Comparison of the effects of curcuminoid from Curcuma domestica Val. rhizome extract and diclofenac sodium on the liver function of patients with osteoarthritis

Abstract

Osteoarthritis is the most frequent joint disease worldwide. Patients with osteoarthritis mostly use nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac sodium for reducing pain. Diclofenac sodium frequently disturbs the liver function. Curcuminoid has an anti-inflammatory activity and some references state that curcuminoid protects the liver function. The purpose of this study was to compare the effects of curcuminoid from Curcuma domestica Val. rhizome extract and diclofenac sodium on the liver function of patients with osteoarthritis. A total of 80 patients with knee osteoarthritis were enrolled. Subjects were divided randomly into two groups; a group received 30 mg of curcuminoid from C. domestica Val. 3 times daily (curcuminoid group) and the other received 25 mg of diclofenac sodium 3 times daily (diclofenac group). Assessment of results includes serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) performed before and after 4 weeks of treatment. In the curcuminoid group, there was no significant decrease of AST serum level (p < 0.15) and ALT serum level (p < 0.41), whereas in the diclofenac group, there was no significant increase of AST serum level (p=0.05) and significant increase of ALT serum level (p<0.01). The increase of serum AST and ALT level in the diclofenac group were significantly different as compared to the decrease of the levels in the curcuminoid group. This means that diclofenac sodium disturbs liver function, while curcuminoid from C. domestica Val. rhizome extract improves the liver function of patients with osteoarthritis.

Ethnopharmacological study of medicinal plants indigenous knowledge about low back pain therapy in Sumatra, Indonesia

“…The in vivo analgesic efficacy of the alcoholic K. galanga extract was investigated in Wistar rats using the hot plate method and the tail-flick model. According to the findings, the alcohol extract significantly increased the stress tolerance capacity of rats at doses of 1,200 and 600 mg/kg BW for 60 minutes using the hot plate method and 30 minutes via the tail-flick model (Khairullah et al, 2021).…”

Combination of Curcuminoids and Acupressure for Inflammation and Pain in Older People with Osteoarthritis Genu: Protocol for a Randomized Controlled Trial

“…The research’s power (1–β) was also set at 80%, so if the value of β=20%, then the amount of Z1–β=0.842. Previous research [ 18 ] that analyzed changes in leukocytes in participants treated with curcuminoid therapy based on 30 mg turmeric extract taken 3 times a day for 14 days, amounting to 30.00±5.10 mg and meloxicam 1×15 mg per day, obtained a mean Δ value of leukocytes in the control group of 164.1 μL+50.91, and in the treatment group, 174.27 μL+78.93. The total number of participants required in the 2 groups was 60.…”

Pendekatan Etnobotani Tumbuhan Obat Untuk Permasalahan Seksual Suku Tengger Di Desa Argosari, Lumajang, Indonesia

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