Controlled release of gentamicin from calcium phosphate/alginate bone cement

Chen, Chan-Hen David; Chen, Chuncheng; Shie, Ming‐You; Huang, Chiao-Hui; Ding, Shinn-Jyh

doi:10.1016/j.msec.2010.10.002

Cited by 38 publications

(8 citation statements)

References 31 publications

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“…Particularly, natural polymers exhibit high biocompatibility and low tissue damage [30,32]. Among available natural, biocompatible polymers, alginates are widely used in tissue engineering [33 -39] and drug delivery [37,[39][40][41], because of their ability to form hydrogels when multivalent cations react with their guluronic residues [40,42]. As cross-linked alginate gels degrade, cross-linking ions are released due to the exchange with monovalent cations from the media [42].…”

Section: Introductionmentioning

confidence: 99%

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Cattalini

Hoppe

Pishbin

et al. 2015

J. R. Soc. Interface.

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This work aimed to develop novel composite biomaterials for bone tissue engineering (BTE) made of bioactive glass nanoparticles (Nbg) and alginate cross-linked with Cu 2þ or Ca 2þ (AlgNbgCu, AlgNbgCa, respectively). Twodimensional scaffolds were prepared and the nanocomposite biomaterials were characterized in terms of morphology, mechanical strength, bioactivity, biodegradability, swelling capacity, release profile of the cross-linking cations and angiogenic properties. It was found that both Cu 2þ and Ca 2þ are released in a controlled and sustained manner with no burst release observed. Finally, in vitro results indicated that the bioactive ions released from both nanocomposite biomaterials were able to stimulate the differentiation of rat bone marrow-derived mesenchymal stem cells towards the osteogenic lineage. In addition, the typical endothelial cell property of forming tubes in Matrigel was observed for human umbilical vein endothelial cells when in contact with the novel biomaterials, particularly AlgNbgCu, which indicates their angiogenic properties. Hence, novel nanocomposite biomaterials made of Nbg and alginate cross-linked with Cu 2þ or Ca 2þ were developed with potential applications for preparation of multifunctional scaffolds for BTE.

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Section: Introductionmentioning

confidence: 99%

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Cattalini

Hoppe

Pishbin

et al. 2015

J. R. Soc. Interface.

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“…A CPC composite modified by the addition of 0.5% of alginate was tested as a drug carrier for gentamicin by Chen et al [ 64 ]. The release profiles of unmodified and modified cements were compared.…”

Section: Matrix Additivementioning

confidence: 99%

Factors influencing the drug release from calcium phosphate cements

Fosca

Rau

Uskoković³

2022

Bioactive Materials

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Thanks to their biocompatibility, biodegradability, injectability and self-setting properties, calcium phosphate cements (CPCs) have been the most economical and effective biomaterials of choice for use as bone void fillers. They have also been extensively used as drug delivery carriers owing to their ability to provide for a steady release of various organic molecules aiding the regeneration of defective bone, including primarily antibiotics and growth factors. This review provides a systematic compilation of studies that reported on the controlled release of drugs from CPCs in the last 25 years. The chemical, compositional and microstructural characteristics of these systems through which the control of the release rates and mechanisms could be achieved have been discussed. In doing so, the effects of (i) the chemistry of the matrix, (ii) porosity, (iii) additives, (iv) drug types, (v) drug concentrations, (vi) drug loading methods and (vii) release media have been distinguished and discussed individually. Kinetic specificities of in vivo release of drugs from CPCs have been reviewed, too. Understanding the kinetic and mechanistic correlations between the CPC properties and the drug release is a prerequisite for the design of bone void fillers with drug release profiles precisely tailored to the application area and the clinical picture. The goal of this review has been to shed light on these fundamental correlations.

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“…Although the combined use of CPC and drug-impregnated mMBG can control drug release, improve biocompatibility, promote bone growth, and address the limitations of their respective applications, it also affects the physicochemistry, microstructure, injectability, hardening properties, and mechanical strength [ 17 , 18 ]. Although MBG/CPC bone cements have been studied before, the exact composition can vary due to the different properties of CPC bone cements, and the drug loading can be considered as different [ 16 , 17 , 18 , 19 ]. Therefore, the purpose of this study was to prepare different ratios of gentamicin-impregnated mMBG and composite them into CPCs to develop an mMBG/CPC bone cement.…”

Section: Introductionmentioning

confidence: 99%

Injectability, Processability, Drug Loading, and Antibacterial Activity of Gentamicin-Impregnated Mesoporous Bioactive Glass Composite Calcium Phosphate Bone Cement In Vitro

Chu

Huang

et al. 2022

Biomimetics

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Calcium phosphate cement (CPC) is similar to bone in composition and has plasticity, while mesoporous bioactive glass (MBG) has the advantage of releasing Si, which can promote osteogenic properties and drug loading capacity. A sol–gel-prepared MBG micro-powder (mMBG) and further impregnated antibiotic gentamicin sulfate (Genta@mMBG: 2, 3, and 4 mg/mL) antibiotic were added to CPC at different weight ratios (5, 10, and 15 wt.%) to study CPC’s potential clinical applications. Different ratios of mMBG/CPC composite bone cement showed good injectability and disintegration resistance, but with increasing mMBG addition, the working/setting time and compressive strength decreased. The maximum additive amount was 10 wt.% mMBG due to the working time of ~ 5 min, the setting time of ~ 10 min, and the compressive strength of ~51 MPa, indicating that it was more suitable for clinical surgical applications than the other groups. The 2Genta@mMBG group loaded with 2 mg/mL gentamicin had good antibacterial activity, and the 10 wt.% 2Genta@mMBG/CPC composite bone cement still had good antibacterial activity but reduced the initial release of Genta. 2Genta@mMBG was found to have slight cytotoxicity, so 2Genta@mMBG was composited into CPC to improve the biocompatibility and to endow CPC with more advantages for clinical application.

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Controlled release of gentamicin from calcium phosphate/alginate bone cement

Cited by 38 publications

References 31 publications

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Factors influencing the drug release from calcium phosphate cements

Injectability, Processability, Drug Loading, and Antibacterial Activity of Gentamicin-Impregnated Mesoporous Bioactive Glass Composite Calcium Phosphate Bone Cement In Vitro

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