Effect of inclusion complexation of meloxicam with β-cyclodextrin- and β-cyclodextrin-based nanosponges on solubility, in vitro release and stability studies

Shende, Pravin; Gaud, Ram; Bakal, Ravindra L.; Patil, Dipmala

doi:10.1016/j.colsurfb.2015.09.002

Cited by 102 publications

(60 citation statements)

References 11 publications

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“…This tool explored the exothermic and endothermic processes at the temperature range from −120 to 600°C [85][86][87][88]. The thermal behavior of the various drugs (dexamethasone, furbiprofen, doxorubicin [80], Itraconazole [59], camptothecin [58], resverarol [55], amino salicylic acid [65], gamma-oryzanol [89], telmisartan [53], curcumin [54], acyclovir [37], quercetin [76] and meloxicam [64]) entrapped in the NS was examined by DSC.…”

Section: Differential Scanning Calorimetrymentioning

confidence: 99%

“…Crystalline and paracrystalline nature of NS and porosity can be revealed using this technique. A number of molecules (acetyl salicylic acid [65], camptothecin [58], telmisartan [53], resveratrol [55], acyclovir [37], quercetin [76], meloxicam [64], curcumin [54], and dexamethasone [82]) encapsulated in nanosponges have been evaluated using this technique.…”

Section: X-ray Diffraction Techniquesmentioning

confidence: 99%

“…The topographic changes (related to the interactions of the polymer, active moiety and cross-linking agent) are provided [98]. Various pharmacological active molecules like resveratrol [55], telmisartan [53], dexamethasone [82], and meloxicam [64] have been explored microscopically using SEM.…”

Section: Microscopic Techniquesmentioning

confidence: 99%

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Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug Delivery

Kumar¹,

Dalal²,

Rao³

2020

Colloid Science in Pharmaceutical Nanotechnology

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Nanotechnology showed great promise and impact on administration of therapeutic agents owing to its advantages over contemporary delivery systems. Nanoscale carriers like nanosponges represent a novel category of hyper crosslinked polymer structures with nanosized cavities which can be filled with variety of active moieties (hydrophilic as well as hydrophobic). These nanocarriers can circulate around the body until they found the specific target site and adhere on the surface and release the active moiety in a predictable and controlled manner, resulting in more effective delivery of a given dosage. Nanosponge technology helps to reduce drug associated side effects, improve stability, increase elegance and improve the flexibility of formulations, administered orally, parenterally and topically. Among nanosponges, cyclodextrin-based nanosponges (CDNS) are smart versatile carriers studied widely for drug delivery applications. Statistically, it have presented that approximately 40% of active moieties marketed currently and about 90% of active moieties in their preliminary phase confront problems regarding to solubility. In the past decade, the number of studies describing CDNS has dramatically increased. In the present chapter, scientists working in arena of nanotechnology can get an idea of fabrication, characterization and therapeutic utilities of nanosponges.

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Section: Differential Scanning Calorimetrymentioning

confidence: 99%

Section: X-ray Diffraction Techniquesmentioning

confidence: 99%

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Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug Delivery

Kumar¹,

Dalal²,

Rao³

2020

Colloid Science in Pharmaceutical Nanotechnology

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“…The drug and formulations (SD, PM, HD, SL and FD) were coated with a thin gold layer by Sputter coater Machine (SPI Sputter, China) and analyzed by SEM (Hitachi, Japan) [8].…”

Section: Semmentioning

confidence: 99%

Effect of Solubility Enhancement Methods, In-Vitro Release and Stability Studies of Indomethacin

Shende

Naik

et al. 2016

JAPLR

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MethodsSolvent dispersion: An equivalent quantity of β-cyclodextrin and ammonia, were heated in a water bath at 100°C. Eventually the indomethacin was added to the complex and kept under AbstractThe objective of present work was to compare the effect of different solubility enhancement methods like solvent dispersion, physical mixture, hydrotropy, solid dispersion and freeze drying on in-vitro release and stability studies of indomethacin. Indomethacin, BCS class II NSAIDs, acts by inhibiting COX-I and II enzymes and uses in treating various conditions like rheumatoid arthritis, pain and headache. Inclusion complex formulations were prepared using different methods like solvent dispersion, physical mixing, hydrotropy, solid dispersion and freeze drying. Particle size and zeta potential observed varied range of values between 479.4±1.12 to 1417±2.37nm and in between -15.3±1.08 to -24.9±1.18mV respectively. The highest solubility was observed in solid dispersion due to highest reduction of particle size. In-vitro drug release study showed controlled indomethacin release pattern in solid dispersion for 24 h as compared to other inclusion complexes. Solid dispersion method emphasizes its importance in enhancing the solubility and bioavailability, controlled release and stability of indomethacin.

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“…Cyclodextrin and its derivatives can form inclusion complexes of compounds that can increase the solubility of the compound, binding of volatile compounds, protect labile compounds, reducing the toxicity of a compound effect and improve the texture (Shende et al, 2015). Characteristics of cyclodextrin is expected to improve morphology and texture of the membrane SPEEK that is expected to increase the density of the membrane structure, and reducing permeation of methanol through the membrane.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Hybrid SPEEK Based Polymer–Cyclodextrin-Silica Inorganic Membrane for Direct Methanol Fuel Cell Application

Kusworo

Hakim

Hadiyanto

2017

IJRED

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Direct methanol fuel cell (DMFC) is one of several types of fuel cells that use proton exchange membrane (PEM) as a liaison between the reaction at the cathode and anode. Polyether-ether ketone (PEEK) is one of the aromatic polymer that can be applied in DMFC because of its characteristics that are resistant to DMFC environment. The polymer is also quite easy in the sulfonation process using concentrated sulfuric acid. However the role of polyether-ether ketone as DMFC membrane material is still lack of advantage due to its low conductivity and therefore the modification is required to increase the value of proton conductivity of the membrane. The purpose of this experiment is to modify the membrane (sPEEK) with the addition of cyclodextrins-silica, additive variation charge of 2%, 6% and 10%, time and temperature were fixed at 4 hours and 65 o C. The results showed the best results of membrane sPEEK was obtained at the addition of polymer-cyclodextrin-silica 10% with the membrane characteristics of ion exchange capacity of 2.19 meq/g polymer, the degree of sulfonation of 81%, methanol permeability of 3.09 x 10 -9 cm 2 / s and water uptake membrane of 64%.

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Effect of inclusion complexation of meloxicam with β-cyclodextrin- and β-cyclodextrin-based nanosponges on solubility, in vitro release and stability studies

Cited by 102 publications

References 11 publications

Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug Delivery

Cyclodextrin Nanosponges: A Promising Approach for Modulating Drug Delivery

Effect of Solubility Enhancement Methods, In-Vitro Release and Stability Studies of Indomethacin

Enhancement of Hybrid SPEEK Based Polymer–Cyclodextrin-Silica Inorganic Membrane for Direct Methanol Fuel Cell Application

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