Effect of Leptin and Oxidative Stress in the Blood of Obese Individuals

Ahmed, Sabah M.; Maher, Firas T.; Naji, Nazar Ahmed

doi:10.4172/2161-1009.1000288

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Studies in obese individuals have shown a correlation between leptin levels and oxidative stress parameters such as nitric oxide (NO), superoxide anion (O 2 − . ), peroxynitrite, MDA , hydroperoxides, protein carbonyl (PC) contents, GSH, and SOD [106][107][108]. Studies in which hyperleptinemia was induced by the administration of exogenous leptin in nonobese animals suggest that leptin increases the level of systemic oxidative stress [109,110].…”

Section: Leptin Signaling Pathways Pomc;pro-opiomelanocortin Socs3; Intracellular Suppressor Of Cytokine Signal 3 Ptp1b; Protein Tyrosinementioning

confidence: 99%

Leptin and Its Role in Oxidative Stress and Apoptosis: An Overview

Gelen¹,

Kükürt²,

Şengül³

et al. 2021

Role of Obesity in Human Health and Disease

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Adipose tissue (AT) in the body plays a very important role in the regulation of energy metabolism. AT regulates energy metabolism by secreting adipokines. Some of the adipokines released are vaspin, resistin, adiponectin, visfatin and omentin, and leptin. In addition to regulating energy metabolism, leptin plays a role in the regulation of many physiological functions of the body such as regulation of blood pressure, inflammation, nutrition, appetite, insulin and glucose metabolism, lipid metabolism, coagulation, and apoptosis. Among all these physiological functions, the relationship between leptin, oxidative stress, and apoptosis has gained great importance recently due to its therapeutic effect in various types of cancer. For this reason, in this study, the release of leptin, its cellular effects and its effect on oxidative stress, and apoptosis are discussed in line with current information.

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Section: Leptin Signaling Pathways Pomc;pro-opiomelanocortin Socs3; Intracellular Suppressor Of Cytokine Signal 3 Ptp1b; Protein Tyrosinementioning

confidence: 99%

Leptin and Its Role in Oxidative Stress and Apoptosis: An Overview

Gelen¹,

Kükürt²,

Şengül³

et al. 2021

Role of Obesity in Human Health and Disease

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تأثير البقدونس على إنقاص الوزن والإنزيمات المضادة للأکسدة في النساء ذات الوزن الزائد والبدينات

اسحق¹,

مهران²

2018

مجلة الاقتصاد المنزلي.جامعة المنوفية

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The aim of this study was to evaluate effect of parsley on weight loss and antioxidant enzymes in overweight and obese women subjects. A number of 150 women subjects were classified as follow: group (1) 30 normal volunteers women with BMI<25 Kg/m 2 was considered as a control group, group (2) 30 overweight women with BMI between 25-30 Kg/m 2 eating one cup/ day parsley in addition their weight reduction diet, group (3) 30 obese women with BMI>30 Kg/m 2 eating one cup/day parsley in addition their weight reduction diet, group (4) 30 overweight women with BMI between 25-30 Kg/m 2 eating only their weight reduction diet, group (5) 30 obese women with BMI>30 Kg/m 2 eating only their weight reduction diet. The weight reduction diet is containing the same types and quantities for all participants in groups 2, 3, 4 and 5 with exchange during the week days along the study period. Age (35-60 years) with no prior history of chronic diseases was selected from outpatient clinics in Assiut University Hospitals after their agreement for the participation in the study. Information on age, weight, height was collected. Antioxidant enzymes including superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPX) and catalase (CAT) were assessed in the groups at the beginning of the study and after 2 months of intervention. The investigation was

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Evaluation of Oxidative Stress and LeptinLevel in Samples of Iraqi Obese Women

Ali

Yenzeel

Al-ansari

2020

eijs

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The aim of this study is to investigate oxidative stress and leptinlevel in obese women. Fifty obese women with BMI value of ≥ 30.0 kg/m2 and thirty healthy women with BMI<24.9 kg/m2 were involved in the study during their attendance at Gastroenterology and Liver Hospital/ Medical city in Baghdad province from October 2018 to February 2019. The age range for all women was 30-50 years. Blood samples were collected from each participant for the evaluation of the levels of leptin hormone, Super Oxide Dismutase (SOD), and Malondialdehyde (MDA). The results of BMI, leptin hormone, MDA and SOD showed highly significant increase (P<0.01) in obese women in comparison with the control group. Results: The results show that BMI value were significantly higher (P<0.01) in obese women (41.90 ± 0.87kg/m2) in comparison with the control (23.58 ± 0.28kg/m2). The level of leptin hormone was significantly higher(P<0.01) in obese women (1444.00 ± 10.67pg/ml) in comparison with the control (932.26 ± 25.92pg/ml). Also, MDA level was significantly higher(P<0.01) in obese women (6.81 ± 0.29mg/dl) in comparison with the control (4.53 ± 0.44) mg/dl. The level of SOD was significantly higher(P<0.01) in obese women (15.67 ± 1.42mg/dl) in comparison with the control group (3.75 ± 0.60mg/dl). Conclusions: Obesity is detected by the level of leptin Hormone; leptin is regarded as a good parameter for monitoring obesity,showing a high increasewith increasing BMI.Theincrease in obesity causes oxidant stress and formation of MDA that is considered as a major risk factor in obesity,where adecrease in antioxidants was also recorded.

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Effect of Leptin and Oxidative Stress in the Blood of Obese Individuals

Cited by 3 publications

References 26 publications

Leptin and Its Role in Oxidative Stress and Apoptosis: An Overview

Leptin and Its Role in Oxidative Stress and Apoptosis: An Overview

تأثير البقدونس على إنقاص الوزن والإنزيمات المضادة للأکسدة في النساء ذات الوزن الزائد والبدينات

Evaluation of Oxidative Stress and LeptinLevel in Samples of Iraqi Obese Women

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