Effects of Ginkgo biloba on experimental rapid maxillary expansion model: a histomorphometric study

Effects of curcumin and melatonin on bone formation in orthopedically expanded suture in rats: A biochemical, histological and immunohistochemical study

“…CUR can inhibit RANKL‐induced osteoclastogenesis through the suppression of ROS generation . These results are in agreement with other studies that found that bone formation was increased by antioxidants …”

“…Excessive accumulation of reactive oxygen species (ROS) causes oxidative stress and elicits bone resorption with a direct contribution to bone degradation by osteoclast‐generated superoxide. Additionally, osteoblasts produce antioxidants, including GSH‐Px, to protect against ROS . Antioxidant enzymes such as CAT and GSH‐Px play an important role in scavenging ROS produced under oxidative stress .…”

“…Currently, the effects of various substances have been investigated on new bone formation with the aim of improving the stability of RME . Antioxidant‐related studies are carried out by researchers to investigate the effects of antioxidants on bone metabolism via inhibition of osteoclastic activity and promotion of osteoblastic activity …”

Does Shilajit Have an Effect on New Bone Remodelling in the Rapid Maxillary Expansion Treatment? A Biochemical, Histopathological and Immunohistochemical Study

“…These results are in agreement with another researchs that used antioxidants and found that increase in bone formation (1,14,15,25). In contrast to previous studies (14,15), there was no significant difference for the inflammatory cell infiltration between the groups in our study. This difference in results may be clarified by the fact that the shilajit could be responsible for preventing the nuclear factor (NF)-kappaB, an osteblastic differentiation marker elicited by ROS, thereby, the reduction of the inflammation.…”

Effects of low-level laser therapy on osteoblastic bone formation and relapse in an experimental rapid maxillary expansion model

“…Rapid maxillary expansion (RME) and surgically assisted RME are used to expand the transverse dimensions of the palate and maxillary dental arch. These options are widely used well-established techniques in orthodontics and maxillofacial surgery, [1] and are similar to distraction osteogenesis, a surgical process employed to reconstruct skeletal deformities and lengthen or expand bones. [2] For successful treatment, induction of new bone formation within the expanded area, reduction of the currently observed relapse rate of 20-25%, and stabilization of expanded tissue, are required.…”