Doxorobicin as cargo in a redox-responsive drug delivery system capped with water dispersible ZnS nanoparticles

Žid, Lukáš; Zeleňák, Vladimı́r; Girman, Vladimír; Bednarčı́k, J.; Zeleňáková, A.; Szűcsová, Jaroslava; Hornebecq, Virginie; Hudák, Alexander; Šuleková, Monika; Váhovská, Lucia

doi:10.1039/d0ra02091e

Cited by 10 publications

(8 citation statements)

References 51 publications

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“…The XRD data of 3‐aminophenol‐grafted AGE/ZnS nanoparticles exhibit the zinc blende structure with cubic phase. The crystal planes of (111), (220), and (311) of zinc blende structure were obtained at three broad bands with 2θ values of (28.75), (48.17), and (56.69), respectively [ 1 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…This low release can be due to famotidine molecules adsorbed in the ZnS pores that are not grafted with the polymer. Over time, an equilibrium is created between the famotidine molecules and the adsorbent surface, which indicates that the amount of famotidine in the media is constant [ 1 , 34 ]. Famotidine, with its alkaline properties onto 3‐aminophenol‐grafted AGE/ZnS, is most stable in phosphate buffer solutions, whereas in the simulated gastric environment with harsh acidic medium, famotidine was released more quickly.…”

Section: Resultsmentioning

confidence: 99%

“…Low water solubility causes some drugs to have a lower absorption volume in the gastrointestinal tract. This lower absorption results in higher dosing being needed to maintain an effective concentration in the place of treatment [ 1 ]. Researchers have proposed several methods to dominate the low solubility of drugs in water.…”

Section: Introductionmentioning

confidence: 99%

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Design of 3‐aminophenol‐grafted polymer‐modified zinc sulphide nanoparticles as drug delivery system

Abniki

Azizi

Panahi

2021

IET Nanobiotechnology

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Zinc sulphide (ZnS) nanoparticles were synthesized by the coprecipitation method. The ZnS nanoparticle surface was polymerized with allyl glycidyl ether (AGE), and 3aminophenol was then deposited as a ligand on nanosorbent. The modified nanosorbent was investigated with Fourier transform infrared spectroscopy and thermogravimetric analysis. The particle size of the modified nanosorbent was studied with scanning electron microscopy. Some characteristic factors of the adsorption process such as pH and time were investigated for famotidine using the modified nanosorbent. The equilibrium adsorption study of famotidine by 3-aminophenol-grafted AGE/ZnS was analysed by adsorption isotherms of the Langmuir, Freundlich, and Temkin models. The famotidine-releasing process was investigated in simulated biological fluids (intestinal fluid at pH of 7.4 and gastric fluid at pH of 1.2) and demonstrated 65% and 73% famotidine release during periods of 30 h (pH = 7.4) and 60 min (pH = 1.2), respectively. These results reveal the optimal performance of 3-aminophenol-grafted AGE/ZnS for sustained drug delivery.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Design of 3‐aminophenol‐grafted polymer‐modified zinc sulphide nanoparticles as drug delivery system

Abniki

Azizi

Panahi

2021

IET Nanobiotechnology

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“…Based on this knowledge and great drug delivery potential of MSNs, in our previous works, we have described the different mesoporous silica particles for pH driven drug release 22 , 23 , redox potential driven release 24 , temperature driven drug release 25 or light driven drug release 26 , 27 . In addition to physicochemical-characterisation, we studied biocompatibility and cytotoxicity of the prepared DDS in vitro on the U87 MG and SKBR3 cells using the microscopic techniques, flow-cytometry, MTT assay, apoptosis assay and CAM assay 22 , 23 , 28 , 29 .…”

Section: Introductionmentioning

confidence: 99%

In vivo study of light-driven naproxen release from gated mesoporous silica drug delivery system

Almáši

Matiašová

Šuleková

et al. 2021

Sci Rep

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A drug delivery system based on mesoporous particles MCM-41 was post-synthetically modified by photo-sensitive ligand, methyl-(2E)-3-(4-(triethoxysilyl)-propoxyphenyl)-2-propenoate (CA) and the pores of MCM-41 particles were loaded with Naproxen sodium salt (NAP). The CA was used as a photoactive molecule that can undergo a reversible photo-dimerization by [2π + 2π] cycloaddition when irradiated with UV light of specific wavelengths. Thus, it has a function of gate-keeper that is responsible for opening/closing the pores and minimizing premature release of NAP. The physicochemical properties of the prepared system were studied by infrared spectroscopy (IR), nitrogen adsorption measurements, thermogravimetric analysis (TGA), scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDX). The mechanism of the opening/closing pores was confirmed by UV measurements. In vitro and in vivo drug release experiments and the concentration of released NAP was determined by UV spectroscopy and high-performance liquid chromatography (HPLC). In vivo drug release in the blood circulatory system of rats has demonstrated the effective photo-cleavage reaction of CA molecules after UV-light stimulation. The localization and morphological changes of the particles were studied in the blood and liver of rats at different time intervals. The particles in the blood have been shown to retain their original rod-like shape, and the particles in the liver have been hydrolysed, which has resulted in spherical shape with a reduced size.

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“…In our previous works, we have prepared and described the different mesoporous silica particles that release drugs either on diffusion principle [ 23 ] or using external physical stimulus, e.g., light-driven drug release [ 24 ], redox driven drug release [ 25 ], or pH-driven drug release [ 26 ]. In addition to these stimuli, the magnetic field is another option to be used in vectored drug delivery and/or in delivery with low premature leakage.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Characterization and Moderate Cytotoxicity of Magnetic Mesoporous Silica Nanocomposite for Drug Delivery of Naproxen

et al. 2021

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In this study, we describe the magnetic and structural properties and cytotoxicity of drug delivery composite (DDC) consisting of hexagonally ordered mesoporous silica, iron oxide magnetic nanoparticles (Fe2O3), and the drug naproxen (Napro). The nonsteroidal anti-inflammatory drug (NSAID) naproxen was adsorbed into the pores of MCM-41 silica after the ultra-small superparamagnetic iron oxide nanoparticles (USPIONs) encapsulation. Our results confirm the suppression of the Brownian relaxation process caused by a “gripping effect” since the rotation of the whole particle encapsulated in the porous system of mesoporous silica was disabled. This behavior was observed for the first time, to the best of our knowledge. Therefore, the dominant relaxation mechanism in powder and liquid form is the Néel process when the rotation of the nanoparticle’s magnetic moment is responsible for the relaxation. The in vitro cytotoxicity tests were performed using human glioma U87 MG cells, and the moderate manifestation of cell death, although at high concentrations of studied systems, was observed with fluorescent labeling by AnnexinV/FITC. All our results indicate that the as-prepared MCM-41/Napro/Fe2O3 composite has a potential application as a drug nanocarrier for magnetic-targeted drug delivery.

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Doxorobicin as cargo in a redox-responsive drug delivery system capped with water dispersible ZnS nanoparticles

Abstract: Redox-responsive drug delivery system was studied. ZnS nanoparticles served as pore capping agent to prevent premature release of anticancer drug. Such cargo can be monitored by magnetic field which opens possibilities its use in theranostics.

Cited by 10 publications

References 51 publications

Design of 3‐aminophenol‐grafted polymer‐modified zinc sulphide nanoparticles as drug delivery system

Design of 3‐aminophenol‐grafted polymer‐modified zinc sulphide nanoparticles as drug delivery system

In vivo study of light-driven naproxen release from gated mesoporous silica drug delivery system

Magnetic Characterization and Moderate Cytotoxicity of Magnetic Mesoporous Silica Nanocomposite for Drug Delivery of Naproxen

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