Effects of single and repeated administrations of
Toki-Shakuyaku-San on the concentrations of brain neurotransmitters
in mice

Itoh, Tadanobu; Murai, S.; Saito, Hirotaro; Masuda, Yuichi

doi:10.1358/mf.1998.20.1.485617

Cited by 12 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that single administration of TSS inhibits vertical and horizontal locomotor activities and inhibited the scopolamineinduced increase in locomotor activities (24). Moreover, single administration of TSS also produces different neurochemical effects such as stimulation of the function of the dopaminergic system and inhibition of that of the adrenergic nervous system (25). In this study, single administration of TSS improved the scopolamine-induced memory disturbance.…”

Section: Discussionsupporting

confidence: 53%

“…The mechanism underlying the memory-enhancing effect of TSS is displayed on cholinergic neurons either indirectly without induction of choline acetyltransferase activity (28) or directly by increasing acetyl choline synthesis (29) and release (our unpublished data) and inhibiting scopolamine-induced decrease in acetylcholine levels (24). However, the memory improving effect of TSS could also involve mechanisms other than enhancement of the cholinergic activity because TSS stimulates the dopaminergic function in the hippocampus (25) and olfactory bulbs (1); it increases concentrations of g-aminobutyric acid (GABA), alanine, and glycine in the cortex, hippocampus, and striatum of senescence accelerated mice (30); and dopaminergic and noradrenergic agents have also been reported to improve the scopolamine-induced memory impairment (20).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Determination of the Effectiveness of Components of the Herbal Medicine Toki-Shakuyaku-San and Fractions of Angelica acutiloba in Improving the Scopolamine-Induced Impairment of Rat’s Spatial Cognition in Eight-Armed Radial Maze Test

et al. 2004

View full text Add to dashboard Cite

Abstract. The improving effects of various components of Toki-Shakuyaku-San (TSS) and fractions isolated from Angelica acutiloba Radix (Toki) on scopolamine-induced spatial memory impairment were investigated in eight-armed radial maze. The scopolamine-induced memory impairment was characterized by prominent increase of error choices in addition to decreased correct choices. Toki, Cnidium officinale Rhizoma (Senkyu), Poria cocos Hoelen (Bukuryo), Alisma orientale Rhizoma (Takusha), and Atractylodes lancea Rhizoma (Sojutsu) increased the correct choices, while only the Toki, Sojutsu, and Takusha decreased the error choices. No effect was produced by Paeonia lactiflora Radix (Shakuyaku). Investigation of effects of fractions isolated from Toki revealed that its activity mainly resided in the butanol layer and its contents of N-methyl-b-carboline-3-carboxamide and amines. Moreover, the alkaloid, internal and external solutions (containing poly-, di-, and monosaccharides) obtained by dialysis with Visking cellophane tubing also improved the memory. However, no improving properties were detected for methanol and hexanol layers, L-(-)-tryptophan, L-arginine, L-(-)-lysine, and choline chloride. The results showed that the TSS components could improve the reference and working memory impaired by scopolamine. The improving effect of TSS is produced greatly by the Toki component, the activity of which was greatly produced by the fraction extracted by butanol.

show abstract

Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Determination of the Effectiveness of Components of the Herbal Medicine Toki-Shakuyaku-San and Fractions of Angelica acutiloba in Improving the Scopolamine-Induced Impairment of Rat’s Spatial Cognition in Eight-Armed Radial Maze Test

et al. 2004

View full text Add to dashboard Cite

show abstract

“…In basic research, the beneficial effects of TSS on learning memory have been recognized in senescence-accelerated resistant mice (SAM) and ovariectomized mice (17,18). TSS also can increase the content and metabolisms of DA and of 5-HT (19).…”

Section: Discussionmentioning

confidence: 99%

Long Term Effects of Toki-shakuyaku-san on Brain Dopamine and Nerve Growth Factor in Olfactory-Bulb-Lesioned Mice

Song

Toriizuka

Jin

et al. 2001

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

ABSTRACT-We used olfactory-bulb-lesioned mice induced by intranasal irrigation with zinc sulfate as a model of dementia, to investigate the effects of Toki-shakuyaku-san (TSS) on monoamines and nerve growth factor (NGF) in brain regions. TSS was given daily through the drinking water for either 1, 2, 3, 4 or 8 weeks from the day after olfactory lesion. The administration of TSS significantly suppressed the decrease of 3,4-dihydroxyphenyl acetic acid (DOPAC) and homovanillic acid (HVA) in olfactory bulb of olfactory-lesioned mice at 1 week, and tended to suppress the decrease of DOPAC and HVA during the experimental session.

show abstract

“…Recent studies showed that many traditional Chinese medicine (TCM) prescriptions with "nourishing" in TCM theory system exerted cognitive enhancement effect after long-term oral administration (Nishiyama et al, 1994;Itoh et al, 1998;Lin et al, 2003;Zhou, 2004). Liuwei Dihuang decoction (LW) is a typical TCM prescription and consists of six herbs including Rehmannia glutinosa Libosch.…”

Section: Introductionmentioning

confidence: 99%

Effects of Liuwei Dihuang decoction on ion channels and synaptic transmission in cultured hippocampal neuron of rat

Yang¹,

Zhou²,

Zhang³

et al. 2006

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Effects of single and repeated administrations of Toki-Shakuyaku-San on the concentrations of brain neurotransmitters in mice

Cited by 12 publications

References 0 publications

Determination of the Effectiveness of Components of the Herbal Medicine Toki-Shakuyaku-San and Fractions of Angelica acutiloba in Improving the Scopolamine-Induced Impairment of Rat’s Spatial Cognition in Eight-Armed Radial Maze Test

Determination of the Effectiveness of Components of the Herbal Medicine Toki-Shakuyaku-San and Fractions of Angelica acutiloba in Improving the Scopolamine-Induced Impairment of Rat’s Spatial Cognition in Eight-Armed Radial Maze Test

Long Term Effects of Toki-shakuyaku-san on Brain Dopamine and Nerve Growth Factor in Olfactory-Bulb-Lesioned Mice

Effects of Liuwei Dihuang decoction on ion channels and synaptic transmission in cultured hippocampal neuron of rat

Contact Info

Product

Resources

About