2015
DOI: 10.1162/jocn_a_00770
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Disentangling the Role of Cortico-Basal Ganglia Loops in Top–Down and Bottom–Up Visual Attention: An Investigation of Attention Deficits in Parkinson Disease

Abstract: Abstract■ It is solidly established that top-down (goal-driven) and bottom-up (stimulus-driven) attention mechanisms depend on distributed cortical networks, including prefrontal and frontoparietal regions. On the other hand, it is less clear whether the BG also contribute to one or the other of these mechanisms, or to both. The current study was principally undertaken to clarify this issue. Parkinson disease (PD), a neurodegenerative disorder primarily affecting the BG, has proven to be an effective model for… Show more

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Cited by 29 publications
(29 citation statements)
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References 156 publications
(193 reference statements)
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“…S1 and S2a-f). Our results are consistent with other fMRI studies demonstrating decreased activation/connectivity within frontoparietal attention and executive control networks in amnestic AD-MCI as compared to HC (Neufang et al, 2011;Rombouts et al, 2002;Saykin et al, 2004;Sorg et al, 2007), and in PD-MCI as compared to PD-NC (Amboni et al, 2015;Baggio et al, 2015;Gratwicke et al, 2015), and with cognitive studies demonstrating impaired top-down control of visual attention in PD (Tommasi et al, 2015) and in AD-MCI (Redel et al, 2012). While impaired attention, working memory capacity and executive function in PD-MCI have been mostly linked to fronto-striatal and mesocortical dopamine network deficits (Gratwicke et al, 2015;Cools et al, 2008), dementia in both AD and PD has been related to cholinergic network dysfunction (Ballinger et al, 2016;Bohnen et al, 2015Bohnen et al, , 2003Francis et al, 1999;Hilker et al, 2005;Perez-Lloret and Barrantes, 2016).…”
Section: Discussionsupporting
confidence: 92%
“…S1 and S2a-f). Our results are consistent with other fMRI studies demonstrating decreased activation/connectivity within frontoparietal attention and executive control networks in amnestic AD-MCI as compared to HC (Neufang et al, 2011;Rombouts et al, 2002;Saykin et al, 2004;Sorg et al, 2007), and in PD-MCI as compared to PD-NC (Amboni et al, 2015;Baggio et al, 2015;Gratwicke et al, 2015), and with cognitive studies demonstrating impaired top-down control of visual attention in PD (Tommasi et al, 2015) and in AD-MCI (Redel et al, 2012). While impaired attention, working memory capacity and executive function in PD-MCI have been mostly linked to fronto-striatal and mesocortical dopamine network deficits (Gratwicke et al, 2015;Cools et al, 2008), dementia in both AD and PD has been related to cholinergic network dysfunction (Ballinger et al, 2016;Bohnen et al, 2015Bohnen et al, , 2003Francis et al, 1999;Hilker et al, 2005;Perez-Lloret and Barrantes, 2016).…”
Section: Discussionsupporting
confidence: 92%
“…Attentional projections from the PFC, via the BG, inhibit the superior colliculus to facilitate initiation of voluntary and inhibit reflexive saccades (Terao et al ., ). Dopamine depletion in the striatum in PD impacts cortico‐BG loops (Deijen et al ., ; Tommasi et al ., ), which may be one reason for the overall reduction in saccade frequency in PD compared to controls.…”
Section: Discussionmentioning
confidence: 97%
“…Decades of research have implicated the basal ganglia in a wide array of cognitive and motor functions, many of which are associated with conscious processing (Schroll and Hamker, 2013). Most notably, deficits observed in disorders such as Parkinson's disease suggest a role of the basal ganglia in voluntary movement initiation (Wurtz and Hikosaka, 1986), sequential action performance (Benecke et al, 1987;Jin et al, 2014), attention (Tommasi et al, 2015;Peters et al, 2016), and working memory (Lewis et al, 2005;Gruber et al, 2006). In many cases, the functionality of primitive sensorimotor reflexes in Parkinson's disease patients is correlated with increases in cognitive impairment, suggesting a decreased ability to exert top-down control over unconscious behavior (Vreeling et al, 1993).…”
Section: Neurocomputational Implementation Of Top-down Gatingmentioning
confidence: 99%