Effect of Water Extract Of Tetrapleura Tetraptera (Aidon) On Haematological And Biochemical Parameters in Rats infected With Trypanosoma Brucei

Okochi, VI; Gbenie, GO; Kazeem, A A; Af, Fagbenro-Beyioku; Igbodudu, HE; Arukwe, U.

doi:10.4314/nqjhm.v9i1.12345

Cited by 6 publications

(5 citation statements)

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“…The reduction in RBC, Hb and PCV and the increase in WBC of infected mice was more observed in the curative than suppressive tests. This is consistent with work of Okochi et al (1999) who reported increase in WBC and decrease in RBC, Hb and PCV in rats infected with Trypanosama bracei.…”

Section: Discussionsupporting

confidence: 93%

In vivo antimalarial activity of the ethanolic leaf extract of Hyptis suaveolens poit on Plasmodium berghei in Mice

Dawet¹,

Anyanwu²,

Dede³

et al. 2012

Int. J. Bio. Chem. Sci

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The ethanolic leaf extract of Hyptis suaveolens was evaluated for antimalarial activity against Plasmodium berghei in infected mice. In the 4 day suppressive test, 60 male and female albino mice (weight: 18-23 g) were infected and treatment began immediately (Day 0), while administration started 72 hours post infection in the curative test. For each test, mice were divided into 5 groups of 12 animals; each group was administered one of the following: 10 mg/kg, 25 mg/kg and 50 mg/kg of the crude extract, 5 mg/kg of chloroquine phosphate or 0.2 ml normal saline for four consecutive days. Thin blood smears were prepared and examined microscopically under x 100 objective on day 4 to day 7 and the percentage parasitaemia were recorded. On day 7 the red blood cells (RBC), white blood cells (WBC), haemoglobin (Hb) and packed cell volume (PCV) were evaluated. The extract demonstrated dose-dependent inhibition effect on the parasites with 42.76% and 18.03% at 50 mg/kg, 33.69% and 10.22% at 25 mg/kg for suppressive and curative tests respectively, while at 10 mg/kg, 22.39% and 6.06% suppression were recorded in the suppressive and curative tests respectively. The RBC, HB and PCV values decreased while there was an increase in WBC compared with that of the control.

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Section: Discussionsupporting

confidence: 93%

In vivo antimalarial activity of the ethanolic leaf extract of Hyptis suaveolens poit on Plasmodium berghei in Mice

Dawet¹,

Anyanwu²,

Dede³

et al. 2012

Int. J. Bio. Chem. Sci

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show abstract

“…The various treatment regimen significantly reduced (p<0.05) Total protein value to 71.0 ± 1. 73., 77.0 ± 3.60, and 71.7±6.33 in the combination groups( CDE) respectively as against 82 ± 4.26 diminazene aceturate group alone, (Okochi et al, 1999). The levels of ALT and AST in the infected and not treated group ( A) was compared significantly different than the tested group( BCEDFG).…”

Section: Discussionmentioning

confidence: 85%

Effects of Allium sativum Bulb Extract,Diminazene Aceturate and Their Combination onParasitaemia, and Biochemical Indices in RatsExperimentally Infected with TrypanosomaBrucei Brucei

Peni¹

2012

J. App. Pharm. Sci.

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Thirty five clinically healthy albino rats of both sexes weighing between 100 -120grams were used to study the effects of Allium sativum bulb extract in combination with diminazene aceturate on parsitemia and biochemical indices in trypanosome brucei brucei infection. The rats were divided in to seven groups (A-G) of five rats each. All the infected rats developed Parasitemia five days post infection. Weakness, increase respiratory rate, rough hair coat Biochemical changes at interval and possible deaths were the major parameters which were carefully observed. All the treatment commenced at the onset of parasitemia by day five post infection. Sub therapeutic dose of Allium sativum at 20mg/kg/bw in combination with 1.7mg/kg/bw of diminazene aceturate (Group C),diminazene aceturate at single standard dose of 3.5mg/kg/bw (Group B) caused a significant reduction (P<0.05) in parasitemia. The liver function enzymes ALT AST level in rats infected and not treated showed significant increase liver function enzymes (Group A) while those treated with standard and sub therapeutic dose (Group BCD) respectively. Had their liver function enzymes towards normal, compare with control (Group G).Its trypanocidal activity was assessed through daily examination of blood parasite, sub therapeutic doses of Allium sativum bulb extracts and its combination appear to be more effective in reducing severity of trypanosome brucei brucei infection and provide alternative in reducing the toxicity of existing trypanocide.

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“…We cannot provide adequate explanations for the biological implications of the reduction in the total protein now until more work is done; however, immune protein constitutes part of the total blood protein observed in infected animals (10). The other reduced chemical components, ASAT and ALAT, are indicators of tissue damage and their rising values must be checked.…”

Section: Discussionmentioning

confidence: 98%

Effects of Aqueous Bulb Extract ofAllium sativum(Garlic) on Hematological and Biochemical Parameters in Rabbits: ExperimentalTrypanosoma bruceissp.bruceiInfection

Mikail

2009

Journal of Herbs, Spices & Medicinal Plants

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Effect of Water Extract Of Tetrapleura Tetraptera (Aidon) On Haematological And Biochemical Parameters in Rats infected With Trypanosoma Brucei

Cited by 6 publications

References 0 publications

<em>In vivo</em> antimalarial activity of the ethanolic leaf extract of <em>Hyptis suaveolens</em> poit on <em>Plasmodium berghei</em> in Mice

<em>In vivo</em> antimalarial activity of the ethanolic leaf extract of <em>Hyptis suaveolens</em> poit on <em>Plasmodium berghei</em> in Mice

Effects of Allium sativum Bulb Extract,Diminazene Aceturate and Their Combination onParasitaemia, and Biochemical Indices in RatsExperimentally Infected with TrypanosomaBrucei Brucei

Effects of Aqueous Bulb Extract ofAllium sativum(Garlic) on Hematological and Biochemical Parameters in Rabbits: ExperimentalTrypanosoma bruceissp.bruceiInfection

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