Development of lycopene-loaded lipid-core nanocapsules: physicochemical characterization and stability study

Santos, Priscilla Pereira dos; Paese, Karina; Guterres, Sílvia Stanisçuaski; Pohlmann, Adriana Raffin; Costa, Tania Hass; Jablonski, André; Flôres, Simone Hickmann; Rios, Alessandro de Oliveira

doi:10.1007/s11051-015-2917-5

Cited by 58 publications

(35 citation statements)

References 40 publications

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“…Similar values were found by Santos et al (2015), that obtained lycopene entrapped in lipid-core nanocapsules with the PCL as wall material, the mean diameter (D 4,3 ) of these nanocapsules was 153 nm with a span value of 1.32. Contri et al (2013) researched alternatives (Brazil nut, sunflower seed, olive, rose hip, grape seed, and carrot oils) to replace the oil core of the Eudragit RS100® nanocapsules often made with capric/caprylic triglycerides and observed that the nanocapsules made with alternative oils presented a higher size (280 nm) and span value (2.50) than those made with capric/caprylic triglycerides.…”

Section: Particle Diameter and Zeta Potentialsupporting

confidence: 89%

“…During the cold storage, the pH values of the formulations of the BALNs and BNs declined from 3.17 ± 0.03 to 2.95 ± 0.05 at day 100 (BALNs) and from 5.50 ± 0.12 to 4.25 ± 0.20 at day 100 (BNs). Santos et al (2015) conducted a study with the same technique of the present work for the production of the nanocapsules, they worked with lycopeneloaded lipid-core nanocapsules (85 μg/mL) stored at 25°C and also found a reduction in pH values from 6.01 ± 0.04 to 5.60 ± 0.02 during the storage (28 days).…”

Section: Phmentioning

confidence: 91%

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The Production, Characterization, and the Stability of Carotenoids Loaded in Lipid-Core Nanocapsules

Silva

Nora

Cantillano

et al. 2016

Food Bioprocess Technol

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The use of carotenoids in foods is limited due to their poor solubility in water-rich matrices, and the nanoencapsulation emerges as an alternative to allowing the solubilization and to protect the carotenoids against degradation. The aims of this study were to produce, by the interfacial deposition of the preformed polymer, to characterize, and evaluate the stability of nanocapsules obtained from a blend of β-carotene, α-carotene, and lutein (BALNs) and nanocapsules of synthetic β-carotene (BNs). The encapsulation efficiency, transmission electron microscopy, and the logarithm of the distribution of the coefficient of the BALNs and BNs, with 26 μg/mL of carotenoids, were performed after preparation. During 100 days of storage (4°C) for the BALNs and BNs, the carotenoids retention, hydrogen potential, color, particle diameter, and the zeta potential were analyzed. The z-average and zeta potential after 100 days of storage for the BALNs and BNs were, respectively, 166.53 ± 4.71 nm/−18.37 ± 2.06 mV and 190.90 ± 7.87 nm/−9.08 ± 1.23 mV. At the end of storage, the β-carotene content was 67.62 ± 7.77 % (BALNs) and 11.69 ± 1.65 % (BNs). The βcarotene retention in the BALNs was higher than in the BNs probably due to the synergism that occurs among the compounds. Regardless of the decrease in the pH values and the b* coordinate, the formulations of the BALNs and BNs were considered physically stable during the storage. Nevertheless, beyond the physical stability, the BALNs presented a satisfactory carotenoid retention at end of storage.

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Section: Particle Diameter and Zeta Potentialsupporting

confidence: 89%

Section: Phmentioning

confidence: 91%

The Production, Characterization, and the Stability of Carotenoids Loaded in Lipid-Core Nanocapsules

Silva

Nora

Cantillano

et al. 2016

Food Bioprocess Technol

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“…The nanoencapsulation provide more stability of these pigments in the presence of oxygen, heat, and light, which, in general, improves the stability, solubility, and bioavailability of encapsulated species and promotes its controlled release. [26][27][28] The nanoencapsulation of β-carotene presents an alternative for greater use of carotenoid, the encapsulation of this pigment using poly-ɛ-caprolactone (PCL) with oil nucleus, and presents high encapsulation efficiency, able to provide greater retention and stability when subjected to thermal treatments or light presence. 26,29 In this context, β-carotene may represent an excellent natural compound for addition in biodegradable films and the nanoencapsulation may be a promising technique to increase the solubility and stability of this carotenoid, which to date have not been evaluated for addition in films under nanometer scale.…”

mentioning

confidence: 99%

Synthesis of biodegradable films based on cassava starch containing free and nanoencapsulated β‐carotene

et al. 2018

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β-Carotene may represent an excellent natural antioxidant, and nanoscale encapsulation may contribute to development of a new technique for addition of antioxidants in active packaging.The objective of this work was to develop active biodegradable films with addition of free β-carotene or β-carotene-loaded lipid-core nanocapsules and to evaluate the interaction with the polymeric matrix. The addition of free β-carotene led to a decrease in the mechanical properties of films, result of their hydrophobic character and less interaction with the matrix.β-Carotene nanocapsules caused the increase of colour intensity of films, elongation at rupture, and less light transmission, with the gradual increase according to increase in concentration. Films with β-carotene nanocapsules presented greater protection of sunflower oil, with lower formation of oxidation products. The lower stability of free antioxidant led to behavior similar to control film, with less oxidation protection. The addition of nanocapsules can provide better interaction with the structure, since the encapsulated carotenoid exhibits solubility in aqueous medium and present better distribution, without altering the rapid biodegradability and thermal stability of films. The results show that encapsulated bioactive compounds can be used as hydrophobic natural antioxidants and added in active biodegradable packages for maintaining food safety and extending the shelf life.

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“…The higher acidity may be associated with ionization of the functional groups present on the polymer chains of PCL, for example, the terminal carboxylic groups, which are present in the polymer, lowering the pH. 14,37,39 The PCL-nanoparticles presented negative zeta potentials, ranging from −19.7 to −33.8 mV (UNSP80 and NCP80, respectively). The negative charge is due to the PCL polymer and surfactant Lipoid S45 ® .…”

Section: Technological Evaluation Of Quinine-loaded Nanocapsulesmentioning

confidence: 99%

“…42 These lipids are ionized at pH 7.0 to induce a negative surface charge on nanoparticles, which contributes to their stability. 43 The PCL polymer also influences the negative zeta potential of nanoparticles due to the presence of ester groups and the polymer, based on the values previously described for formulations prepared with this polymer 34,39,44,45 and the influence of P80-coating, through the particle by steric stabilization. 46,47 In this study, PCL-NS presented a zeta potential less than that of PCL-NC, suggesting that capric/caprylic triglycerides also influence the zeta potential, since the organization of these nanostructures differs.…”

Section: Technological Evaluation Of Quinine-loaded Nanocapsulesmentioning

confidence: 99%

<p>Effects of Surface Characteristics of Polymeric Nanocapsules on the Pharmacokinetics and Efficacy of Antimalarial Quinine</p>

Michels¹,

Maciel²,

Nakama³

et al. 2019

IJN

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Introduction: The surface charge of nanoparticles, such as nanospheres (NS) and nanocapsules (NC), has been studied with the purpose of improving the in vivo performance of drugs. The aim of this study was to develop, characterize, and evaluate the in vitro antimalarial efficacy of NCP80 and NSP80 (polysorbate coated) or NCEUD and NSEUD (prepared with Eudragit RS 100) loading quinine (QN). Methods: Formulations were prepared by the nanoprecipitation method, followed by wide physicochemical characterization. Antimalarial activity in Plasmodium berghei-infected mice and populational pharmacokinetics (PopPK) in rats were evaluated. Results: The formulations showed a nanometric range (between 138 ± 3.8 to 201 ± 23.0 nm), zeta potential (mV) of −33.1 ± 0.7 (NCP80), −30.5 ± 1 (UNCP80), −25.5 ± 1 (NSP80), −20 ± 0.3 (UNSP80), 4.61 ± 1 (NCEUD), 14.1 ± 0.9 (UNCEUD), 2.86 ± 0.3 (NSEUD) and 2.84 ± 0.6 (UNSEUD), content close to 100%, and good QN protection against UVA light. There was a twofold increase in the penetration of QN into infected erythrocytes with NC compared to that with NS. There was a significant increase in t 1/2 for all NC evaluated compared to that of Free-QN, due to changes in Vdss. PopPK analysis showed that NCP80 acted as a covariate to Q (intercompartmental clearance) and V2 (volume of distribution in the peripheral compartment). For NCEUD, V1 and Q were modified after QN nanoencapsulation. Regarding in vivo efficacy, NCEUD increased the survival of mice unlike Free-QN. Conclusion: Cationic nanocapsules modified the pharmacology of QN, presenting a potential alternative for malaria treatment.

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Development of lycopene-loaded lipid-core nanocapsules: physicochemical characterization and stability study

Cited by 58 publications

References 40 publications

The Production, Characterization, and the Stability of Carotenoids Loaded in Lipid-Core Nanocapsules

The Production, Characterization, and the Stability of Carotenoids Loaded in Lipid-Core Nanocapsules

Synthesis of biodegradable films based on cassava starch containing free and nanoencapsulated β‐carotene

<p>Effects of Surface Characteristics of Polymeric Nanocapsules on the Pharmacokinetics and Efficacy of Antimalarial Quinine</p>

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