded that 38% SDF had a better result than the interim restorative treatment using glass ionomer cements (GICs) to arrest cavitated caries in primary teeth. A systematic review confirmed that 38% SDF was effective in arresting dentine caries in deciduous teeth among children. Additionally, caries removal is not needed before application of SDF, which can simplify treatment procedures.…”

Section: Introductionmentioning

confidence: 99%

Effect of silver diamine fluoride and potassium iodide on shear bond strength of glass ionomer cements to caries-affected dentine

Zhao

Chu

et al. 2019

International Dental Journal

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Objective To investigate the effect of silver diamine fluoride (SDF) and potassium iodide (KI) treatment on dentine discolouration and the shear bond strength (SBS) of glass ionomer cements (GICs) to artificial caries‐affected dentine. Materials and methods Dentine slices from human molars were demineralised to mimic caries‐affected dentine. They were randomly allocated for treatment (n = 20 per treatment) with SDF + KI, SDF (positive control) or water (negative control). All slices were immersed in the artificial saliva for 24 hours after treatments. The colour of the treated surfaces was assessed using the CIELAB system. Lightness values were measured. Total colour change (∆E) was calculated using water as the reference group, and was visible to the naked eyes if ∆E > 3.7. All dentine slices were bonded with GICs. The SBS was assessed using a universal testing machine. Colour parameters and the SBS were analysed using a one‐way ANOVA test. Results The slices treated with SDF + KI had a higher lightness value those slices treated with water, whereas those treated with SDF presented a lower lightness value compared with those treated with water. The treatment with SDF + KI did not introduce any adverse colour effect to demineralised dentine (∆E = 14.4), whereas the application of SDF alone caused significant staining (∆E = 24.6). The SBS values (mean ± SD) after treatment with SDF + KI, SDF and water were 3.0 ± 1.4 MPa, 2.3 ± 0.9 MPa and 2.6 ± 1.1 MPa, respectively (P = 0.217). Conclusion The immediate application of KI solution after SDF treatment does not negatively affect adhesion of GICs to artificial caries‐affected dentine. Moreover, KI treatment can reduce discolouration of demineralised dentine caused by SDF.

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“…Recently, 2 systematic reviews have been published about professionally applied fluoride treatment [Gao et al, 2016b] and SDF [Gao et al, 2016a]. They both affirmed that SDF is effective in controlling caries progression.…”

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confidence: 99%

“…We only included RCTs with at least a 12-month follow-up period, which resulted in 11 papers. The recently published review on SDF [Gao et al, 2016a] included 19 papers, but the authors did not set a minimum follow-up period, included the same study (with different follow-ups) in the same meta-analysis, and allowed studies without control groups to be included. Additionally, they included in their search data from the China National Knowledge Infrastructure and Ichusi-web databases resulting in the inclusion of papers written in Chinese and Japanese.…”

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confidence: 99%

“…Our option was to meta-analyze the SDF compared to active treatments or to placebo, including only papers judged as being at "low" or "unclear" risk of bias, unlike the former meta-analysis [Gao et al, 2016a] that centered the comparison on the follow-up periods and also used papers classified as being at "high" risk, leading to a high level of heterogeneity and reducing the confidence in the summary estimates. By including in the present study articles with low/unclear risk of bias and reporting the same outcome, we have not observed heterogeneity neither in the subgroup analysis nor in overall analysis.…”

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confidence: 99%

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Silver Diamine Fluoride Has Efficacy in Controlling Caries Progression in Primary Teeth: A Systematic Review and Meta-Analysis

Chibinski

Wambier²,

Feltrin³

et al. 2017

Caries Res

157

175

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A systematic review was performed to evaluate the efficacy of silver diamine fluoride (SDF) in controlling caries progression in children when compared with active treatments or placebos. A search for randomized clinical trials that evaluate the effectiveness of SDF for caries control in children compared to active treatments or placebos with follow-ups longer than 6 months was performed in PubMed, Scopus, Web of Science, LILACS, BBO, Cochrane Library, and grey literature. The risk of bias tool from the Cochrane Collaboration was used for quality assessment of the studies. The quality of the evidence was evaluated using the GRADE approach. Meta-analysis was performed on studies considered at low risk of bias. A total of 5,980 articles were identified. Eleven remained in the qualitative synthesis. Five studies were at “low,” 2 at “unclear,” and 4 studies at “high” risk of bias in the key domains. The studies from which the information could be extracted were included for meta-analysis. The arrestment of caries at 12 months promoted by SDF was 66% higher (95% CI 41-91%; p < 0.00001) than by other active material, but it was 154% higher (95% CI 67-85%; p < 0.00001) than by placebos. Overall, the caries arrestment was 89% higher (95% CI 49-138%; p < 0.00001) than using active materials/placebo. No heterogeneity was detected. The evidence was graded as high quality. The use of SDF is 89% more effective in controlling/arresting caries than other treatments or placebos. The quality of the evidence was graded as high.

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Clinical Trials of Silver Diamine Fluoride in Arresting Caries among Children

Cited by 214 publications

References 20 publications

Evidence-Based Dentistry Update on Silver Diamine Fluoride

Evidence-Based Dentistry Update on Silver Diamine Fluoride

Effect of silver diamine fluoride and potassium iodide on shear bond strength of glass ionomer cements to caries-affected dentine

Silver Diamine Fluoride Has Efficacy in Controlling Caries Progression in Primary Teeth: A Systematic Review and Meta-Analysis

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