Cytotoxic Effects of Bangladeshi Medicinal Plant Extracts

Abstract

To investigate the cytotoxic effect of some Bangladeshi medicinal plant extracts, 16 Bangladeshi medicinal plants were successively extracted with n-hexane, dichloromethane, methanol and water. The methanolic and aqueous extracts were screened for cytotoxic activity against healthy mouse fibroblasts (NIH3T3) and three human cancer-cell lines (gastric: AGS; colon: HT-29; and breast: MDA-MB-435S) using the MTT assay. Two methanolic extracts (Hygrophila auriculata and Hibiscus tiliaceous) and one aqueous extract (Limnophila indica) showed no toxicity against healthy mouse fibroblasts, but selective cytotoxicity against breast cancer cells (IC50 1.1–1.6 mg mL−1). Seven methanolic extracts from L. indica, Clerodendron inerme, Cynometra ramiflora, Xylocarpus moluccensis, Argemone mexicana, Ammannia baccifera and Acrostichum aureum and four aqueous extracts from Hygrophila auriculata, Bruguiera gymnorrhiza, X. moluccensis and Aegiceras corniculatum showed low toxicity (IC50 > 2.5 mg mL−1) against mouse fibroblasts but selective cytotoxicity (IC50 0.2–2.3 mg mL−1) against different cancer cell lines. The methanolic extract of Blumea lacera showed the highest cytotoxicity (IC50 0.01–0.08 mg mL−1) against all tested cell lines among all extracts tested in this study. For some of the plants their traditional use as anticancer treatments correlates with the cytotoxic results, whereas for others so far unknown cytotoxic activities were identified.

Cytotoxicity of Trichoderma spp. Cultural Filtrate Against Human Cervical and Breast Cancer Cell Lines

“…(Uddin et al, 2009). Several recent studies have investigated the cytotoxicity of natural plant extracts against human cervical and breast cancer cell lines (MCF-7 and HeLa) (Hamedeyazdan et al, 2012;Zhao et al, 2014).…”

Antiproliferative Activity of Marrubium persicum Extract in the MCF-7 Human Breast Cancer Cell Line

“…Owing to the fact that anticancer activity of plants has been verified to be connected with a variety of phytochemicals, such as polyphenols, flavonoids and catechins (Uddin et al, 2009), many researchers had also confirmed higher phenolic content of plant materials increases the antioxidant activity of the plant since there is a linear correlation between phenolic contents and antioxidant activity (Rietjens et al, 2005;Ravikumar et al, 2008;Rahman et al, 2011). Although plant phenolics are good source of antioxidants, they differ in their abilities to quench various free radicals, so as verifying the exact role of these phytochemicals in certain kind of an oxidative stress related diseases is of substantial importance.…”

In-vitro Antiviral Activity of a Novel Phthalic Acid Ester Derivative Isolated from the Bangladeshi Mangrove Fern Acrostichum aureum

“…The cytotoxicity of CPHP and CAP were tested against monkey kidney cells using the MTT assay according to the method described previously [20]. The IC 50 values were calculated with probit analysis software [21].…”