Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity

Kawaguchi, Kosuke; Suzuki, Eiji; Nishie, Mariko; Kii, Isao; Kataoka, Tatsuki R.; Hirata, Masahiro; Inoue, Masashi; Pu, Fengling; Iwaisako, Keiko; Tsuda, Mitsuya; Yamaguchi, Ayane; Haga, Hironori; Hagiwara, Masatoshi; Toi, Masakazu

doi:10.1007/s00262-017-2002-2

Cited by 6 publications

(6 citation statements)

References 31 publications

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“…It was reported that NRP1 is expressed not only on endothelial and cancer cells but also on macrophages, and other cell types present in the tumor microenvironment [10,11,34,35]. Our finding that in oral squamous cell carcinoma the number of infiltrating NRP1+ cells correlated with the number of CD163+ infiltrating cells, suggests that the part of the NRP1+ cells represented M2 macrophages.…”

Section: Discussionsupporting

confidence: 58%

Immunohistochemical study on neuropilin 1 (NRP1) immunoexpression in oral squamous cell carcinoma

Stasikowska-Kanicka

Wągrowska-Danilewicz

Danilewicz

2018

Folia Histochem Cytobiol.

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The present study revealed overexpression of NRP1 in OSCC, especially in OSCC patients with metasta-sis, suggesting that NRP1 could potentially contribute to metastasis of oral cancer. The correlation between the number of NRP1+ infiltrating cells and CD163+ macrophages suggests that NRP1+ infiltrating macrophages are present in tumor microenvironment and may play a role in the progressions of oral cancer.

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Section: Discussionsupporting

confidence: 58%

Immunohistochemical study on neuropilin 1 (NRP1) immunoexpression in oral squamous cell carcinoma

Stasikowska-Kanicka

Wągrowska-Danilewicz

Danilewicz

2018

Folia Histochem Cytobiol.

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“…Global deficiency of Nrp1 in mice is embryonically lethal due to a heart, blood vessel, and neuronal developmental defect (6,7). In the immune system, Nrp1 is expressed primarily on naturally occurring regulatory T (Treg) cells (8), recent thymic immigrants of IL-17-producing invariant NKT cells (9), and some myeloid cells (10,11). Expression of Nrp1 is thought to be able to differentiate between naturally occurring Treg cells and peripherally induced cells (12,13), although there is some controversy in the matter (14).…”

mentioning

confidence: 99%

Neuropilin-1 Expression on CD4 T Cells Is Atherogenic and Facilitates T Cell Migration to the Aorta in Atherosclerosis

Gaddis

Padgett

et al. 2019

The Journal of Immunology

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Neuropilin 1 (Nrp1) is a type I transmembrane protein that plays important roles in axonal guidance, neuronal development, and angiogenesis. Nrp1 also helps migrate thymus-derived regulatory T cells to vascular endothelial growth factor (VEGF)-producing tumors. However, little is known about the role of Nrp1 on CD4 T cells in atherosclerosis. In ApoE 2/2 mice fed a Western diet for 15 wk, we found a 2-fold increase in Nrp1 + Foxp3 2 CD4 T cells in their spleens, periaortic lymph nodes, and aortas, compared with chow-fed mice. Nrp1 + Foxp3 2 CD4 T cells had higher proliferation potential, expressed higher levels of the memory marker CD44, and produced more IFN-g when compared with Nrp1 2 CD4 T cells. Treatment of CD4 T cells with oxLDL increased Nrp1 expression. Furthermore, atherosclerosis-susceptible mice selectively deficient for Nrp1 expression on T cells developed less atherosclerosis than their Nrp1-sufficient counterparts. Mechanistically, we found that CD4 T cells that express Nrp1 have an increased capacity to migrate to the aorta and periaortic lymph nodes compared to Nrp1 2 T cells, suggesting that the expression of Nrp1 facilitates the recruitment of CD4 T cells into the aorta where they can be pathogenic. Thus, we have identified a novel role of Nrp1 on CD4 T cells in atherosclerosis. These results suggest that manipulation of Nrp1 expression on T cells can affect the outcome of atherosclerosis and lower disease incidence.

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“…Initially, macrophages are polarized to the M1 type, and cooperate with other immune cells to eliminate tumor cells. When tumor cells are in low oxygen and low pH, they will release Neuropilin-1 (Nrp-1), TGF-β, IL6, IL4, Tim-3 to promote the transformation of macrophages into M2 type, which can help tumor cells to escape immune and secrete growth factors to enhance tumor growth (27)(28)(29)(30). Interestingly, M2 infiltrated highly in the high CRG_score group and subtype B.…”

Section: Discussionmentioning

confidence: 99%

Identification of cuproptosis related subtypes and construction of prognostic signature in gastric cancer

Dong

Zhao²,

Zhang³

et al. 2023

Front. Surg.

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Cuprotosis is a novel mechanism of cell death that differs from known mechanisms, which depends on mitochondrial respiration and is closely related to lipoylated components of the tricarboxylic acid (TCA) cycle. However, it is unclear whether cuprotosis-related genes (CRGs) affect the tumor microenvironment (TME) and prognosis of patients with gastric cancer. In this study, the genetic and transcriptional characteristics of CRGs in gastric cancer (GC) were analyzed, and five CRGs that were differentially expressed and correlated with the survival of patients were obtained. Two different molecular subtypes were identified according to the five CRGs. Then, we constructed a CRG_score applied to patients of any age, gender, and stage. Subsequently, we found that cluster B and a high CRG_score had a worse prognosis, fewer immune checkpoints, and higher tumor immune dysfunction and exclusion (TIDE) compared to cluster A and a low CRG_score. In addition, two subtypes and the CRG_score were closely associated with clinicopathological characteristics, human leukocyte antigens (HLAs) and TME cell infiltration. A high CRG_score was featured with decreased microsatellite instability-high (MSI-H) and mutational burden. Meanwhile, the CRG_score was significantly related to the cancer stem cell (CSC) index and chemotherapeutic response. Moreover, we developed a nomogram to predict the survival probability of patients. Our study explained the role of CRGs in GC, and the prognostic signature could potentially provide an approach for personalized tumor therapy.

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Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity

Cited by 6 publications

References 31 publications

Immunohistochemical study on neuropilin 1 (NRP1) immunoexpression in oral squamous cell carcinoma

Immunohistochemical study on neuropilin 1 (NRP1) immunoexpression in oral squamous cell carcinoma

Neuropilin-1 Expression on CD4 T Cells Is Atherogenic and Facilitates T Cell Migration to the Aorta in Atherosclerosis

Identification of cuproptosis related subtypes and construction of prognostic signature in gastric cancer

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