Effect of Maternal Preeclampsia on Hematological Profile of Newborns in Qatar

Bayoumi, Mohammad A A; Ali, Abir A. H.; Hamad, Sara G.; Ali, Alaa; Elmalik, Einas Elzubier; Elkalaf, Mohamed M. I. R.; Moustafa, Bassem A. A.; Shaltout, Deena; Chandra, Prem; Langtree, Lisa J.; Olayiwola, Noimot O

doi:10.1155/2020/7953289

Cited by 15 publications

(8 citation statements)

References 12 publications

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“…However, these authors did not report on the degree of thrombocytopenia, which is considered mild (150,000 to 100,000), moderate (100,000 to 50,000), and severe (< 50,000) according to the platelet count 10,11 . Conversely, Bayoumi et al reported thrombocytopenia degrees: mild in 13% of neonates born to mothers with PIH compared to 2% in the control group 13 . Tsao et al also estimated a 36% incidence of mild thrombocytopenia in neonates with the same condition 9 .…”

Section: Discussionmentioning

confidence: 91%

Hematological disorders in preterm newborns born to mothers with pregnancy-induced hypertension

Arce-López¹,

Iglesias-Leboreiro²,

Bernárdez-Zapata³

et al. 2022

BMHIM

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Background: Pregnancy-induced hypertension (PIH) has been related to impaired fetal growth, possibly by affecting hematopoiesis. This study aimed to analyze the most frequent hematological alterations in preterm infants born to mothers with PIH. Methods: We conducted a cross-sectional study in newborns born to mothers with PIH. We reviewed 130 hemograms of preterm infants: 45 from mothers with PIH, 71 with preeclampsia, and 14 with HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count). Normality, cytosis conditions, or cytopenia values were adjusted for gestational ages. Differences between groups were analyzed with classical and Bayesian statistics (BF01 = null/alternative hypothesis ratio). Results: Anemia was found in only 1.2% of newborns. In the white blood cell count, the most frequent finding was lymphopenia (56.2%) and monocytosis (38.5%) (p = 0.6, FB01 = 249 y p = 0.81, FB01 = 19.9). Thrombocytopenia was found in 12.5% (p = 0.56, FB01 = 67). No significant differences were observed among PIH groups. Conclusions: Hematological alterations of newborns born to mothers with PIH are frequent and do not show a distinct pattern related to the severity of the affection in the mother. We recommend a full hematological evaluation in these preterm neonates.

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Section: Discussionmentioning

confidence: 91%

Hematological disorders in preterm newborns born to mothers with pregnancy-induced hypertension

Arce-López¹,

Iglesias-Leboreiro²,

Bernárdez-Zapata³

et al. 2022

BMHIM

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“…There is intense interest in the search for biochemical indexes that are related to hematological parameters, including the neutrophil-lymphocyte ratio, red cell distribution width, and platelet parameters, which are simple procedures and easily obtainable (17,18). Platelet parameters have been found to exhibit change before the onset of PE, and several researchers have implied that they can be used in the second trimester as useful biochemical markers for the prediction of PE (19,20).…”

Section: Discussionmentioning

confidence: 99%

The clinical value of platelet parameters combined with sFlt-1/PlGF in predicting preeclampsia

Yan¹,

Sun²,

Zheng³

et al. 2021

Ann Palliat Med

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Background: The aim of this study is to evaluate the association between platelet parameters and soluble vascular endothelial growth factor receptor-1 (sFlt-1)/placenta growth factor (PlGF) in preeclampsia (PE) and establish a prediction model by analyzing commonly used biochemical markers.Methods: A nested case-control study involving 270 pregnant women in their second trimester from the Beijing Jishuitan Hospital was conducted. They were divided into PE group and control group. The levels of PlGF, sFlt-1, sFlt-1/PlGF, and platelet parameters were recorded and compared at 20-24 gestational weeks. The correlation between platelet parameters and PlGF, sFlt-1, and sFlt-1/PLGF was then analyzed.A receiver operating characteristic (ROC) curve was used to calculate the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of various biomarkers in predicting PE.Results: In PE group, the levels of mean platelet volume (MPV), platelet distribution width (PDW), sFlt-1, and sFlt-1/PLGF were higher than in the control group, while the levels of platelet count (PC), PC/MPV, and PLGF in PE group were lower. Spearman correlation analysis showed that PC and PC/ MPV were negatively correlated with sFlt-1 and sFlt-1/PLGF, and positively correlated with PLGF, while further analysis found that PC/MPV had the largest area under the ROC curve with sensitivity of 83.7%

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“…Gestational hypertension and preeclampsia may have similar pathophysiological processes 12,13 . The incidence of early-onset thrombocytopenia in neonates born to mothers with preeclampsia is approximately 9.2-36%, which is significantly higher than that in newborns of normotensive mothers 4,9,14,15 . Therefore, we hypothesized that maternal gestational hypertension impacts the incidence of early-onset neonatal thrombocytopenia.…”

Section: Introductionmentioning

confidence: 91%

Effects of Pregnancy-Induced Hypertension on Early-Onset Neonatal Thrombocytopenia

Zhou

et al. 2023

Preprint

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Background Gestational hypertension and preeclampsia are potentially linked to similar pathophysiological processes. Maternal preeclampsia increases the occurrence of early-onset neonatal thrombocytopenia. We hypothesized that maternal gestational hypertension would likewise impact the incidence of early-onset neonatal thrombocytopenia. Therefore, we conducted a retrospective study to validate our hypothesis. Methods In this study, we included 538 neonates, comprising 318 and 220 neonates born to healthy mothers and those with pregnancy-induced hypertension (PIH), respectively. The minimum platelet count within 72 hours of birth was recorded for these neonates. The incidence of early-onset thrombocytopenia in neonates in relation to maternal gestational hypertension, preeclampsia, and health status was evaluated. The differences between the three groups were analyzed using the chi-square test. Logistic regression analysis was conducted to assess the relationship between maternal gestational hypertension or preeclampsia and the risk of early-onset neonatal thrombocytopenia. Results The incidence of early-onset thrombocytopenia in neonates born to mothers with preeclampsia was significantly higher than in those born to mothers with gestational hypertension or healthy mothers. Significant differences were observed between the three groups (30.0% vs. 13.3% vs. 7.9%, P < 0.001). Maternal gestational hypertension (OR=2.55, 95% CI 1.10–5.91, P < 0.05) and preeclampsia (OR=2.41, 95% CI 1.18–4.93, P <0.05) increased the risk of early-onset neonatal thrombocytopenia when compared to healthy mothers. Conclusions Our findings suggest that maternal gestational hypertension increases the occurrence of early-onset neonatal thrombocytopenia. Therefore, we recommend conducting platelet count screening in the early stages for newborns of mothers with gestational hypertension.

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Effect of Maternal Preeclampsia on Hematological Profile of Newborns in Qatar

Cited by 15 publications

References 12 publications

Hematological disorders in preterm newborns born to mothers with pregnancy-induced hypertension

Hematological disorders in preterm newborns born to mothers with pregnancy-induced hypertension

The clinical value of platelet parameters combined with sFlt-1/PlGF in predicting preeclampsia

Effects of Pregnancy-Induced Hypertension on Early-Onset Neonatal Thrombocytopenia

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