Dynamic coherent focus OCT with depth-independent transversal resolution

Lexer, Franz; Hitzenberger, C. K.; Drexler, Wolfgang; Molebny, S.; Sattmann, Harald; Sticker, Markus; Fercher, Adolf Friedrich

doi:10.1080/095003499149845

Cited by 23 publications

(22 citation statements)

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“…To achieve higher and more uniform lateral resolution without image processing, a higher numerical aperture objective can be used along with dynamic focus tracking throughout the penetration depth. 2 Alternatively, image-processing techniques, such as deconvolution 3,4 and inverse scattering, 5 can be used to improve lateral resolution. Additionally, recently a Gabor-based fusion technique demonstrated 2-μm lateral resolution.…”

Section: Introductionmentioning

confidence: 99%

Design of a handheld optical coherence microscopy endoscope

2011

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Abstract. Optical coherence microscopy (OCM) combines coherence gating, high numerical aperture optics, and a fiber-core pinhole to provide high axial and lateral resolution with relatively large depth of imaging. We present a handheld rigid OCM endoscope designed for small animal surgical imaging, with a 6-mm diam tip, 1-mm scan width, and 1-mm imaging depth. X-Y scanning is performed distally with mirrors mounted to micro galvonometer scanners incorporated into the endoscope handle. The endoscope optical design consists of scanning doublets, an afocal Hopkins relay lens system, a 0.4 numerical aperture water immersion objective, and a cover glass. This endoscope can resolve laterally a 1.4-μm line pair feature and has an axial resolution (full width half maximum) of 5.4 μm. Images taken with this endoscope of fresh ex-vivo mouse ovaries show structural features, such as corpus luteum, primary follicles, growing follicles, and fallopian tubes. This rigid handheld OCM endoscope can be useful for a variety of minimally invasive and surgical imaging applications. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Introductionmentioning

confidence: 99%

Design of a handheld optical coherence microscopy endoscope

2011

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“…This is often needed in testing a variety of low coherence sources such as superluminescent diodes (SLEDs). Mounting a small lens on the stage allows dynamic focusing applications [4][5][6][7] and we show encouraging results in dynamic focusing applied to OCT.…”

Section: Introductionmentioning

confidence: 68%

Evaluation of a cheap ultrasonic stage for light source coherence function measurement, optical coherence tomography and dynamic focusing

Krstajić¹,

Matcher²,

Childs³

et al. 2009

Meas. Sci. Technol.

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We evaluate the performance of a cheap ultrasonic stage in setups related to optical coherence tomography. The stage was used in several configurations: 1) optical delay line in optical coherence tomography (OCT) setup; 2) as a delay line measuring coherence function of a low coherence source (e.g. superluminescent diode); 3) in a dynamic focusing arrangement. The results are as follows: the stage is suitable for coherence function measurement (coherence length up to 70 μm) of the light source and dynamic focusing. We found it unsuitable for OCT due to unstable velocity profile. Despite this, the velocity profile has a repeatable shape (4% over 1000 A-scans) and slight modifications to the stage promise wider applications.

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“…Therefore, adaptive ranging would greatly enhance visualization of many clinically relevant sites. One limitation of this method is its inability to provide a very high lateral resolution in the case where dynamic focusing [22][23][24] cannot be very easily implemented due to limited space reasons. When the dynamic focusing is not possible, a compromise should be made between the lateral resolution and confocal parameter.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Adaptive ranging for optical coherence tomography

Iftimia¹,

Bouma²,

Boer³

et al. 2004

Opt. Express

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At present, optical coherence tomography systems have a limited imaging depth or axial scan range, making diagnosis of large diameter arterial vessels and hollow organs difficult. Adaptive ranging is a feedback technique where image data is utilized to adjust the coherence gate offset and range. In this paper, we demonstrate an adaptive optical coherence tomography system with a 7.0 mm range. By matching the imaging depth to the approximately 1.5 mm penetration depth in tissue, a 3 dB sensitivity improvement over conventional imaging systems with a 3.0 mm imaging depth was realized.

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Dynamic coherent focus OCT with depth-independent transversal resolution

Cited by 23 publications

References 0 publications

Design of a handheld optical coherence microscopy endoscope

Design of a handheld optical coherence microscopy endoscope

Evaluation of a cheap ultrasonic stage for light source coherence function measurement, optical coherence tomography and dynamic focusing

Adaptive ranging for optical coherence tomography

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