Comparison of the Nasal Release of IL-4, IL-10, IL-17, CCL13/MCP-4, and CCL26/eotaxin-3 in Allergic Rhinitis during Season and after Allergen Challenge

Baumann, Ralf; Rabaszowski, Matthaeus; Stenin, Igor; Tilgner, L.; Scheckenbach, Kathrin; Wiltfang, Jens; Schipper, Joerg; Chaker, Adam; Wagenmann, Martin

doi:10.2500/ajra.2013.27.3913

Cited by 53 publications

(48 citation statements)

References 49 publications

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“…44 Early-and late-phase markers, such as tryptase and IL-5 and IL-13, respectively, can aid in our understanding of how various interventions affect the nasal mucosa. 45 Further study of the cell count, particularly eosinophils from nasal lavage samples, offers an insight into the inflammatory cells responsible for the symptoms and the phase they are most active in. 48 Modification of gene expression after immunotherapy or other treatments can be studied using samples collected by nasal brushings or scraping.…”

Section: Interpretation Of Research Study Resultsmentioning

confidence: 99%

“…44 The weights of blown secretions are considered to be representative of the severity of rhinorrhea after NAC. 45 Brooks et al 46 found that antihistamines and systemic corticoids reduced the weight of blown secretions concurrent with decreases in sneezing. The secretion fluid has been used to evaluate cytokines, such as interleukin (IL) 5, IL-16, and soluble ST2 (the decoy receptor of IL-33).…”

Section: Blown Secretionsmentioning

confidence: 97%

“…These cytokines have been found to be increased in allergic participants in season and after the NAC, helping to reveal the comparability of NAC to real life. 45 Drawbacks of blown secretions include the fact that the area of the nose from which the cells and secretions originate is unknown and that they can be difficult to obtain from healthy, nonallergic persons. 44 To overcome this, some researchers have used techniques in which saline is sprayed into the nose before blowing.…”

Section: Blown Secretionsmentioning

confidence: 99%

See 2 more Smart Citations

Nasal allergen challenge studies of allergic rhinitis: a guide for the practicing clinician

Soliman

North

Steacy

et al. 2014

Annals of Allergy, Asthma & Immunology

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Section: Interpretation Of Research Study Resultsmentioning

confidence: 99%

Section: Blown Secretionsmentioning

confidence: 97%

Section: Blown Secretionsmentioning

confidence: 99%

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Nasal allergen challenge studies of allergic rhinitis: a guide for the practicing clinician

Soliman

North

Steacy

et al. 2014

Annals of Allergy, Asthma & Immunology

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“…AR is characterized by chronic inflammation of the nasal mucosa with hypersensitivity, hypersecretion and remodeling, which results from seasonal or perennial responses to specific allergens, such as pollens, dust mites, pets, pests, and molds. The pathological changes of their nasal mucosa are closely related to the massive infiltration and aberrant activation of many immune cells and the abnormal production of various inflammatory mediators (Baumann et al 2013;Scadding 2014;Kamekura et al 2016). Although numerous efforts have been exerted to verify the potential mechanisms following these changes, the treatment of AR is still quite difficult.…”

Section: Introductionmentioning

confidence: 99%

Identification and Functional Profiling of Differentially Expressed Long Non-Coding RNAs in Nasal Mucosa with Allergic Rhinitis

Teng

Liu

et al. 2017

Tohoku J. Exp. Med.

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Long non-coding RNAs (lncRNAs) have been proved to play important roles in a variety of human immune diseases. However, their pathological effects on the development of allergic rhinitis (AR) have not been clearly understood. The aim of this study was to determine the expression profile of lncRNAs in nasal mucosa of AR patients by lncRNA microarray and to predict potential roles of specific lncRNAs in the pathogenic mechanisms of AR by analysis of lncRNA-mRNA co-expression network, Gene Ontology (GO) and pathway. The lncRNA microarray analysis showed that a total of 2,259 lncRNAs (1,033 up-regulated and 1,226 down-regulated) and 704 mRNAs (157 up-regulated and 547 down-regulated) were significantly differentially expressed in the nasal mucosa samples from 4 AR patients as compared to those from 4 non-allergic subjects (fold change > 2; P < 0.05). In addition, the lncRNA-mRNA co-expression network contained 143 network nodes including 76 lncRNAs and 67 mRNAs, in which 117 significant correlation pairs presented as positive, and 108 pairs presented as negative. The results from GO and pathway analysis indicated that the lncRNAs-coexpressed mRNAs were enriched in several biological processes and cellular signaling pathways related to AR development, such as positive regulation of interleukin-13 secretion, Fc epsilon RI signaling pathway and NF-kappa B signaling pathway. To summary, our study provides important information on the molecular mechanisms and biological functions of these AR-related lncRNAs, which could be utilized for developing novel therapeutic strategies for AR.

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“…15 More recently, Baumann et al found a significant increase of IL-17A in the nasal lavages of patients with seasonal AR after nasal allergen challenge. 20 On the other hand, Groger et al showed that elevated levels of IL-17A in nasal secretions were found in patients with nonallergic rhinitis with eosinophilia syndrome (NARES) compared with healthy controls as well as AR. 17 Mouse models have shown that IL-17A contributes to the development and regulation of AR.…”

mentioning

confidence: 99%

Local Expression of Interleukin-17a is Correlated with Nasal Eosinophilia and Clinical Severity in Allergic Rhinitis

Makihara

Okano

Fujiwara

et al. 2014

Allergy�Rhinol (Providence)

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Interleukin (IL)-17A is a major cytokine produced by Th17 cells, which are associated with chronic inflammations. The local expression of IL-17A in allergic rhinitis (AR) remains to be characterized. We sought to determine the role of IL-17A expression in human inferior turbinate mucosa in the pathophysiology of AR. Inferior turbinate mucosa was sampled from medical treatment–resistant, surgery-required patients with perennial AR (PAR, n = 21), nonallergic rhinitis with eosinophilia syndrome (NARES, n = 7), and nonallergic hypertrophic rhinitis (HR, n = 13). IL-17A expression was determined with immunohistochemical staining. The mean number of IL-17A+ cells and eosinophils per field were counted. Total serum immunoglobulin E (IgE) levels, blood eosinophil count, and forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio were also examined in each patient. IL-17A was primarily expressed in infiltrating inflammatory cells. The number of IL-17A+ cells in nasal mucosa was significantly higher in the PAR group compared with HR (p = 0.002) and NARES (p = 0.021) groups. There was a significant and positive correlation between the number of IL-17A+ cells and total nasal symptom score (rho = 0.403; p = 0.011), especially sneezing score (rho = 0.471; p = 0.003). The number of IL-17A+ cells was significantly and positively correlated with the degree of eosinophil infiltration (rho = 0.623; p < 0.001), but not with total serum IgE levels (rho = 0.284; p = 0.098), blood eosinophil counts (rho = 0.302; p = 0.056), or FEV1/FVC ratio (rho = 0.092; p = 0.569). The present study provides evidence that IL-17A expression in the nasal mucosa is associated with the pathophysiology of AR, including disease severity and nasal eosinophilia.

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Comparison of the Nasal Release of IL-4, IL-10, IL-17, CCL13/MCP-4, and CCL26/eotaxin-3 in Allergic Rhinitis during Season and after Allergen Challenge

Abstract: Nasal IL-17, MCP-4, and, possibly, eotaxin-3 may aggravate and IL-10 may alleviate nasal mucosal allergy.

Cited by 53 publications

References 49 publications

Nasal allergen challenge studies of allergic rhinitis: a guide for the practicing clinician

Nasal allergen challenge studies of allergic rhinitis: a guide for the practicing clinician

Identification and Functional Profiling of Differentially Expressed Long Non-Coding RNAs in Nasal Mucosa with Allergic Rhinitis

Local Expression of Interleukin-17a is Correlated with Nasal Eosinophilia and Clinical Severity in Allergic Rhinitis

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